Role of the Keap1/Nrf2 pathway in neurodegenerative diseases (Q34464138)

2 August 2017

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title

Role of the Keap1/Nrf2 pathway in neurodegenerative diseases (English)

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2 August 2017

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Hiromi Yamazaki

1

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2 August 2017

Kunikazu Tanji

2

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2 August 2017

Koichi Wakabayashi

3

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2 August 2017

Shin Matsuura

4

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2 August 2017

Ken Itoh

5

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2 August 2017

publication date

23 February 2015

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2 August 2017

published in

Pathology International

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2 August 2017

volume

65

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2 August 2017

issue

5

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2 August 2017

page(s)

210-219

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Discovery of the negative regulator of Nrf2, Keap1: a historical overview

2 August 2017

cites work

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Toward clinical application of the Keap1-Nrf2 pathway

21 January 2018

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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements

21 January 2018

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Embryonic lethality and fetal liver apoptosis in mice lacking all three small Maf proteins

21 January 2018

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Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

21 January 2018

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Cellular stress responses, the hormesis paradigm, and vitagenes: novel targets for therapeutic intervention in neurodegenerative disorders

21 January 2018

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NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development

21 January 2018

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Preferential expression of antioxidant response element mediated gene expression in astrocytes

21 January 2018

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Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

21 January 2018

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Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription

21 January 2018

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Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis

21 January 2018

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Astrocyte-specific overexpression of Nrf2 delays motor pathology and synuclein aggregation throughout the CNS in the alpha-synuclein mutant (A53T) mouse model

21 January 2018

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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway.

21 January 2018

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Neurodegenerative diseases and oxidative stress

21 January 2018

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Neuronal activity regulates astrocytic Nrf2 signaling

21 January 2018

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Oxidative stress in neurodegeneration: cause or consequence?

21 January 2018

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Mechanisms underlying inflammation in neurodegeneration

21 January 2018

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Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages

21 January 2018

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Electrophilic chemicals but not UV irradiation or reactive oxygen species activate Nrf2 in keratinocytes in vitro and in vivo.

21 January 2018

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Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning.

21 January 2018

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The antioxidant defense system Keap1-Nrf2 comprises a multiple sensing mechanism for responding to a wide range of chemical compounds

21 January 2018

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Nuclear factor erythroid 2-related factor 2 protects against beta amyloid.

21 January 2018

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Phosphatidylinositol 3-kinase, not extracellular signal-regulated kinase, regulates activation of the antioxidant-responsive element in IMR-32 human neuroblastoma cells

21 January 2018

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Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl: PI3K and Nrf2-derived induction of antioxidative proteins

21 January 2018

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Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

21 January 2018

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Nrf2 enhances cholangiocyte expansion in Pten-deficient livers

21 January 2018

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Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway

21 January 2018

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Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2

21 January 2018

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Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling

21 January 2018

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p62 at the crossroads of autophagy, apoptosis, and cancer

21 January 2018

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Listeria monocytogenes ActA-mediated escape from autophagic recognition

21 January 2018

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Aggrephagy: selective disposal of protein aggregates by macroautophagy.

21 January 2018

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Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation

21 January 2018

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Dynamics of the degradation of ubiquitinated proteins by proteasomes and autophagy: association with sequestosome 1/p62.

21 January 2018

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Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration.

21 January 2018

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A genomic screen for activators of the antioxidant response element

21 January 2018

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Role of Nrf2 and p62/ZIP in the neurite outgrowth by carnosic acid in PC12h cells

21 January 2018

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Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy

21 January 2018

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Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy

21 January 2018

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Keap1 is localized in neuronal and glial cytoplasmic inclusions in various neurodegenerative diseases

21 January 2018

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Phosphorylation of serine 349 of p62 in Alzheimer's disease brain

21 January 2018

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Alzheimer's disease--a panorama glimpse

21 January 2018

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Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation

21 January 2018

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Expression of Nrf2 in neurodegenerative diseases

21 January 2018

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NAD(P)H:quinone oxidoreductase activity is increased in hippocampal pyramidal neurons of patients with Aalzheimer's disease.

21 January 2018

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Regional NAD(P)H:quinone oxidoreductase activity in Alzheimer's disease

21 January 2018

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Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment

21 January 2018

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Stabilization of transcription factor Nrf2 by tBHQ prevents oxidative stress-induced amyloid beta formation in NT2N neurons

21 January 2018

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Chitosan prevents oxidative stress-induced amyloid beta formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-kappaB.

21 January 2018

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Kavalactones protect neural cells against amyloid beta peptide-induced neurotoxicity via extracellular signal-regulated kinase 1/2-dependent nuclear factor erythroid 2-related factor 2 activation

21 January 2018

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Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology

21 January 2018

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Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease

21 January 2018

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Nrf2 reduces levels of phosphorylated tau protein by inducing autophagy adaptor protein NDP52.

21 January 2018

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Mechanistic basis of phenothiazine-driven inhibition of Tau aggregation

21 January 2018

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Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation

21 January 2018

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Methylene blue upregulates Nrf2/ARE genes and prevents tau-related neurotoxicity

21 January 2018

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Nerve growth factor and Alzheimer's disease: new facts for an old hypothesis

21 January 2018

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Nrf2 regulates NGF mRNA induction by carnosic acid in T98G glioblastoma cells and normal human astrocytes

21 January 2018

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21 January 2018

Regulation by mitophagy

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Role of oxidative stress in Parkinson's disease

21 January 2018

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α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

21 January 2018

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Expression of NAD(P)H:quinone oxidoreductase in the normal and Parkinsonian substantia nigra

21 January 2018

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Different susceptibility to the Parkinson's toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1

21 January 2018

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Activation of the antioxidant response element in primary cortical neuronal cultures derived from transgenic reporter mice

21 January 2018

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Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro

21 January 2018

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Nrf2-mediated protection against 6-hydroxydopamine

21 January 2018

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Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease.

21 January 2018

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21 January 2018

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In vivo modulation of the Parkinsonian phenotype by Nrf2.

21 January 2018

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Keap1/Nrf2 system regulates neuronal survival as revealed through study of keap1 gene-knockout mice

21 January 2018

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Efficacy of fumaric acid esters in the R6/2 and YAC128 models of Huntington's disease

21 January 2018

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21 January 2018

Identifiers

DOI

10.1111/PIN.12261

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2 August 2017

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