hERG potassium channels and cardiac arrhythmia (Q34504394)

2 August 2017

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title

hERG potassium channels and cardiac arrhythmia (English)

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2 August 2017

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Michael C Sanguinetti

series ordinal

1

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PubMed ID

16554806

2 August 2017

Martin Tristani-Firouzi

series ordinal

2

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PubMed ID

16554806

2 August 2017

language of work or name

English

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publication date

1 March 2006

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2 August 2017

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2 August 2017

440

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2 August 2017

463-469

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2 August 2017

7083

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https://scigraph.springernature.com/pub.10.1038/nature04710

2 August 2017

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cites work

A family of potassium channel genes related to eag in Drosophila and mammals

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

The potential for QT prolongation and proarrhythmia by non-antiarrhythmic drugs: clinical and regulatory implications. Report on a policy conference of the European Society of Cardiology

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https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

The Structure of the Potassium Channel: Molecular Basis of K+ Conduction and Selectivity

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Crystal structure and mechanism of a calcium-gated potassium channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

X-ray structure of a voltage-dependent K+ channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Crystal structure of a mammalian voltage-dependent Shaker family K+ channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

A novel role for HERG K+ channels: spike-frequency adaptation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Identification of two nervous system-specific members of the erg potassium channel gene family

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Erg1, erg2 and erg3 K channel subunits are able to form heteromultimers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

HERG, a human inward rectifier in the voltage-gated potassium channel family

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Molecular mechanism for an inherited cardiac arrhythmia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Ca(V)1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Biology of cardiac arrhythmias: ion channel protein trafficking

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

The dominant negative LQT2 mutation A561V reduces wild-type HERG expression

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Novel mechanism of HERG current suppression in LQT2: shift in voltage dependence of HERG inactivation.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Sudden death associated with short-QT syndrome linked to mutations in HERG.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

The open pore conformation of potassium channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Voltage sensor of Kv1.2: structural basis of electromechanical coupling

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

A structural basis for drug-induced long QT syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Physicochemical features of the HERG channel drug binding site

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Two isoforms of the mouse ether-a-go-go-related gene coassemble to form channels with properties similar to the rapidly activating component of the cardiac delayed rectifier K+ current

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Cyclic AMP regulates the HERG K(+) channel by dual pathways

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Coassembly of K(V)LQT1 and minK (IsK) proteins to form cardiac I(Ks) potassium channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Canine ventricular KCNE2 expression resides predominantly in Purkinje fibers.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Expression of multiple KCNE genes in human heart may enable variable modulation of I(Ks).

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

A comparison of currents carried by HERG, with and without coexpression of MiRP1, and the native rapid delayed rectifier current. Is MiRP1 the missing link?

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

A common polymorphism associated with antibiotic-induced cardiac arrhythmia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Outward membrane currents activated in the plateau range of potentials in cardiac Purkinje fibres

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Conductance and kinetics of delayed rectifier potassium channels in nodal cells of the rabbit heart.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Repolarization current in embryonic chick atrial heart cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Gating currents associated with intramembrane charge displacement in HERG potassium channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Fast and slow voltage sensor movements in HERG potassium channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Regional specificity of human ether-a'-go-go-related gene channel activation and inactivation gating.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Gating charges in the activation and inactivation processes of the HERG channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Transmembrane movement of the shaker K+ channel S4.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Structural basis of two-stage voltage-dependent activation in K+ channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Negative charges in the transmembrane domains of the HERG K channel are involved in the activation- and deactivation-gating processes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Molecular mapping of a site for Cd2+-induced modification of human ether-à-go-go-related gene (hERG) channel activation.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Critical assessment of a proposed model of Shaker

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transfer

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

The principle of gating charge movement in a voltage-dependent K+ channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Coupling between voltage sensors and activation gate in voltage-gated K+ channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Interactions between S4-S5 linker and S6 transmembrane domain modulate gating of HERG K+ channels

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Fast inactivation causes rectification of the IKr channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

The inward rectification mechanism of the HERG cardiac potassium channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Effects of outer mouth mutations on hERG channel function: a comparison with similar mutations in the Shaker channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Modulation of K+ current by frequency and external [K+]: a tale of two inactivation mechanisms.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Modulation of C-type inactivation by K+ at the potassium channel selectivity filter

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Cisapride-induced torsades de pointes

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

QT prolongation through hERG K(+) channel blockade: current knowledge and strategies for the early prediction during drug development

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Pentamidine-induced long QT syndrome and block of hERG trafficking

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Toward a pharmacophore for drugs inducing the long QT syndrome: insights from a CoMFA study of HERG K(+) channel blockers

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Characterization of HERG potassium channel inhibition using CoMSiA 3D QSAR and homology modeling approaches

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Predicting drug-hERG channel interactions that cause acquired long QT syndrome.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Understanding the Structure−Activity Relationship of the Human Ether-a-go-go-Related Gene Cardiac K+ Channel. A Model for Bad Behavior

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

A two-state homology model of the hERG K+ channel: application to ligand binding

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Exploring blocker binding to a homology model of the open hERG K+ channel using docking and molecular dynamics methods

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

herg1 gene and HERG1 protein are overexpressed in colorectal cancers and regulate cell invasion of tumor cells.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Discovery of a small molecule activator of the human ether-a-go-go-related gene (HERG) cardiac K+ channel

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Genetic basis and molecular mechanism for idiopathic ventricular fibrillation

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Simulation study of cellular electric properties in heart failure.

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Cardiac conduction defects associate with mutations in SCN5A

1 reference

https://api.crossref.org/works/10.1038%2FNATURE04710

7 January 2021

Identifiers

DOI

10.1038/NATURE04710

1 reference

2 August 2017

1 reference

PubMed ID

16554806