Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation (Q35898639)

11 August 2017

Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation (English)

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11 August 2017

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reactive oxygen species

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Shane E Kruse

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11 August 2017

16

Christian Haass

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Ulrich Brandt

object named as

Ulrich Brandt

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Ilka Wittig

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object named as

Ilka Wittig

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11 August 2017

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Andreas S Reichert

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Marina Jendrach

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11 August 2017

Kristina Leuner

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Tanja Schütt

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11 August 2017

Christopher Kurz

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Schamim H Eckert

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11 August 2017

Carola Schiller

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11 August 2017

Angelo Occhipinti

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Sören Mai

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Gunter P Eckert

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Richard D Palmiter

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Stephan Dröse

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Michael Willem

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Walter E Müller

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28 February 2012

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Antioxidants & Redox Signaling

11 August 2017

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1421-1433

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describes a project that uses

11 August 2017

ImageJ

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3329950/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

cites work

Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model

1 reference

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Mitochondrial dysfunction: common final pathway in brain aging and Alzheimer's disease--therapeutic aspects

27 July 2018

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Amyloid-beta and mitochondria in aging and Alzheimer's disease: implications for synaptic damage and cognitive decline

27 July 2018

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Neural mechanisms of ageing and cognitive decline

27 July 2018

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Oxidative stress, mitochondrial bioenergetics, and cardiolipin in aging

27 July 2018

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27 July 2018

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Abnormal mitochondrial dynamics and neurodegenerative diseases

27 July 2018

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Mitochondrial accumulation of APP and Abeta: significance for Alzheimer disease pathogenesis

27 July 2018

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Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

27 July 2018

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Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

27 July 2018

1 reference

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Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease

27 July 2018

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The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha

27 July 2018

1 reference

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Mitochondria in neuroplasticity and neurological disorders

27 July 2018

1 reference

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Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

27 July 2018

1 reference

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Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy

27 July 2018

1 reference

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Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329950

Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease

27 July 2018

1 reference

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Mitochondrial bioenergetics and structural network organization

27 July 2018

1 reference

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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

27 July 2018

1 reference

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Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

27 July 2018

1 reference

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Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders

27 July 2018

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Mitochondrial regulation of neuronal plasticity

27 July 2018

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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction.

27 July 2018

1 reference

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Ageing and neuronal vulnerability

27 July 2018

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High-resolution respirometry--a modern tool in aging research

27 July 2018

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Mitochondrial metabolism of reactive oxygen species.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329950

Beta-site APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stress-activated protein kinases pathways.

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329950

Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis

27 July 2018

1 reference

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Pathways towards and away from Alzheimer's disease

27 July 2018

1 reference

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Gene regulation and DNA damage in the ageing human brain

27 July 2018

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Protein measurement with the Folin phenol reagent

27 July 2018

1 reference

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Cleavage of amyloid-beta precursor protein and amyloid-beta precursor-like protein by BACE 1

27 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329950

Mitochondria in Alzheimer's disease

27 July 2018

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Complex I-mediated reactive oxygen species generation: modulation by cytochrome c and NAD(P)+ oxidation-reduction state.

27 July 2018

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BACE1 is the major beta-secretase for generation of Abeta peptides by neurons

27 July 2018

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Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation

27 July 2018

1 reference

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Apoptosis and Alzheimer's disease

27 July 2018

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Mitochondrial dysfunction in the senescence accelerated mouse (SAM).

27 July 2018

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Alzheimer-type pathology in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS).

27 July 2018

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Calcium, free radicals, and excitotoxic neuronal death in primary cell culture

27 July 2018

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Mitochondrial dementia: a sporadic case of progressive cognitive and behavioral decline with hearing loss due to the rare m.3291T>C MELAS mutation.

27 July 2018

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Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?

24 September 2018

1 reference

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Amyloid-beta and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

24 September 2018

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Mitochondrial disorders, cognitive impairment and dementia

24 September 2018

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Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329950

Mitochondrial complex I inhibition is not required for dopaminergic neuron death induced by rotenone, MPP+, or paraquat.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329950

Mitochondrial dysfunction in rat brain with aging Involvement of complex I, reactive oxygen species and cardiolipin

24 September 2018

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Mitochondrial dysfunction: an early event in Alzheimer pathology accumulates with age in AD transgenic mice

24 September 2018

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Amyloid precursor protein and mitochondrial dysfunction in Alzheimer's disease

24 September 2018

1 reference

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Mitochondrial and cytosolic thiol redox state are not detectably altered in isolated human NADH:ubiquinone oxidoreductase deficiency.

24 September 2018

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Brain mitochondrial dysfunction in aging: conditions that improve survival, neurological performance and mitochondrial function.

24 September 2018

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Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice

24 September 2018

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Time-course of mitochondrial gene expressions in mice brains: implications for mitochondrial dysfunction, oxidative damage, and cytochrome c in aging

24 September 2018

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Increased beta-Secretase activity in cerebrospinal fluid of Alzheimer's disease subjects.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329950

Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment

24 September 2018

1 reference

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Elevated beta-secretase expression and enzymatic activity detected in sporadic Alzheimer disease

24 September 2018

1 reference

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Beta-secretase protein and activity are increased in the neocortex in Alzheimer disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329950

Increased expression of the amyloid precursor beta-secretase in Alzheimer's disease

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329950

Elevated vulnerability to oxidative stress-induced cell death and activation of caspase-3 by the Swedish amyloid precursor protein mutation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3329950

Morpho-dynamic changes of mitochondria during ageing of human endothelial cells

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22229260

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Short- and long-term alterations of mitochondrial morphology, dynamics and mtDNA after transient oxidative stress

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22229260

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1089/ARS.2011.4173

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

22229260

1 reference