C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector (Q34529451)

2 August 2017

title

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector (English)

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2 August 2017

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13

Eric S Lander

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2 August 2017

12

Aviv Regev

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2 August 2017

Jonathan S. Gootenberg

object named as

Jonathan S Gootenberg

2

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Eugene Koonin

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object named as

Eugene V Koonin

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2 August 2017

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Kira S Makarova

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2 August 2017

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Sergey Shmakov

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2 August 2017

1

Omar O Abudayyeh

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2 August 2017

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Leonid Minakhin

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2 August 2017

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Ian M Slaymaker

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2 August 2017

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Julia Joung

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2 August 2017

Silvana Konermann

3

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2 August 2017

David B T Cox

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2 August 2017

Ekaterina Semenova

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2 August 2017

Konstantin Severinov

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2 August 2017

Feng Zhang

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2 August 2017

language of work or name

English

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publication date

2 June 2016

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2 August 2017

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2 August 2017

volume

353

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2 August 2017

issue

6299

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2 August 2017

page(s)

aaf5573

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Direct CRISPR spacer acquisition from RNA by a natural reverse transcriptase-Cas1 fusion protein

2 August 2017

cites work

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7 July 2018

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7 July 2018

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7 July 2018

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Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6

7 July 2018

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The CRISPR-associated Csx1 protein of Pyrococcus furiosus is an adenosine-specific endoribonuclease

7 July 2018

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Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

7 July 2018

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Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease

7 July 2018

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7 July 2018

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Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system

7 July 2018

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An updated evolutionary classification of CRISPR-Cas systems

7 July 2018

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7 July 2018

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Engineering reprogrammable RNA-binding proteins for study and manipulation of the transcriptome

7 July 2018

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Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity

7 July 2018

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Cas9 specifies functional viral targets during CRISPR-Cas adaptation.

7 July 2018

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Integrase-mediated spacer acquisition during CRISPR-Cas adaptive immunity

7 July 2018

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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

7 July 2018

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Programmable RNA shredding by the type III-A CRISPR-Cas system of Streptococcus thermophilus.

7 July 2018

1 reference

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RNA targeting by the type III-A CRISPR-Cas Csm complex of Thermus thermophilus

7 July 2018

1 reference

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Target RNA capture and cleavage by the Cmr type III-B CRISPR-Cas effector complex

7 July 2018

1 reference

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Structural model of a CRISPR RNA-silencing complex reveals the RNA-target cleavage activity in Cmr4

7 July 2018

1 reference

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Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

7 July 2018

1 reference

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Structural biology. Crystal structure of a CRISPR RNA-guided surveillance complex bound to a ssDNA target

7 July 2018

1 reference

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Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli

7 July 2018

1 reference

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Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity

7 July 2018

1 reference

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Structure and activity of the RNA-targeting Type III-B CRISPR-Cas complex of Thermus thermophilus

7 July 2018

1 reference

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Comprehensive analysis of the HEPN superfamily: identification of novel roles in intra-genomic conflicts, defense, pathogenesis and RNA processing

7 July 2018

1 reference

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CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coli

7 July 2018

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In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus.

7 July 2018

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A novel interference mechanism by a type IIIB CRISPR-Cmr module in Sulfolobus.

7 July 2018

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Live virus-free or die: coupling of antivirus immunity and programmed suicide or dormancy in prokaryotes

7 July 2018

1 reference

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Crystal structure and nucleic acid-binding activity of the CRISPR-associated protein Csx1 of Pyrococcus furiosus

7 July 2018

1 reference

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Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria

7 July 2018

1 reference

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Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system

7 July 2018

1 reference

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A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

7 July 2018

1 reference

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Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli

7 July 2018

1 reference

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Essential features and rational design of CRISPR RNAs that function with the Cas RAMP module complex to cleave RNAs.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

Structure and Mechanism of the CMR Complex for CRISPR-Mediated Antiviral Immunity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

Designer RNA-binding proteins: New tools for manipulating the transcriptome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

Toxins-antitoxins: diversity, evolution and function

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

The Streptococcus thermophilus CRISPR/Cas system provides immunity in Escherichia coli

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

Evolution and classification of the CRISPR-Cas systems

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

Structural Basis of Defects in the Sacsin HEPN Domain Responsible for Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS)

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

The prospects for designer single-stranded RNA-binding proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

Self versus non-self discrimination during CRISPR RNA-directed immunity.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

RNA-guided RNA cleavage by a CRISPR RNA-Cas protein complex

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

CRISPR-based adaptive and heritable immunity in prokaryotes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

Fast and accurate short read alignment with Burrows-Wheeler transform

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

Small CRISPR RNAs guide antiviral defense in prokaryotes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

WebLogo: A Sequence Logo Generator

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5127784

7 July 2018

Identifiers

DOI

10.1126/SCIENCE.AAF5573

1 reference

2 August 2017

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2 August 2017

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