Agonism and antagonism at the insulin receptor (Q34540334)

2 August 2017

title

Agonism and antagonism at the insulin receptor (English)

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2 August 2017

Pierre De Meyts

10

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Blagoy Blagoev

object named as

Blagoy Blagoev

7

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author name string

Louise Knudsen

1

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2 August 2017

Bo Falck Hansen

2

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2 August 2017

Pia Jensen

3

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2 August 2017

Thomas Åskov Pedersen

4

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2 August 2017

Kirsten Vestergaard

5

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2 August 2017

Lauge Schäffer

6

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2 August 2017

Martin B Oleksiewicz

8

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2 August 2017

Vladislav V Kiselyov

9

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2 August 2017

language of work or name

English

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publication date

27 December 2012

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2 August 2017

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2 August 2017

volume

7

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2 August 2017

issue

12

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2 August 2017

page(s)

e51972

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Creative Commons Attribution 4.0 International

2 August 2017

copyright license

start time

27 December 2012

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Comparison of intracellular signalling by insulin and the hypermitogenic AspB10 analogue in MCF‐7 breast adenocarcinoma cells

7 July 2018

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S961, an insulin receptor antagonist causes hyperinsulinemia, insulin-resistance and depletion of energy stores in rats

7 July 2018

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Structural resolution of a tandem hormone-binding element in the insulin receptor and its implications for design of peptide agonists

7 July 2018

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Synchronization in G0/G1 enhances the mitogenic response of cells overexpressing the human insulin receptor A isoform to insulin

7 July 2018

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MCF-7 human mammary adenocarcinoma cells exhibit augmented responses to human insulin on a collagen IV surface

7 July 2018

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7 July 2018

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Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation

7 July 2018

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Activation of the insulin receptor by insulin and a synthetic peptide leads to divergent metabolic and mitogenic signaling and responses

7 July 2018

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7 July 2018

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Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

7 July 2018

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Structure of the insulin receptor ectodomain reveals a folded-over conformation

7 July 2018

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Tyrphostins and other tyrosine kinase inhibitors

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Critical nodes in signalling pathways: insights into insulin action

7 July 2018

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Assembly of high-affinity insulin receptor agonists and antagonists from peptide building blocks

7 July 2018

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Structural biology of insulin and IGF1 receptors: implications for drug design

7 July 2018

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Protein tyrosine kinase structure and function

7 July 2018

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Sustained signalling from the insulin receptor after stimulation with insulin analogues exhibiting increased mitogenic potency

7 July 2018

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Receptor dimerization determines the effects of growth hormone in primary rat adipocytes and cultured human IM-9 lymphocytes

7 July 2018

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The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity, and its relevance to mitogenic versus metabolic signalling.

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Semisynthesis and biological activity of porcine [LeuB24]insulin and [LeuB25]insulin

7 July 2018

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Characterization of [LeuB-24]- and [LeuB-25]-insulin analogues. Receptor binding and biological activity

7 July 2018

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Insulin activates a tyrosine-specific protein kinase in extracts of 3T3-L1 adipocytes and human placenta.

7 July 2018

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Insulin interactions with its receptors: experimental evidence for negative cooperativity.

7 July 2018

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High-level expression of human insulin receptor cDNA in mouse NIH 3T3 cells

7 July 2018

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Reversal of insulin-induced negative cooperativity by monoclonal antibodies that stabilize the slowly dissociating ("Ksuper") state of the insulin receptor.

7 July 2018

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

7 July 2018

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Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity

7 July 2018

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7 July 2018

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Insulin and insulin-like growth factor I regulate the same biological functions in HEP-G2 cells via their own specific receptors

7 July 2018

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Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

7 July 2018

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Antagonistic effects of a covalently dimerized insulin derivative on insulin receptors in 3T3-L1 adipocytes

7 July 2018

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Rational design of potent antagonists to the human growth hormone receptor

7 July 2018

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A panel of monoclonal antibodies for the type I insulin-like growth factor receptor. Epitope mapping, effects on ligand binding, and biological activity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531387

Kinetic parameters of transport of 3-O-methylglucose and glucose in adipocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531387

A thermodynamic study of ligand binding to the first three domains of the human insulin receptor: relationship between the receptor alpha-chain C-terminal peptide and the site 1 insulin mimetic peptides.

7 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051972

A novel high-affinity peptide antagonist to the insulin receptor

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531387

Inhibition of adipocyte differentiation by resistin-like molecule alpha. Biochemical characterization of its oligomeric nature

27 October 2018

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Peptides identify the critical hotspots involved in the biological activation of the insulin receptor

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3531387

Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin

27 October 2018

1 reference

Crossref

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0051972

Characterization of a mutant human insulin species

21 January 2018

1 reference

12 December 2020

Impaired negative cooperativity of the semisynthetic analogues human [LeuB24]- and [LeuB25]-insulins

1 reference

12 December 2020

Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor

1 reference

12 December 2020

[LeuB24]- and [LeuB25]insulins are not antagonists of lipogenesis in adipocytes

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12 December 2020

LeuB24insulin is an insulin agonist at the liver in vivo

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12 December 2020

Relative influence of testosterone and insulin in the regulation of prostatic cell proliferation and growth

1 reference

12 December 2020

A model for insulin binding to the insulin receptor

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0051972

Identifiers

DOI

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2 August 2017

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2 August 2017

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