Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch (Q34524602)

2 August 2017

title

Profiling of engineering hotspots identifies an allosteric CRISPR-Cas9 switch (English)

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2 August 2017

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6

Jennifer A Doudna

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2 August 2017

Dana C Nadler

2

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Christof Fellmann

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Christof Fellmann

4

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Avi Flamholz

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Avi Flamholz

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author name string

Benjamin L Oakes

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2 August 2017

Brett T Staahl

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2 August 2017

David F Savage

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2 August 2017

publication date

2 May 2016

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2 August 2017

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2 August 2017

volume

34

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2 August 2017

issue

6

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2 August 2017

page(s)

646-651

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STRUCTURAL BIOLOGY. A Cas9-guide RNA complex preorganized for target DNA recognition

2 August 2017

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

7 July 2018

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Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

7 July 2018

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Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system

7 July 2018

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Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells

7 July 2018

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DNA targeting specificity of RNA-guided Cas9 nucleases

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Hot spots for allosteric regulation on protein surfaces

7 July 2018

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Rapid diversification of cell signaling phenotypes by modular domain recombination

7 July 2018

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Synthetic protein scaffolds provide modular control over metabolic flux.

7 July 2018

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Linking the functions of unrelated proteins using a novel directed evolution domain insertion method

7 July 2018

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Evolution of the protein repertoire

7 July 2018

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Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha

7 July 2018

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Initial sequencing and analysis of the human genome

7 July 2018

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The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen

7 July 2018

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Crystallographic comparison of the estrogen and progesterone receptor's ligand binding domains

7 July 2018

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Specific interactions between the syntrophin PDZ domain and voltage-gated sodium channels

7 July 2018

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Ligand-activated site-specific recombination in mice

7 July 2018

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Transcriptional activation by tetracyclines in mammalian cells

7 July 2018

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Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

7 July 2018

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Guide RNA functional modules direct Cas9 activity and orthogonality

7 July 2018

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A yeast sensor of ligand binding.

27 October 2018

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Differential expression analysis for sequence count data

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Identifiers

DOI

10.1038/NBT.3528

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2 August 2017

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2 August 2017

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