p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells. (Q34519958)

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17 January 2020

title

p38 mitogen-activated protein kinase mediates the Fas-induced mitochondrial death pathway in CD8+ T cells (English)

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17 January 2020

3

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Viswas Konasagara Nagaleekar

17 January 2020

4

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17 January 2020

8

Mercedes Rincón

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17 January 2020

7

Tina Thornton

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17 January 2020

author name string

Nicholas Farley

1

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17 January 2020

Gustavo Pedraza-Alva

2

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17 January 2020

Alexander Aronshtam

5

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17 January 2020

Troy Krahl

6

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17 January 2020

language of work or name

English

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publication date

1 March 2006

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Molecular and Cellular Biology

17 January 2020

published in

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17 January 2020

volume

26

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17 January 2020

issue

6

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17 January 2020

page(s)

2118-2129

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Effector CD4+ T cells generate intermediate caspase activity and cleavage of caspase-8 substrates

17 January 2020

cites work

1 reference

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p38alpha, but not p38beta, inhibits the phosphorylation and presence of c-FLIPS in DISC to potentiate Fas-mediated caspase-8 activation and type I apoptotic signaling

7 July 2018

1 reference

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Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling

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The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy

7 July 2018

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The role of the Bcl-2 family in the regulation of outer mitochondrial membrane permeability

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Regulation of Cbl molecular interactions by the co-receptor molecule CD43 in human T cells

7 July 2018

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p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons

7 July 2018

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p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-kappaB activity and Fas expression

7 July 2018

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p38 mitogen-activated protein kinase mediates bid cleavage, mitochondrial dysfunction, and caspase-3 activation during apoptosis induced by singlet oxygen but not by hydrogen peroxide

7 July 2018

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Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

7 July 2018

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Apoptosis signal-regulating kinase 1 (ASK1) induces neuronal differentiation and survival of PC12 cells

7 July 2018

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The p38 signal transduction pathway: activation and function

7 July 2018

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Activation of p38 mitogen-activated protein kinase in vivo selectively induces apoptosis of CD8(+) but not CD4(+) T cells

7 July 2018

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Regulation of c-Jun NH(2)-terminal kinase (Jnk) gene expression during T cell activation

7 July 2018

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BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

7 July 2018

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Bid-deficient mice are resistant to Fas-induced hepatocellular apoptosis

7 July 2018

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p38 mitogen-activated protein kinase is involved in Fas ligand expression.

7 July 2018

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JNK activation is not required for Fas-mediated apoptosis

7 July 2018

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Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

7 July 2018

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Tumor necrosis factor receptor and Fas signaling mechanisms.

7 July 2018

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An inhibitor of p38 mitogen-activated protein kinase protects neonatal cardiac myocytes from ischemia

7 July 2018

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TL1, a novel tumor necrosis factor-like cytokine, induces apoptosis in endothelial cells. Involvement of activation of stress protein kinases (stress-activated protein kinase and p38 mitogen-activated protein kinase) and caspase-3-like protease

7 July 2018

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Caspase-3 controls both cytoplasmic and nuclear events associated with Fas-mediated apoptosis in vivo

7 July 2018

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Essential requirement for caspase-8/FLICE in the initiation of the Fas-induced apoptotic cascade

7 July 2018

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7 July 2018

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Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally.

7 July 2018

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Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis

7 July 2018

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Differential requirement for caspase 9 in apoptotic pathways in vivo.

7 July 2018

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Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9

7 July 2018

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Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway

7 July 2018

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Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes

7 July 2018

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Two CD95 (APO-1/Fas) signaling pathways

7 July 2018

1 reference

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Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family

7 July 2018

1 reference

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Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade

7 July 2018

1 reference

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Fas induces cytoplasmic apoptotic responses and activation of the MKK7-JNK/SAPK and MKK6-p38 pathways independent of CPP32-like proteases.

7 July 2018

1 reference

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Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

7 July 2018

1 reference

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Sodium salicylate induces apoptosis via p38 mitogen-activated protein kinase but inhibits tumor necrosis factor-induced c-Jun N-terminal kinase/stress-activated protein kinase activation.

7 July 2018

1 reference

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Lack of a role for Jun kinase and AP-1 in Fas-induced apoptosis

7 July 2018

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Fas activation of the p38 mitogen-activated protein kinase signalling pathway requires ICE/CED-3 family proteases

7 July 2018

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CD95 (APO-1/Fas) induces activation of SAP kinases downstream of ICE-like proteases.

7 July 2018

1 reference

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Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

7 July 2018

1 reference

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MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

7 July 2018

1 reference

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Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins

7 July 2018

1 reference

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A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

7 July 2018

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Requirement of an ICE/CED-3 protease for Fas/APO-1-mediated apoptosis

7 July 2018

1 reference

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Pro-inflammatory cytokines and environmental stress cause p38 mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine

7 July 2018

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7 July 2018

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Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis

7 July 2018

1 reference

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J-aggregate formation of a carbocyanine as a quantitative fluorescent indicator of membrane potential

7 July 2018

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Lpr and gld: single gene models of systemic autoimmunity and lymphoproliferative disease

7 July 2018

1 reference

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The death receptor Fas (CD95/APO-1) mediates the deletion of T lymphocytes undergoing homeostatic proliferation.

7 July 2018

1 reference

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Role of p38 MAPK in the regulation of apoptosis signaling induced by TNF-alpha in differentiated PC12 cells

27 October 2018

1 reference

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c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 have distinct roles in CD8(+) T cell activation

27 October 2018

1 reference

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Differential involvement of p38 MAP kinase pathway and Bax translocation in the mitochondria-mediated cell death in TCR- and dexamethasone-stimulated thymocytes.

27 October 2018

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Analyzing JNK and p38 mitogen-activated protein kinase activity

27 October 2018

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MKK6 activates myocardial cell NF-kappaB and inhibits apoptosis in a p38 mitogen-activated protein kinase-dependent manner

27 October 2018

1 reference

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The p38 mitogen-activated protein kinase is activated by ligation of the T or B lymphocyte antigen receptors, Fas or CD40, but suppression of kinase activity does not inhibit apoptosis induced by antigen receptors

27 October 2018

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12 December 2020

Translocation of SAPK/JNK to mitochondria and interaction with Bcl-x(L) in response to DNA damage

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12 December 2020

Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation

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12 December 2020

Inhibition of p38 mitogen-activated protein kinase by insulin in cultured fetal neurons

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12 December 2020

Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153

1 reference

12 December 2020

10.1128/MCB.26.6.2118-2129.2006

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16507991%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16507991%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

PubMed publication ID

16507991

1 reference