PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity (Q36551142)

14 August 2017

1 reference

title

PXR and CAR: nuclear receptors which play a pivotal role in drug disposition and chemical toxicity (English)

1 reference

14 August 2017

Lesley A Stanley

1

1 reference

14 August 2017

Brian C Horsburgh

2

1 reference

14 August 2017

Jillian Ross

3

1 reference

14 August 2017

Nico Scheer

4

1 reference

14 August 2017

C Roland Wolf

5

1 reference

14 August 2017

language of work or name

English

0 references

publication date

1 January 2006

1 reference

14 August 2017

Drug Metabolism Reviews

1 reference

14 August 2017

38

1 reference

14 August 2017

515-597

1 reference

14 August 2017

3

1 reference

Expression of the drug transporters MDR1/ABCB1, MRP1/ABCC1, MRP2/ABCC2, BCRP/ABCG2, and PXR in peripheral blood mononuclear cells and their relationship with the expression in intestine and liver

14 August 2017

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The critical role of carboxy-terminal amino acids in ligand-dependent and -independent transactivation of the constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Interleukin 1beta inhibits CAR-induced expression of hepatic genes involved in drug and bilirubin clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Alternatively spliced isoforms of the human constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

PXR and the regulation of apoA1 and HDL-cholesterol in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Ligand-activated pregnane X receptor interferes with HNF-4 signaling by targeting a common coactivator PGC-1alpha. Functional implications in hepatic cholesterol and glucose metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

SXR, a novel steroid and xenobiotic-sensing nuclear receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Tissue distribution and chemical induction of multiple drug resistance genes in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The induction of cytochrome P450 3A5 (CYP3A5) in the human liver and intestine is mediated by the xenobiotic sensors pregnane X receptor (PXR) and constitutively activated receptor (CAR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Molecular mechanisms of polymorphic CYP3A7 expression in adult human liver and intestine

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Constitutive androstane receptor and pregnane X receptor gene expression in human liver: interindividual variability and correlation with CYP2B6 mRNA levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Cardiomyocytes overexpressing TNF-alpha attract migration of embryonic stem cells via activation of p38 and c-Jun amino-terminal kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Induction of Human CYP2C9 by Rifampicin, Hyperforin, and Phenobarbital Is Mediated by the Pregnane X Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The nuclear receptors constitutive androstane receptor and pregnane X receptor cross-talk with hepatic nuclear factor 4alpha to synergistically activate the human CYP2C9 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Characterization of activating signal cointegrator-2 as a novel transcriptional coactivator of the xenobiotic nuclear receptor constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Differential transactivation by two isoforms of the orphan nuclear hormone receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

PXR-dependent induction of human CYP3A4 gene expression by organochlorine pesticides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Cloning of a cDNA coding for P-450 LM3c from rabbit liver microsomes and regulation of its expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Repression of PXR-mediated induction of hepatic CYP3A gene expression by protein kinase C.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Coordinate induction of both cytochrome P4503A and MDR1 by St John's wort in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A structural model of the constitutive androstane receptor defines novel interactions that mediate ligand-independent activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Peptide mimetic HIV protease inhibitors are ligands for the orphan receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Identification of an endogenous ligand that activates pregnane X receptor-mediated sterol clearance

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Gene regulation for the senescence marker protein DHEA-sulfotransferase by the xenobiotic-activated nuclear pregnane X receptor (PXR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Dehydroepiandrosterone sulfotransferase is a target for transcriptional induction by the vitamin D receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A pharmacophore for human pregnane X receptor ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Hepatic expression of multiple acute phase proteins and down-regulation of nuclear receptors after acute endotoxin exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Regulation of CYP2B6 in primary human hepatocytes by prototypical inducers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Regulation of human CYP2C9 by the constitutive androstane receptor: discovery of a new distal binding site

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Androstane metabolites bind to and deactivate the nuclear receptor CAR-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Nuclear receptors constitutive androstane receptor and pregnane X receptor activate a drug-responsive enhancer of the murine 5-aminolevulinic acid synthase gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Identification of the novel splicing variants for the hPXR in human livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Human PXR variants and their differential effects on the regulation of human UDP-glucuronosyltransferase gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Nuclear receptor response elements mediate induction of intestinal MDR1 by rifampin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Benzoate X receptors alpha and beta are pharmacologically distinct and do not function as xenobiotic receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Induction profile of rat organic anion transporting polypeptide 2 (oatp2) by prototypical drug-metabolizing enzyme inducers that activate gene expression through ligand-activated transcription factor pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Postnatal expression and induction by pregnenolone-16alpha-carbonitrile of the organic anion-transporting polypeptide 2 in rat liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Enhanced acetaminophen toxicity by activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Induction of rat organic anion transporting polypeptide 2 by pregnenolone-16alpha-carbonitrile is via interaction with pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

CXR, a chicken xenobiotic-sensing orphan nuclear receptor, is related to both mammalian pregnane X receptor (PXR) and constitutive androstane receptor (CAR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

St Johns wort increases expression of P-glycoprotein: implications for drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Mode of action in relevance of rodent liver tumors to human cancer risk.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A novel drug-regulated gene expression system based on the nuclear receptor constitutive androstane receptor (CAR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Effects of triaryl phosphates on mouse and human nuclear receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital-responsive enhancer module of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Induction of bilirubin clearance by the constitutive androstane receptor (CAR)

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Nuclear receptor involvement in the regulation of rat cytochrome P450 3A23 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Amino acids important for ligand specificity of the human constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Role of the hepatocyte nuclear factor 4alpha in control of the pregnane X receptor during fetal liver development

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Characterization of nuclear localization signals and cytoplasmic retention region in the nuclear receptor CAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Phenobarbital-responsive nuclear translocation of the receptor CAR in induction of the CYP2B gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Cytoplasmic Accumulation of the Nuclear Receptor CAR by a Tetratricopeptide Repeat Protein in HepG2 Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Key structural features of ligands for activation of human pregnane X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Biphasic regulation of cytochrome P450 2B1/2 mRNA expression by dexamethasone in primary cultures of adult rat hepatocytes maintained on matrigel

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Use of dominant negative nuclear receptors to study xenobiotic-inducible gene expression in primary cultured hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Functional characterization of four naturally occurring variants of human pregnane X receptor (PXR): one variant causes dramatic loss of both DNA binding activity and the transactivation of the CYP3A4 promoter/enhancer region

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Evolution of the pregnane x receptor: adaptation to cross-species differences in biliary bile salts

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Expression of constitutive androstane receptor splice variants in human tissues and their functional consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

PXR (NR1I2): splice variants in human tissues, including brain, and identification of neurosteroids and nicotine as PXR activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Vitamin E activates gene expression via the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A PXR reporter gene assay in a stable cell culture system: CYP3A4 and CYP2B6 induction by pesticides

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Species comparison in P450 induction: effects of dexamethasone, omeprazole, and rifampin on P450 isoforms 1A and 3A in primary cultured hepatocytes from man, Sprague-Dawley rat, minipig, and beagle dog.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

CYP3A4 induction by drugs: correlation between a pregnane X receptor reporter gene assay and CYP3A4 expression in human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The nuclear receptor CAR is a regulator of thyroid hormone metabolism during caloric restriction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Modulation of mouse and human phenobarbital-responsive enhancer module by nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Dual action of oestrogens on the mouse constitutive androstane receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Activation of the steroid and xenobiotic receptor (human pregnane X receptor) by nontaxane microtubule-stabilizing agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Expression of the pregnane X receptor in mice antagonizes the cholic acid-mediated changes in plasma lipoprotein profile.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The expression of pregnane X receptor and its target gene, cytochrome P450 3A1, in perinatal mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Ligands have various potential effects on the degradation of pregnane X receptor by proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Studies on the mode of action for thyroid gland tumor promotion in rats by phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Regulation of phenobarbital-inducible cytochrome P-450s in rat and mouse liver following dexamethasone administration and hypophysectomy

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Using real-time quantitative TaqMan RT-PCR to evaluate the role of dexamethasone in gene regulation of rat P-glycoproteins mdr1a/1b and cytochrome P450 3A1/2

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Endocrine disruptors induce cytochrome P450 by affecting transcriptional regulation via pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Steroid and xenobiotic receptor (SXR), cytochrome P450 3A4 and multidrug resistance gene 1 in human adult and fetal tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Alternative splicing in the human cytochrome P450IIB6 gene: use of a cryptic exon within intron 3 and splice acceptor site within exon 4

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Alternative splicing in the human cytochrome P450IIB6 gene generates a high level of aberrant messages

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A novel human cytochrome P450 gene (P450IIB): chromosomal localization and evidence for alternative splicing

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Glucocorticoid receptor-interacting protein 1 mediates ligand-independent nuclear translocation and activation of constitutive androstane receptor in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Inhibitory cross-talk between estrogen receptor (ER) and constitutively activated androstane receptor (CAR). CAR inhibits ER-mediated signaling pathway by squelching p160 coactivators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Use of the nuclear receptor PXR to predict drug interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Induction of Cytochrome P450 3A by Paclitaxel in Mice: Pivotal Role of the Nuclear Xenobiotic Receptor, Pregnane X Receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Glucocorticoid and sex hormones as activating or modulating factors for expression of Cyp2b-9 and Cyp2b-10 in the mouse liver and hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Impaired nuclear translocation of CAR in hepatic preneoplastic lesions: association with an attenuated CYP2B induction by phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A reporter gene assay to assess the molecular mechanisms of xenobiotic-dependent induction of the human CYP3A4 gene in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Identification of residues in the PXR ligand binding domain critical for species specific and constitutive activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Transcriptional analysis of the orphan nuclear receptor constitutive androstane receptor (NR1I3) gene promoter: identification of a distal glucocorticoid response element

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Dual effect of dexamethasone on CYP3A4 gene expression in human hepatocytes. Sequential role of glucocorticoid receptor and pregnane X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Identification of the xenosensors regulating human 5-aminolevulinate synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Role of the constitutive androstane receptor in xenobiotic-induced thyroid hormone metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A cell-based reporter gene assay for determining induction of CYP3A4 in a high-volume system

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Regulation of CYP3A4 expression in human hepatocytes by pharmaceuticals and natural products

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Regulation of CYP3A genes in the human respiratory tract

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Induction of CYP3A expression by dehydroepiandrosterone: involvement of the pregnane X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Genetic profiling defines the xenobiotic gene network controlled by the nuclear receptor pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Purification of full-length human pregnane and xenobiotic receptor: polyclonal antibody preparation for immunological characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Alternative splicing within the ligand binding domain of the human constitutive androstane receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Development of a real-time in vivo transcription assay: application reveals pregnane X receptor-mediated induction of CYP3A4 by cancer chemotherapeutic agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

CYP3A induction by liver x receptor ligands in primary cultured rat and mouse hepatocytes is mediated by the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Orphan receptor promiscuity in the induction of cytochromes p450 by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

1,4-Bis[2-(3,5-dichloropyridyloxy)]benzene, an extremely potent modulator of mouse hepatic cytochrome P-450 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Simultaneous substitution of phenylalanine-305 and aspartate-318 of rat pregnane X receptor with the corresponding human residues abolishes the ability to transactivate the CYP3A23 promoter

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The pregnane X receptor binds to response elements in a genomic context-dependent manner, and PXR activator rifampicin selectively alters the binding among target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Pregnane X receptor prevents hepatorenal toxicity from cholesterol metabolites

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Regulation of a xenobiotic sulfonation cascade by nuclear pregnane X receptor (PXR).

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Cytoplasmic localization of pregnane X receptor and ligand-dependent nuclear translocation in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Regulation of Drug Transporter Gene Expression by Nuclear Receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Impact of dimethyl sulfoxide on expression of nuclear receptors and drug-inducible cytochromes P450 in primary rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Transcriptional Regulation of Human UGT1A1 Gene Expression: Activated Glucocorticoid Receptor Enhances constitutive Androstane Receptor/Pregnane X Receptor-Mediated UDP-Glucuronosyltransferase 1A1 Regulation with Glucocorticoid Receptor-Interacting P

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The induction of human UDP-glucuronosyltransferase 1A1 mediated through a distal enhancer module by flavonoids and xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Digoxin up-regulates multidrug resistance transporter (MDR1) mRNA and simultaneously down-regulates steroid xenobiotic receptor mRNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Bisphenol-A, an environmental estrogen, activates the human orphan nuclear receptor, steroid and xenobiotic receptor-mediated transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Induction of ABCC3 (MRP3) by pregnane X receptor activators

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Identification of amino acids in rat pregnane X receptor that determine species-specific activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The orphan nuclear receptor HNF4alpha determines PXR- and CAR-mediated xenobiotic induction of CYP3A4

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Role reversal: new insights from new ligands for the xenobiotic receptor CAR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Diverse roles of the nuclear orphan receptor CAR in regulating hepatic genes in response to phenobarbital

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A human and mouse pregnane X receptor reporter gene assay in combination with cytotoxicity measurements as a tool to evaluate species-specific CYP3A induction

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A novel distal enhancer module regulated by pregnane X receptor/constitutive androstane receptor is essential for the maximal induction of CYP2B6 gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Redundant pathways for negative feedback regulation of bile acid production

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Coactivator binding promotes the specific interaction between ligand and the pregnane X receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

2.1 A crystal structure of human PXR in complex with the St. John's wort compound hyperforin

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

St John's wort, a herbal antidepressant, activates the steroid X receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Molecular dynamics simulations of the human CAR ligand-binding domain: deciphering the molecular basis for constitutive activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Di-n-butyl phthalate activates constitutive androstane receptor and pregnane X receptor and enhances the expression of steroid-metabolizing enzymes in the liver of rat fetuses

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Structural determinants of constitutive androstane receptor required for its glucocorticoid receptor interacting protein-1-mediated nuclear accumulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Insights from a three-dimensional model into ligand binding to constitutive active receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Humanized xenobiotic response in mice expressing nuclear receptor SXR.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Reciprocal activation of xenobiotic response genes by nuclear receptors SXR/PXR and CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids.

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

A structural basis for constitutive activity in the human CAR/RXRalpha heterodimer

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The peptide near the C terminus regulates receptor CAR nuclear translocation induced by xenochemicals in mouse liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

The human pregnane X receptor: genomic structure and identification and functional characterization of natural allelic variants

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

In vivo activation of the human CYP3A4 promoter in mouse liver and regulation by pregnane X receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Tocotrienols activate the steroid and xenobiotic receptor, SXR, and selectively regulate expression of its target genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1080%2F03602530600786232

10.1080/03602530600786232

21 January 2018

Identifiers

DOI

1 reference

14 August 2017

1 reference