Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. (Q37343700)

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6 January 2020

title

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator (English)

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6 January 2020

14

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6 January 2020

David P. Lane

17

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6 January 2020

Nicholas J Westwood

18

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author name string

Sonia Lain

1

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6 January 2020

Jonathan J Hollick

2

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6 January 2020

Johanna Campbell

3

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Oliver D Staples

4

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6 January 2020

Maureen Higgins

5

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Mustapha Aoubala

6

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Anna McCarthy

7

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6 January 2020

Virginia Appleyard

8

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6 January 2020

Karen E Murray

9

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6 January 2020

Lee Baker

10

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6 January 2020

Alastair Thompson

11

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6 January 2020

Joanne Mathers

12

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6 January 2020

Stephen J Holland

13

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6 January 2020

Georgia Pass

15

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6 January 2020

Julie Woods

16

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6 January 2020

publication date

1 May 2008

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6 January 2020

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6 January 2020

volume

13

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6 January 2020

issue

5

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6 January 2020

page(s)

454-463

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Sirt1 modulates premature senescence-like phenotype in human endothelial cells

6 January 2020

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6 September 2017

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6 September 2017

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6 September 2017

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6 September 2017

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Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

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SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis

6 September 2017

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Structure and activity of enzymes that remove histone modifications

6 September 2017

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Small molecule regulation of Sir2 protein deacetylases

6 September 2017

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Pilot screening programme for small molecule activators of p53.

6 September 2017

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Proteins with two SUMO-like domains in chromatin-associated complexes: the RENi (Rad60-Esc2-NIP45) family

6 September 2017

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Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors.

6 September 2017

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Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin

6 September 2017

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Regulation of p53 by the ubiquitin-conjugating enzymes UbcH5B/C in vivo

6 September 2017

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Genetic and genomic approaches to identify and study the targets of bioactive small molecules.

6 September 2017

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Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

6 September 2017

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Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes

6 September 2017

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In vivo activation of the p53 pathway by small-molecule antagonists of MDM2

6 September 2017

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Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

6 September 2017

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Histone H2AX in DNA damage and repair.

6 September 2017

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

6 September 2017

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Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton

6 September 2017

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Restoration of silencing in Saccharomyces cerevisiae by tethering of a novel Sir2-interacting protein, Esc8.

6 September 2017

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Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence

6 September 2017

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Identification of a small molecule inhibitor of Sir2p

6 September 2017

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

6 September 2017

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Negative control of p53 by Sir2alpha promotes cell survival under stress

6 September 2017

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6 September 2017

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Post-translational modifications and activation of p53 by genotoxic stresses

6 September 2017

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Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins

6 September 2017

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

6 September 2017

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Characterization of a panel of novel anti-p21Waf1/Cip1 monoclonal antibodies and immunochemical analysis of p21Waf1/Cip1 expression in normal human tissues.

6 September 2017

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Immunochemical analysis of the p53 oncoprotein in matched primary and metastatic human tumours.

6 September 2017

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SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents

6 September 2017

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Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

14 September 2017

1 reference

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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage

14 September 2017

1 reference

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Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.

14 September 2017

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Different effects of p14ARF on the levels of ubiquitinated p53 and Mdm2 in vivo.

14 September 2017

1 reference

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Effects on normal fibroblasts and neuroblastoma cells of the activation of the p53 response by the nuclear export inhibitor leptomycin B.

28 September 2017

1 reference

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Genomic profiling of drug sensitivities via induced haploinsufficiency.

28 September 2017

1 reference

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Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress

26 June 2018

1 reference

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Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases

2 September 2018

1 reference

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Structural identification of 2'- and 3'-O-acetyl-ADP-ribose as novel metabolites derived from the Sir2 family of beta -NAD+-dependent histone/protein deacetylases

2 September 2018

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Post-translational modification of p53.

2 September 2018

1 reference

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p14ARF homozygous deletion or MDM2 overexpression in Burkitt lymphoma lines carrying wild type p53

2 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18455128

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The assessment of proliferating cell nuclear antigen (PCNA) immunostaining in primary gastrointestinal lymphomas and its relationship to histological grade, S+G2+M phase fraction (flow cytometric analysis) and prognosis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18455128

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

DNA damage triggers DRB-resistant phosphorylation of human p53 at the CK2 site

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/18455128

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CCR.2008.03.004

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18455128%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18455128%20AND%20SRC:MED&resulttype=core&format=json

6 January 2020

1 reference