Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity. (Q34463222)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25035419%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

title

Phosphorodiamidate morpholino oligomers suppress mutant huntingtin expression and attenuate neurotoxicity (English)

1 reference

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9 March 2020

1 reference

2

1 reference

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9 March 2020

Zachary Cordner

3

1 reference

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9 March 2020

author name string

Xin Sun

1

1 reference

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9 March 2020

Jennifer L Pruitt

4

1 reference

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9 March 2020

Manik Bhat

5

1 reference

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9 March 2020

Pan P Li

6

1 reference

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9 March 2020

Geetha Kannan

7

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9 March 2020

Ellen E Ladenheim

8

1 reference

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9 March 2020

Timothy H Moran

9

1 reference

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9 March 2020

Russell L Margolis

10

1 reference

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9 March 2020

Dobrila D Rudnicki

11

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9 March 2020

publication date

4 July 2014

1 reference

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9 March 2020

published in

Human Molecular Genetics

1 reference

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9 March 2020

volume

23

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9 March 2020

issue

23

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9 March 2020

page(s)

6302-6317

1 reference

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describes a project that uses

9 March 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4222366/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

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Six-month partial suppression of Huntingtin is well tolerated in the adult rhesus striatum

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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CAG-encoded polyglutamine length polymorphism in the human genome

6 July 2018

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Morpholino, siRNA, and S-DNA compared: impact of structure and mechanism of action on off-target effects and sequence specificity

6 July 2018

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Trinucleotide Repeat Disorders

6 July 2018

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6 July 2018

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6 July 2018

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Predictive testing for Huntington disease: interpretation and significance of intermediate alleles.

6 July 2018

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6 July 2018

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Polyglutamine neurodegenerative diseases and regulation of transcription: assembling the puzzle

6 July 2018

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Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8.

6 July 2018

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6 July 2018

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RNA pathogenesis of the myotonic dystrophies

6 July 2018

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Expanded CUG repeats trigger aberrant splicing of ClC-1 chloride channel pre-mRNA and hyperexcitability of skeletal muscle in myotonic dystrophy

6 July 2018

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Neurological abnormalities in a knock-in mouse model of Huntington's disease

6 July 2018

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6 July 2018

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A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.

6 July 2018

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Polyglutamine expansion as a pathological epitope in Huntington's disease and four dominant cerebellar ataxias

6 July 2018

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Factor analysis of behavioural symptoms in Huntington's disease.

6 July 2018

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Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.

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21 January 2018

Hunting down huntingtin

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Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein

21 January 2018

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A majority of Huntington's disease patients may be treatable by individualized allele-specific RNA interference.

21 January 2018

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Identification and allele-specific silencing of the mutant huntingtin allele in Huntington's disease patient-derived fibroblasts.

21 January 2018

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Huntington's disease--like 2 is associated with CUG repeat-containing RNA foci

21 January 2018

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Efficacy of systemic morpholino exon-skipping in Duchenne dystrophy dogs

21 January 2018

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Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology

21 January 2018

1 reference

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The Hdh(Q150/Q150) knock-in mouse model of HD and the R6/2 exon 1 model develop comparable and widespread molecular phenotypes

21 January 2018

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The preparation of primary cortical neuron cultures and a practical application using immunofluorescent cytochemistry

21 January 2018

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Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4222366

ACMG/ASHG statement. Laboratory guidelines for Huntington disease genetic testing. The American College of Medical Genetics/American Society of Human Genetics Huntington Disease Genetic Testing Working Group

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25035419

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Exon-skipping events in candidates for clinical trials of morpholino

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25035419

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/HMG/DDU349

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25035419%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25035419%20AND%20SRC:MED&resulttype=core&format=json

9 March 2020

PubMed publication ID

25035419

1 reference