Conditional alleles in mice: practical considerations for tissue-specific knockouts (Q34540094)

2 August 2017

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title

Conditional alleles in mice: practical considerations for tissue-specific knockouts (English)

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2 August 2017

Kin-Ming Kwan

1

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2 August 2017

publication date

1 February 2002

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2 August 2017

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2 August 2017

volume

32

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2 August 2017

issue

2

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2 August 2017

page(s)

49-62

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Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

2 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Gene recombination in postmitotic cells. Targeted expression of Cre recombinase provokes cardiac-restricted, site-specific rearrangement in adult ventricular muscle in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Pax6 activity in the lens primordium is required for lens formation and for correct placement of a single retina in the eye

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Neurotrophin-3 is required for proper cerebellar development

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Bypass of lethality with mosaic mice generated by Cre– loxP -mediated recombination

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Skin and hair follicle integrity is crucially dependent on beta 1 integrin expression on keratinocytes

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

A chimeric Cre recombinase inducible by synthetic,but not by natural ligands of the glucocorticoid receptor

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Role of brain insulin receptor in control of body weight and reproduction

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

A simple assay to determine the functionality of Cre or FLP recombination targets in genomic manipulation constructs.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Improved properties of FLP recombinase evolved by cycling mutagenesis

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Liver-specific inactivation of the abetalipoproteinemia gene completely abrogates very low density lipoprotein/low density lipoprotein production in a viable conditional knockout mouse

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Conditional gene targeting in macrophages and granulocytes using LysMcre mice.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Analysis of C-MYC function in normal cells via conditional gene-targeted mutation

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Flp recombinase promotes site-specific DNA recombination in embryonic stem cells and transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Widespread recombinase expression using FLPeR (flipper) mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

A dual role of erbB2 in myelination and in expansion of the schwann cell precursor pool

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

A cardiac myocyte vascular endothelial growth factor paracrine pathway is required to maintain cardiac function

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

A splicing switch and gain-of-function mutation in FgfR2-IIIc hemizygotes causes Apert/Pfeiffer-syndrome-like phenotypes

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Tissue-specific targeting of the pthrp gene: the generation of mice with floxed alleles

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

T-cell-specific deletion of a polypeptide N-acetylgalactosaminyl-transferase gene by site-directed recombination

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Pax5/BSAP maintains the identity of B cells in late B lymphopoiesis.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Formation of temporal memory requires NMDA receptors within CA1 pyramidal neurons

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Selective ablation of retinoid X receptor alpha in hepatocytes impairs their lifespan and regenerative capacity

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Cortex-restricted disruption of NMDAR1 impairs neuronal patterns in the barrel cortex

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Loss of genomic methylation causes p53-dependent apoptosis and epigenetic deregulation

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Epigenetic regulation of gene structure and function with a cell-permeable Cre recombinase.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Removal of the floxed neo gene from a conditional knockout allele by the adenoviral Cre recombinase in vivo.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Inducible site-specific recombination in the brain

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Targeted oncogene activation by site-specific recombination in transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Efficient in vivo manipulation of mouse genomic sequences at the zygote stage

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Mitochondrial transcription factor A is necessary for mtDNA maintenance and embryogenesis in mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Disruption of the c/ebp alpha gene in adult mouse liver

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Neonatally induced inactivation of the vascular cell adhesion molecule 1 gene impairs B cell localization and T cell-dependent humoral immune response

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Fgf8 signalling from the AER is essential for normal limb development.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Genetic modification of survival in tissue-specific knockout mice with mitochondrial cardiomyopathy

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Endothelial cell-specific knockout of connexin 43 causes hypotension and bradycardia in mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Conditional genome alteration in mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Development of mammary adenocarcinomas by tissue-specific knockout of Brca2 in mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Pax6 is required for the multipotent state of retinal progenitor cells

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Genetic evidence for selective transport of opsin and arrestin by kinesin-II in mammalian photoreceptors

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Mouse model for lung tumorigenesis through Cre/lox controlled sporadic activation of the K-Ras oncogene

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

An Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Essential role for TrkB receptors in hippocampus-mediated learning

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Fgf8 is required for outgrowth and patterning of the limbs

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Cre recombinase: The universal reagent for genome tailoring

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Asymmetric and node-specific nodal expression patterns are controlled by two distinct cis-acting regulatory elements

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Recombinase-mediated gene activation and site-specific integration in mammalian cells

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Tissue- and site-specific DNA recombination in transgenic mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Deficient T cell fate specification in mice with an induced inactivation of Notch1.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Conditional ablation of beta1 integrin in skin. Severe defects in epidermal proliferation, basement membrane formation, and hair follicle invagination

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Conditional deletion of brain-derived neurotrophic factor in the postnatal brain leads to obesity and hyperactivity

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Sustained somatic gene inactivation by viral transfer of Cre recombinase.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Inducible inactivation of hepatic LRP gene by cre-mediated recombination confirms role of LRP in clearance of chylomicron remnants

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Keratinocyte-specific ablation of Stat3 exhibits impaired skin remodeling, but does not affect skin morphogenesis

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Efficient FLP recombination in mouse ES cells and oocytes.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Temporally and spatially regulated somatic mutagenesis in mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Rapid colorectal adenoma formation initiated by conditional targeting of the Apc gene.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Impaired insulin secretion and beta-cell loss in tissue-specific knockout mice with mitochondrial diabetes.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Conditional inactivation of Fgf4 reveals complexity of signalling during limb bud development

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Hepatocyte nuclear factor 3beta (Foxa2) is dispensable for maintaining the differentiated state of the adult hepatocyte

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Tissue-specific deletion of Foxa2 in pancreatic beta cells results in hyperinsulinemic hypoglycemia

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Functional competence of T cells in the absence of glycosylphosphatidylinositol-anchored proteins caused by T cell-specific disruption of the Pig-a gene

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Tissue-specific knockout of the mouse Pig-a gene reveals important roles for GPI-anchored proteins in skin development.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Pancreatic beta-cell-specific targeted disruption of glucokinase gene. Diabetes mellitus due to defective insulin secretion to glucose

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Proliferation, but not growth, blocked by conditional deletion of 40S ribosomal protein S6

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Dilated cardiomyopathy and atrioventricular conduction blocks induced by heart-specific inactivation of mitochondrial DNA gene expression.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Inactivation of Notch 1 in immature thymocytes does not perturb CD4 or CD8T cell development.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Direct removal in the mouse of a floxed neo gene from a three-loxP conditional knockout allele by two novel approaches

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Normal growth and development in the absence of hepatic insulin-like growth factor I

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Engineering chromosomal rearrangements in mice

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Pituitary-specific knockout of steroidogenic factor 1.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Hypomorphic phenotype in mice with pituitary-specific knockout of steroidogenic factor 1.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

1 reference

https://api.crossref.org/works/10.1002%2FGENE.10068

7 January 2021

Identifiers

DOI

10.1002/GENE.10068

1 reference

2 August 2017

1 reference