PTEN: The down side of PI 3-kinase signalling. (Q34540849)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11858936%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

review article

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title

PTEN: The down side of PI 3-kinase signalling (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11858936%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

1

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7 December 2019

author name string

C Peter Downes

series ordinal

2

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7 December 2019

publication date

1 April 2002

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7 December 2019

number of pages

11

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inferred from page(s)

published in

Cellular Signalling

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7 December 2019

volume

14

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7 December 2019

issue

4

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7 December 2019

page(s)

285-295

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7 December 2019

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PIPkins1, their substrates and their products: new functions for old enzymes.

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Signaling by distinct classes of phosphoinositide 3-kinases

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Phosphoinositide binding domains: embracing 3-phosphate

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7 January 2021

PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity

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7 January 2021

Mutations of the human PTEN gene

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7 January 2021

PTEN: life as a tumor suppressor

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PTEN, a unique tumor suppressor gene

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7 January 2021

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

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7 January 2021

Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain

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7 January 2021

Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

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7 January 2021

Phosphorylation of the PTEN tail regulates protein stability and function

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7 January 2021

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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7 January 2021

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

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7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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7 January 2021

5' phospholipid phosphatase SHIP-2 causes protein kinase B inactivation and cell cycle arrest in glioblastoma cells

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7 January 2021

PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway

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7 January 2021

Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

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7 January 2021

Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway

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7 January 2021

PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells

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7 January 2021

The tumor suppressor PTEN negatively regulates insulin signaling in 3T3-L1 adipocytes

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7 January 2021

The PTEN/MMAC1 tumor suppressor phosphatase functions as a negative regulator of the phosphoinositide 3-kinase/Akt pathway

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7 January 2021

Genetic control of cell size

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7 January 2021

Phosphoinositide 3-kinases: a conserved family of signal transducers

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7 January 2021

Drosophila PTEN regulates cell growth and proliferation through PI3K-dependent and -independent pathways

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7 January 2021

Regulation of the insulin-like developmental pathway of Caenorhabditis elegans by a homolog of the PTEN tumor suppressor gene

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7 January 2021

Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway

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7 January 2021

The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway

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7 January 2021

The C. elegans PTEN homolog, DAF-18, acts in the insulin receptor-like metabolic signaling pathway

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7 January 2021

Regulation of dauer larva development in Caenorhabditis elegans by daf-18, a homologue of the tumour suppressor PTEN

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7 January 2021

Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

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7 January 2021

A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y

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7 January 2021

SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival

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7 January 2021

The lipid phosphatase SHIP2 controls insulin sensitivity

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7 January 2021

Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities

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7 January 2021

Phospholipid signalling in the nucleus. Een DAG uit het leven van de inositide signalering in de nucleus

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7 January 2021

SIGNAL TRANSDUCTION:Signals to Move Cells

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7 January 2021

Akt/PKB localisation and 3' phosphoinositide generation at sites of epithelial cell-matrix and cell-cell interaction

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7 January 2021

Chemoattractant-mediated transient activation and membrane localization of Akt/PKB is required for efficient chemotaxis to cAMP in Dictyostelium

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7 January 2021

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis

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7 January 2021

Shc and FAK differentially regulate cell motility and directionality modulated by PTEN.

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7 January 2021

Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN

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7 January 2021

Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases

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7 January 2021

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

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7 January 2021

Insulin-like growth factor I stimulates tyrosine phosphorylation of p130(Cas), focal adhesion kinase, and paxillin. Role of phosphatidylinositol 3'-kinase and formation of a p130(Cas).Crk complex

1 reference

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7 January 2021

PTEN coordinates G(1) arrest by down-regulating cyclin D1 via its protein phosphatase activity and up-regulating p27 via its lipid phosphatase activity in a breast cancer model

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

1 reference

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7 January 2021

Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes

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7 January 2021

C2-domains, structure and function of a universal Ca2+-binding domain

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7 January 2021

The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

Inhibition of H-Ras transformation by the PTEN/MMAC1/TEP1 tumor suppressor gene

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

Combinatorial control of the specificity of protein tyrosine phosphatases

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7 January 2021

Mammalian MAP kinase signalling cascades

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7 January 2021

Receptor tyrosine kinases: specific outcomes from general signals

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7 January 2021

AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide-dependent phosphorylation

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7 January 2021

Phosphoinositide-regulated kinases and phosphoinositide phosphatases.

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7 January 2021

Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN.

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7 January 2021

PTEN controls tumor-induced angiogenesis

1 reference

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7 January 2021

Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells

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7 January 2021

Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf signaling

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7 January 2021

Adenovirus endocytosis via alpha(v) integrins requires phosphoinositide-3-OH kinase

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7 January 2021

Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C.

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7 January 2021

eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation

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7 January 2021

Signalling through phosphoinositide 3-kinases: the lipids take centre stage

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7 January 2021

Cellular signaling: pivoting around PDK-1.

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7 January 2021

Cellular survival: a play in three Akts

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7 January 2021

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

1 reference

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7 January 2021

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2)

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

Altered PTEN expression as a diagnostic marker for the earliest endometrial precancers

1 reference

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7 January 2021

PDZ domains in synapse assembly and signalling

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7 January 2021

PDZ proteins organize synaptic signaling pathways

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7 January 2021

PDZ domains: fundamental building blocks in the organization of protein complexes at the plasma membrane

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7 January 2021

Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins

1 reference

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7 January 2021

Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

Mutation and expression analyses reveal differential subcellular compartmentalization of PTEN in endocrine pancreatic tumors compared to normal islet cells

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

A role for nuclear PTEN in neuronal differentiation.

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanismsin haematological malignancies

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast

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https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

Novel vitamin D(3) analog, 21-(3-methyl-3-hydroxy-butyl)-19-nor D(3), that modulates cell growth, differentiation, apoptosis, cell cycle, and induction of PTEN in leukemic cells

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

Tumor suppressor and anti-inflammatory actions of PPARgamma agonists are mediated via upregulation of PTEN.

1 reference

https://api.crossref.org/works/10.1016%2FS0898-6568%2801%2900234-0

7 January 2021

PTEN expression causes feedback upregulation of insulin receptor substrate 2

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7 January 2021

10.1016/S0898-6568(01)00234-0

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11858936%20AND%20SRC:MED&resulttype=core&format=json

7 December 2019

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