Targeted reduction of vascular Msx1 and Msx2 mitigates arteriosclerotic calcification and aortic stiffness in LDLR-deficient mice fed diabetogenic diets (Q34545428)

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English	Targeted reduction of vascular Msx1 and Msx2 mitigates arteriosclerotic calcification and aortic stiffness in LDLR-deficient mice fed diabetogenic diets	scientific article

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Europe PubMed Central

2 August 2017

Targeted reduction of vascular Msx1 and Msx2 mitigates arteriosclerotic calcification and aortic stiffness in LDLR-deficient mice fed diabetogenic diets (English)

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Europe PubMed Central

2 August 2017

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Dwight A. Towler

10

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13 June 2020

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Su-Li Cheng

1

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13 June 2020

Abraham Behrmann

2

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13 June 2020

Jian-Su Shao

3

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13 June 2020

Bindu Ramachandran

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13 June 2020

Karen Krchma

5

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13 June 2020

Yoanna Bello Arredondo

6

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13 June 2020

Attila Kovacs

7

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13 June 2020

Megan Mead

8

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13 June 2020

Robert Maxson

9

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13 June 2020

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23 July 2014

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2 August 2017

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12

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13 June 2020

63

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13 June 2020

4326-4337

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13 June 2020

12

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13 June 2020

describes a project that uses

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11 June 2022

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Osteogenic transcription factors and proto-oncogene regulate bone sialoprotein gene transcription

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Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

1 reference

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TNFR1-activated reactive oxidative species signals up-regulate osteogenic Msx2 programs in aortic myofibroblasts.

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7 July 2018

Vascular calcification and aortic fibrosis: a bifunctional role for osteopontin in diabetic arteriosclerosis

1 reference

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7 July 2018

Activation of vascular smooth muscle parathyroid hormone receptor inhibits Wnt/beta-catenin signaling and aortic fibrosis in diabetic arteriosclerosis

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Smooth muscle cells give rise to osteochondrogenic precursors and chondrocytes in calcifying arteries

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Dysregulation of antioxidant mechanisms contributes to increased oxidative stress in calcific aortic valvular stenosis in humans.

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Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium

1 reference

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7 July 2018

A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells

1 reference

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7 July 2018

Msx2 exerts bone anabolism via canonical Wnt signaling

1 reference

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7 July 2018

Oxidative stress induces vascular calcification through modulation of the osteogenic transcription factor Runx2 by AKT signaling.

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Concerted action of Msx1 and Msx2 in regulating cranial neural crest cell differentiation during frontal bone development

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Msx1 and Msx2 regulate survival of secondary heart field precursors and post-migratory proliferation of cardiac neural crest in the outflow tract

1 reference

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Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

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Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals

1 reference

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Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene.

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BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop

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Multilineage potential of cells from the artery wall.

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Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex

1 reference

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A transcriptional response to Wnt protein in human embryonic carcinoma cells

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Activation of AXIN2 expression by beta-catenin-T cell factor. A feedback repressor pathway regulating Wnt signaling

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4237989

7 July 2018

Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4237989

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27 October 2018

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1 reference

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27 October 2018

Conditional alleles of Msx1 and Msx2.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4237989

27 October 2018

Combined deficiencies of Msx1 and Msx2 cause impaired patterning and survival of the cranial neural crest

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4237989

27 October 2018

MSX2 promotes osteogenesis and suppresses adipogenic differentiation of multipotent mesenchymal progenitors.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4237989

27 October 2018

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27 October 2018

Diet-induced diabetes activates an osteogenic gene regulatory program in the aortas of low density lipoprotein receptor-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/25056439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteo/chondrocytic transcription factors and their target genes exhibit distinct patterns of expression in human arterial calcification

1 reference

https://pubmed.ncbi.nlm.nih.gov/25056439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25056439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidized low-density lipoprotein promotes osteoblast differentiation in primary cultures of vascular smooth muscle cells by up-regulating Osterix expression in an Msx2-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/25056439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Wnt4/β-Catenin Signaling Induces VSMC Proliferation and Is Associated With Intimal Thickening

1 reference

https://pubmed.ncbi.nlm.nih.gov/25056439

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.2337/DB14-0326

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Europe PubMed Central

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13 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25056439%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25056439%20AND%20SRC:MED&resulttype=core&format=json

13 June 2020

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