MDM2 antagonist nutlin-3 displays antiproliferative and proapoptotic activity in mantle cell lymphoma. (Q39888339)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

title

MDM2 antagonist nutlin-3 displays antiproliferative and proapoptotic activity in mantle cell lymphoma (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

0 references

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

8

Stefania Pittaluga

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

author name string

Yoko Tabe

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Denise Sebasigari

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Linhua Jin

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Martina Rudelius

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Theresa Davies-Hill

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Kazunori Miyake

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Mark Raffeld

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

language of work or name

English

0 references

publication date

1 February 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

published in

Clinical Cancer Research

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

volume

15

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

issue

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

page(s)

933-942

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

Pharmacologic activation of p53-dependent and p53-independent apoptotic pathways in Hodgkin/Reed-Sternberg cells

20 January 2020

cites work

1 reference

12 December 2020

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

1 reference

12 December 2020

Mutation and genomic deletion status of ataxia telangiectasia mutated (ATM) and p53 confer specific gene expression profiles in mantle cell lymphoma

1 reference

12 December 2020

HDM2 antagonist Nutlin-3 disrupts p73-HDM2 binding and enhances p73 function.

1 reference

12 December 2020

p53 overexpression as a marker of poor prognosis in mantle cell lymphomas with t(11;14)(q13;q32)

1 reference

12 December 2020

Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies.

1 reference

12 December 2020

The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

1 reference

12 December 2020

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1 reference

12 December 2020

MDM2 antagonists induce p53-dependent apoptosis in AML: implications for leukemia therapy

1 reference

12 December 2020

Effect of an hdm-2 antagonist peptide inhibitor on cell cycle progression in p53-deficient H1299 human lung carcinoma cells.

1 reference

12 December 2020

Functional p53 signaling in Kaposi's sarcoma-associated herpesvirus lymphomas: implications for therapy.

1 reference

12 December 2020

p73-dependent induction of 14-3-3sigma increases the chemo-sensitivity of drug-resistant human breast cancers

1 reference

12 December 2020

Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesis

1 reference

12 December 2020

CDK4andMDM2Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-typeINK4a/ARFLocus

1 reference

12 December 2020

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

1 reference

12 December 2020

Bortezomib is synergistic with rituximab and cyclophosphamide in inducing apoptosis of mantle cell lymphoma cells in vitro and in vivo

1 reference

12 December 2020

Treatment of mantle cell lymphoma: current approach and future directions

1 reference

12 December 2020

p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis

1 reference

12 December 2020

Two new cell lines from B-prolymphocytic leukaemia: characterization by morphology, immunological markers, karyotype and Ig gene rearrangement

1 reference

12 December 2020

E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines

1 reference

12 December 2020

The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 status

1 reference

12 December 2020

Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

1 reference

12 December 2020

Blastic variant of mantle cell lymphoma: a rare but highly aggressive subtype

1 reference

12 December 2020

In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

1 reference

12 December 2020

ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

1 reference

12 December 2020

Potential role for concurrent abnormalities of the cyclin D1, p16CDKN2 and p15CDKN2B genes in certain B cell non-Hodgkin's lymphomas. Functional studies in a cell line (Granta 519).

1 reference

12 December 2020

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

1 reference

12 December 2020

CDK inhibitors: positive and negative regulators of G1-phase progression

1 reference

12 December 2020

The regulation of AMPK beta1, TSC2, and PTEN expression by p53: stress, cell and tissue specificity, and the role of these gene products in modulating the IGF-1-AKT-mTOR pathways

1 reference

12 December 2020

Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma

1 reference

12 December 2020

Z-138: a new mature B-cell acute lymphoblastic leukemia cell line from a patient with transformed chronic lymphocytic leukemia

1 reference

12 December 2020

p73 is a simian [correction of human] p53-related protein that can induce apoptosis

1 reference

12 December 2020

Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphoma

1 reference

12 December 2020

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

1 reference

12 December 2020

KSHV-positive solid lymphomas represent an extra-cavitary variant of primary effusion lymphoma

1 reference

12 December 2020

MDMX: a novel p53-binding protein with some functional properties of MDM2

1 reference

12 December 2020

p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas

1 reference

12 December 2020

Establishment and characterization of a new mantle cell lymphoma cell line, Mino

1 reference

12 December 2020

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1 reference

12 December 2020

Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphoma

1 reference

12 December 2020

Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia

1 reference

12 December 2020

Linking DNA damage to cell cycle checkpoints.

1 reference

12 December 2020

Levels of HdmX Expression Dictate the Sensitivity of Normal and Transformed Cells to Nutlin-3

1 reference

12 December 2020

p53-mediated growth suppression in response to Nutlin-3 in cyclin D1 transformed cells occurs independently of p21.

1 reference

12 December 2020

Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes

1 reference

12 December 2020

Hdmx modulates the outcome of p53 activation in human tumor cells

1 reference

12 December 2020

MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

1 reference

12 December 2020

Blastoid variants of mantle cell lymphoma: frequent bcl-1 rearrangements at the major translocation cluster region and tetraploid chromosome clones

1 reference

12 December 2020

Characterization of 4 mantle cell lymphoma cell lines

1 reference

12 December 2020

Apoptotic and growth-promoting activity of E2F modulated by MDM2

1 reference

12 December 2020

Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics

1 reference

12 December 2020

MDM2 promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma protein.

1 reference

12 December 2020

p16(INK4a) gene inactivation by deletions, mutations, and hypermethylation is associated with transformed and aggressive variants of non-Hodgkin's lymphomas

1 reference

12 December 2020

Evolution of functions within the p53/p63/p73 family.

1 reference

12 December 2020

Alterations of the cyclin D1/p16-pRB pathway in mantle cell lymphoma

1 reference

12 December 2020

Live or let die: the cell's response to p53

1 reference

12 December 2020

Functional integrity of the p53-mediated apoptotic pathway induced by the nongenotoxic agent nutlin-3 in B-cell chronic lymphocytic leukemia (B-CLL).

1 reference

12 December 2020

Regulating the p53 pathway: in vitro hypotheses, in vivo veritas

1 reference

12 December 2020

Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis

1 reference

12 December 2020

Inhibition of p53-murine double minute 2 interaction by nutlin-3A stabilizes p53 and induces cell cycle arrest and apoptosis in Hodgkin lymphoma

1 reference

12 December 2020

10.1158/1078-0432.CCR-08-0399

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19188164%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

1 reference