p63 and epithelial biology (Q34483460)

2 August 2017

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title

p63 and epithelial biology (English)

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2 August 2017

Jennifer A. Pietenpol

series ordinal

2

object named as

Jennifer A Pietenpol

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2 August 2017

Christopher E Barbieri

series ordinal

1

1 reference

PubMed ID

16406339

2 August 2017

language of work or name

English

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publication date

9 January 2006

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Experimental Cell Research

2 August 2017

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2 August 2017

312

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2 August 2017

6

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2 August 2017

695-706

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Cloning and chromosomal mapping of the human p53-related KET gene to chromosome 3q27 and its murine homolog Ket to mouse chromosome 16.

2 August 2017

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Cloning and functional analysis of human p51, which structurally and functionally resembles p53

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

7 January 2021

Surfing the p53 network

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p53 Signaling and cell cycle checkpoints

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

SAM as a protein interaction domain involved in developmental regulation

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p53 Family members p63 and p73 are SAM domain-containing proteins

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Backbone 1H, 13C and 15N resonance assignments for the 25.8 kDa DNA binding domain of the human p63 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

The Delta Np63 alpha phosphoprotein binds the p21 and 14-3-3 sigma promoters in vivo and has transcriptional repressor activity that is reduced by Hay-Wells syndrome-derived mutations

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p63 is a p53 homologue required for limb and epidermal morphogenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p63 is the molecular switch for initiation of an epithelial stratification program

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

A dominant-negative form of p63 is required for epidermal proliferation in zebrafish.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p63 Gene mutations in eec syndrome, limb-mammary syndrome, and isolated split hand-split foot malformation suggest a genotype-phenotype correlation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Split-hand/split-foot malformation is caused by mutations in the p63 gene on 3q27.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

TP63 gene mutation in ADULT syndrome

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Mutations in the p53 homolog p63: allele-specific developmental syndromes in humans.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Hay-Wells syndrome is caused by heterozygous missense mutations in the SAM domain of p63

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p63 identifies keratinocyte stem cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Association of p63 with proliferative potential in normal and neoplastic human keratinocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

IGFBP-3 is a direct target of transcriptional regulation by DeltaNp63alpha in squamous epithelium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p63 and p73 transactivate differentiation gene promoters in human keratinocytes

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Retinoic acid inhibits downregulation of DeltaNp63alpha expression during terminal differentiation of human primary keratinocytes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

deltaNp63alpha functions as both a positive and a negative transcriptional regulator and blocks in vitro differentiation of murine keratinocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p51/p63 Controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

A C-terminal inhibitory domain controls the activity of p63 by an intramolecular mechanism

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Adenovirus-mediated transfer of the p53 family genes, p73 and p51/p63 induces cell cycle arrest and apoptosis in colorectal cancer cell lines: potential application to gene therapy of colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Differential expression of p63 isoforms in normal tissues and neoplastic cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

CUSP/p63 expression in rat and human tissues

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Identification and tissue distribution of novel KET/p63 splice variants

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Ultraviolet radiation induces phosphorylation and ubiquitin-mediated degradation of DeltaNp63alpha

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Dominant negative p63 isoform expression in head and neck squamous cell carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Inhibition of epidermal growth factor receptor signaling decreases p63 expression in head and neck squamous carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Delta Np63 alpha expression is regulated by the phosphoinositide 3-kinase pathway.

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

The phosphoinositide 3-kinase pathway

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Function of bone morphogenetic protein signaling during mouse development

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Positive and negative regulation of ΔN-p63 promoter activity by p53 and ΔN-p63-α contributes to differential regulation of p53 target genes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Post-translational modification of p53 in tumorigenesis

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

RACK1 and stratifin target DeltaNp63alpha for a proteasome degradation in head and neck squamous cell carcinoma cells upon DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p53 gene family p51(p63)-encoded, secondary transactivator p51B(TAp63alpha) occurs without forming an immunoprecipitable complex with MDM2, but responds to genotoxic stress by accumulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p51A (TAp63gamma), a p53 homolog, accumulates in response to DNA damage for cell regulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

The protein stability and transcriptional activity of p63alpha are regulated by SUMO-1 conjugation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Altered sumoylation of p63alpha contributes to the split-hand/foot malformation phenotype

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

A link between p73 transcriptional activity and p73 degradation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

mdm2 expression is induced by wild type p53 activity

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Mdm2 promotes the rapid degradation of p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Regulation of p53 stability by Mdm2

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Hdmx and Mdm2 can repress transcription activation by p53 but not by p63.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

MDM2 and MDMX can interact differently with ARF and members of the p53 family

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Identification of p53 as a sequence-specific DNA-binding protein

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Definition of a consensus binding site for p53

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Sequence-specific transcriptional activation is essential for growth suppression by p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Differential protein expression, DNA binding and interaction with SV40 large tumour antigen implicate the p63-family of proteins in replicative senescence

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p53, the cellular gatekeeper for growth and division

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

14-3-3sigma is a p53-regulated inhibitor of G2/M progression

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Downregulation of 14-3-3sigma prevents clonal evolution and leads to immortalization of primary human keratinocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Perp is a p63-regulated gene essential for epithelial integrity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

The p53 family member genes are involved in the Notch signal pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Notch signaling: the demise of elegant simplicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Identification of pigment epithelium-derived factor as a direct target of the p53 family member genes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Loss of heterozygosity on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Somatic allelic loss at the DCC, APC, nm23-H1 and p53 tumor suppressor gene loci in human prostatic carcinoma.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Loss of heterozygosity on chromosome 17p and mutant p53 in HPV-negative cervical carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

AIS is an oncogene amplified in squamous cell carcinoma

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Role of the INK4a locus in tumor suppression and cell mortality.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Differential expression of p53 gene family members p63 and p73 in head and neck squamous tumorigenesis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

P63 and P73: P53 mimics, menaces and more

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Elevated expression of p63 protein in human esophageal squamous cell carcinomas

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

p63 and p73 are not required for the development and p53-dependent apoptosis of T cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Loss of p63 expression is associated with tumor progression in bladder cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Conditional inactivation of p63 by Cre-mediated excision

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

Xenopus p63 expression in early ectoderm and neurectoderm.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

On the shoulders of giants: p63, p73 and the rise of p53.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2005.11.028

10.1016/J.YEXCR.2005.11.028

7 January 2021

Identifiers

DOI

1 reference

2 August 2017

1 reference

PubMed ID

16406339