Global effect of inauhzin on human p53-responsive transcriptome (Q34533232)

2 August 2017

title

Global effect of inauhzin on human p53-responsive transcriptome (English)

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2 August 2017

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Jun-Ming Liao

1

1 reference

2 August 2017

Shelya X Zeng

series ordinal

2

1 reference

2 August 2017

Xiang Zhou

series ordinal

3

1 reference

2 August 2017

Hua Lu

series ordinal

4

1 reference

2 August 2017

language of work or name

English

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publication date

21 December 2012

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

12

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2 August 2017

page(s)

e52172

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Creative Commons Attribution 4.0 International

2 August 2017

copyright license

start time

21 December 2012

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth

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The sorafenib plus nutlin-3 combination promotes synergistic cytotoxicity in acute myeloid leukemic cells irrespectively of FLT3 and p53 status

7 July 2018

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Ribosomal protein S14 unties the MDM2-p53 loop upon ribosomal stress

7 July 2018

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A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53.

7 July 2018

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p53-Dependent induction of PVT1 and miR-1204.

7 July 2018

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Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress

7 July 2018

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7 July 2018

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MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma

7 July 2018

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microRNA-210 is upregulated in hypoxic cardiomyocytes through Akt- and p53-dependent pathways and exerts cytoprotective effects

7 July 2018

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Autoregulatory suppression of c-Myc by miR-185-3p

7 July 2018

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7 July 2018

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p53 downregulates Down syndrome-associated DYRK1A through miR-1246.

7 July 2018

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miR-605 joins p53 network to form a p53:miR-605:Mdm2 positive feedback loop in response to stress

7 July 2018

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7 July 2018

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Drug Off-Target Effects Predicted Using Structural Analysis in the Context of a Metabolic Network Model

7 July 2018

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p53 Impairs Endothelial Function by Transcriptionally Repressing Kruppel-Like Factor 2

7 July 2018

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p53 activates the PANK1/miRNA-107 gene leading to downregulation of CDK6 and p130 cell cycle proteins

7 July 2018

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miR-335 directly targets Rb1 (pRb/p105) in a proximal connection to p53-dependent stress response.

7 July 2018

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PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium

7 July 2018

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An improved empirical bayes approach to estimating differential gene expression in microarray time-course data: BETR (Bayesian Estimation of Temporal Regulation).

7 July 2018

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Awakening guardian angels: drugging the p53 pathway

7 July 2018

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Repression of the miR-17-92 cluster by p53 has an important function in hypoxia-induced apoptosis

7 July 2018

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7 July 2018

Modes of p53 regulation

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Blinded by the Light: The Growing Complexity of p53

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

p53 represses c-Myc through induction of the tumor suppressor miR-145

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

MDM2 antagonist nutlin-3 displays antiproliferative and proapoptotic activity in mantle cell lymphoma.

7 July 2018

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p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest

7 July 2018

1 reference

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Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

7 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Acetylation is indispensable for p53 activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Oxidative stress regulates IGF1R expression in vascular smooth-muscle cells via p53 and HDAC recruitment

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

A microRNA component of the p53 tumour suppressor network

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Wild-type p53: tumors can't stand it.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Restoration of p53 function leads to tumour regression in vivo

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Tip60-dependent acetylation of p53 modulates the decision between cell-cycle arrest and apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Modeling the therapeutic efficacy of p53 restoration in tumors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

p53 suppresses the Nrf2-dependent transcription of antioxidant response genes.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

The tumor suppressor protein p53 is required for neurite outgrowth and axon regeneration

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Distinct p53 acetylation cassettes differentially influence gene-expression patterns and cell fate.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Large scale real-time PCR validation on gene expression measurements from two commercial long-oligonucleotide microarrays

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Design issues for cDNA microarray experiments

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Statistical issues with microarrays: processing and analysis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Importance of replication in microarray gene expression studies: statistical methods and evidence from repetitive cDNA hybridizations

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Identification of BTG2, an antiproliferative p53-dependent component of the DNA damage cellular response pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

WAF1, a potential mediator of p53 tumor suppression

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

p53 mutations in human cancers

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3528779

Temporal dissection of p53 function in vitro and in vivo

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0052172

Acetylation of the p53 DNA-binding domain regulates apoptosis induction

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0052172

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23284922

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0052172

1 reference

2 August 2017

0 references

1 reference

2 August 2017

1 reference