Pregnane X receptor-mediated induction of Cyp3a by black cohosh (Q34482267)

2 August 2017

Pregnane X receptor-mediated induction of Cyp3a by black cohosh (English)

1 reference

2 August 2017

Xiaoyan Pang

1

1 reference

2 August 2017

Jie Cheng

2

1 reference

2 August 2017

Kristopher W Krausz

3

1 reference

2 August 2017

De-an Guo

4

1 reference

2 August 2017

Frank J Gonzalez

5

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2 August 2017

language of work or name

English

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publication date

27 October 2010

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2 August 2017

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2 August 2017

41

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2 August 2017

2

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2 August 2017

112-123

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Fukinolic acid derivatives and triterpene glycosides from black cohosh inhibit CYP isozymes, but are not cytotoxic to Hep-G2 cells in vitro

2 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Black cohosh and suspected hepatotoxicity: inconsistencies, confounding variables, and prospective use of a diagnostic causality algorithm. A critical review

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Efficacy of black cohosh-containing preparations on menopausal symptoms: a meta-analysis

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Clinically based evidence of drug-herb interactions: a systematic review

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Bile acid-activated receptors in the treatment of dyslipidemia and related disorders

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Rifampicin-activated human pregnane X receptor and CYP3A4 induction enhance acetaminophen-induced toxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Black cohosh hepatotoxicity: quantitative causality evaluation in nine suspected cases

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Quantitative determination of triterpenoids and formononetin in rhizomes of black cohosh (Actaea racemosa) and dietary supplements by using UPLC-UV/ELS detection and identification by UPLC-MS.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Sexually dimorphic regulation and induction of P450s by the constitutive androstane receptor (CAR).

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Identification of Ginkgo biloba as a novel activator of pregnane X receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Induction of hepatic glutathione S-transferases in male mice by prototypes of various classes of microsomal enzyme inducers

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

CYP3A4 and pregnane X receptor humanized mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Hepatic effects of Cimicifuga racemosa extract in vivo and in vitro

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Gender-specific induction of cytochrome P450s in nonylphenol-treated FVB/NJ mice

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Herbal product-drug interactions mediated by induction

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Assessing the clinical significance of botanical supplementation on human cytochrome P450 3A activity: comparison of a milk thistle and black cohosh product to rifampin and clarithromycin

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Predicting in vivo drug interactions from in vitro drug discovery data

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Structure and function of the human nuclear xenobiotic receptor PXR.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Black cohosh: just another phytoestrogen?

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

In vivo effects of goldenseal, kava kava, black cohosh, and valerian on human cytochrome P450 1A2, 2D6, 2E1, and 3A4/5 phenotypes

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Black cohosh acts as a mixed competitive ligand and partial agonist of the serotonin receptor.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

PXR, CAR and drug metabolism

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Cross-reactivity of thirteen monoclonal antibodies with ten vaccinia cDNA expressed rat, mouse and human cytochrome P450s

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

Pharmacokinetics and bioavailability of midazolam in man

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

CAR/PXR provide directives for Cyp3a41 gene regulation differently from Cyp3a11.

6 July 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.527021

Autoimmune hepatitis associated with the use of black cohosh: a case study.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.527021

Induction of drug metabolism by forskolin: the role of the pregnane X receptor and the protein kinase a signal transduction pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.527021

Enhanced acetaminophen toxicity by activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.527021

The PREgnane X receptor gene-humanized mouse: a model for investigating drug-drug interactions mediated by cytochromes P450 3A.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.527021

Effects of Cimicifuga racemosa extract on liver morphology and hepatic function indices.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.527021

A novel female-specific member of the CYP3A gene subfamily in the mouse liver.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.527021

Sex-dependent regulation of hepatic cytochrome P-450 by DDT.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.527021

CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.527021

Estrogen-dependent regulation of the expression of hepatic Cyp2b and 3a isoforms: assessment using aromatase-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F00498254.2010.527021

Rifaximin is a gut-specific human pregnane X receptor activator.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3019262

CYP2C11 and CYP2B1 are major cytochrome P450 forms involved in styrene oxidation in liver and lung microsomes from untreated rats, respectively

27 October 2018

1 reference

12 December 2020

Liver failure associated with the use of black cohosh for menopausal symptoms

1 reference

12 December 2020

The pregnane X receptor: from bench to bedside

1 reference

12 December 2020

Stability evaluation of selected polyphenols and triterpene glycosides in black cohosh

1 reference

12 December 2020

Liver failure associated with the use of black cohosh for menopausal symptoms

1 reference

12 December 2020

10.3109/00498254.2010.527021

Identifiers

DOI

1 reference

2 August 2017

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2 August 2017

1 reference