Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets. (Q34506525)

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English	Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets.	scientific article

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scholarly article

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18 January 2020

Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic mice overexpressing the gene for human IAPP and transplanted human islets (English)

1 reference

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18 January 2020

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Johan F Paulsson

1

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18 January 2020

author name string

A Andersson

2

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18 January 2020

P Westermark

3

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18 January 2020

G T Westermark

4

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18 January 2020

publication date

29 March 2006

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18 January 2020

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18 January 2020

49

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18 January 2020

1237-1246

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18 January 2020

6

1 reference

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18 January 2020

https://scigraph.springernature.com/pub.10.1007/s00125-006-0206-7

0 references

Congo red as a stain for fluorescence microscopy of amyloid.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0206-7

21 January 2018

Amyloid fibril protein nomenclature -- 2002.

1 reference

https://api.crossref.org/works/10.1007%2FS00125-006-0206-7

21 January 2018

Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proinsulin processing by the subtilisin-related proprotein convertases furin, PC2, and PC3

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic beta-cell granule peptides form heteromolecular complexes which inhibit islet amyloid polypeptide fibril formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protofibrillar islet amyloid polypeptide permeabilizes synthetic vesicles by a pore-like mechanism that may be relevant to type II diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of amyloid in human pancreatic islets transplanted to the liver and spleen of nude mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elevated circulating proinsulin levels in insulin-requiring diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid deposition of amyloid in human islets transplanted into nude mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular and functional characterization of amylin, a peptide associated with type 2 diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aberrant processing of human proislet amyloid polypeptide results in increased amyloid formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment with growth hormone and dexamethasone in mice transgenic for human islet amyloid polypeptide causes islet amyloidosis and beta-cell dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hyperproinsulinemia is associated with increased beta cell demand after hemipancreatectomy in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipid membranes modulate the structure of islet amyloid polypeptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of beta cell granule components on human islet amyloid polypeptide fibril formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of synthetic pro-islet amyloid polypeptide (proIAPP) 'amylin' by recombinant prohormone convertase enzymes, PC2 and PC3, in vitro.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amyloid fibril formation is progressive and correlates with beta-cell secretion in transgenic mouse isolated islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel peptide in the calcitonin gene related peptide family as an amyloid fibril protein in the endocrine pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet amyloid polypeptide-like immunoreactivity in the islet B cells of type 2 (non-insulin-dependent) diabetic and non-diabetic individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term elevation of free fatty acids leads to delayed processing of proinsulin and prohormone convertases 2 and 3 in the pancreatic beta-cell line MIN6.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet amyloid polypeptide-induced membrane leakage involves uptake of lipids by forming amyloid fibers

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholipid catalysis of diabetic amyloid assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mechanism of islet amyloid polypeptide toxicity is membrane disruption by intermediate-sized toxic amyloid particles.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of pro-islet amyloid polypeptide (proIAPP) by the prohormone convertase PC2

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet amyloid development in a mouse strain lacking endogenous islet amyloid polypeptide (IAPP) but expressing human IAPP

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long-term treatment with rosiglitazone and metformin reduces the extent of, but does not prevent, islet amyloid deposition in mice expressing the gene for human islet amyloid polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

B cell granule peptides affect human islet amyloid polypeptide (IAPP) fibril formation in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proinsulin as a marker for the development of NIDDM in Japanese-American men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Release of incompletely processed proinsulin is the cause of the disproportionate proinsulinemia of NIDDM.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of integral membrane peptidylglycine alpha-amidating monooxygenase in neuroendocrine cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carboxypeptidase activity in the insulin secretory granule

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Islet amyloid polypeptide in human insulinomas. Evidence for intracellular amyloidogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of free fatty acid on polymerization of islet amyloid polypeptide (IAPP) in vitro and on amyloid fibril formation in cultivated isolated islets of transgenic mice overexpressing human IAPP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differences in amyloid deposition in islets of transgenic mice expressing human islet amyloid polypeptide versus human islets implanted into nude mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/16570161

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S00125-006-0206-7

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16570161%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16570161%20AND%20SRC:MED&resulttype=core&format=json

18 January 2020

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