Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism (Q35756705)

10 August 2017

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title

Orphan nuclear receptor-mediated xenobiotic regulation in drug metabolism (English)

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10 August 2017

Wen Xie

1

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10 August 2017

Hirdesh Uppal

2

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10 August 2017

Simrat P S Saini

3

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10 August 2017

Ying Mu

4

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10 August 2017

Joanna M Little

5

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10 August 2017

Anna Radominska-Pandya

6

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10 August 2017

Michael A Zemaitis

7

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10 August 2017

1 May 2004

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10 August 2017

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10 August 2017

9

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10 August 2017

10

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10 August 2017

442-449

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Cytochromes P450, drugs, and diseases

10 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Impact of drug transporter studies on drug discovery and development

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The RXR heterodimers and orphan receptors

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Specific and overlapping functions of the nuclear hormone receptors CAR and PXR in xenobiotic response

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Transcriptional control of intestinal cytochrome P-4503A by 1alpha,25-dihydroxy vitamin D3.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Vitamin D receptor as an intestinal bile acid sensor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Expression of CYP3A4, CYP2B6, and CYP2C9 is regulated by the vitamin D receptor pathway in primary human hepatocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Hepatocyte-specific mutation establishes retinoid X receptor alpha as a heterodimeric integrator of multiple physiological processes in the liver.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Pruritus and cholestasis: therapeutic options

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https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Vitamin K2 regulation of bone homeostasis is mediated by the steroid and xenobiotic receptor SXR.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Bile acid metabolism and the pathophysiology of cholestasis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Protective role of hydroxysteroid sulfotransferase in lithocholic acid-induced liver toxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Redundant pathways for negative feedback regulation of bile acid production

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

A nuclear receptor-mediated xenobiotic response and its implication in drug metabolism and host protection.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903061-2

7 January 2021

10.1016/S1359-6446(04)03061-2

Identifiers

DOI

1 reference

10 August 2017

1 reference