Evidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradation (Q34545941)

2 August 2017

Evidence that the human cytomegalovirus IE2-86 protein binds mdm2 and facilitates mdm2 degradation (English)

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2 August 2017

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Zhigang Zhang

1

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2 August 2017

David L Evers

2

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2 August 2017

Joseph F McCarville

3

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2 August 2017

Jean-Christophe Dantonel

4

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2 August 2017

Shu-Mei Huong

5

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2 August 2017

Eng-Shang Huang

6

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2 August 2017

language of work or name

English

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publication date

1 April 2006

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2 August 2017

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2 August 2017

80

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2 August 2017

8

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2 August 2017

3833-3843

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describes a project that uses

2 August 2017

ImageQuant

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC1440454/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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The acidic tail domain of human Cdc34 is required for p27Kip1 ubiquitination and complementation of a cdc34 temperature sensitive yeast strain.

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Human cytomegalovirus IE1-72 activates ataxia telangiectasia mutated kinase and a p53/p21-mediated growth arrest response

7 July 2018

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A novel degron-mediated degradation of the RTG pathway regulator, Mks1p, by SCFGrr1.

7 July 2018

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Inhibition of cell division by the human cytomegalovirus IE86 protein: role of the p53 pathway or cyclin-dependent kinase 1/cyclin B1.

7 July 2018

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The putative zinc finger of the human cytomegalovirus IE2 86-kilodalton protein is dispensable for DNA binding and autorepression, thereby demarcating a concise core domain in the C terminus of the protein

7 July 2018

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7 July 2018

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Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter

7 July 2018

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MDM2 is a negative regulator of p21WAF1/CIP1, independent of p53.

7 July 2018

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Inhibition of human cytomegalovirus replication by small interfering RNAs

7 July 2018

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p53-independent functions of MDM2.

7 July 2018

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Functional profiling of a human cytomegalovirus genome

7 July 2018

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Interactions between Human Cytomegalovirus IE1-72 and Cellular p107: Functional Domains and Mechanisms of Up-Regulation of Cyclin E/cdk2 Kinase Activity

7 July 2018

1 reference

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Murine cytomegalovirus m41 open reading frame encodes a Golgi-localized antiapoptotic protein

7 July 2018

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Physical and functional interactions between PML and MDM2

7 July 2018

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Proteasome-dependent, ubiquitin-independent degradation of the Rb family of tumor suppressors by the human cytomegalovirus pp71 protein

7 July 2018

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The p53-Mdm2 module and the ubiquitin system.

7 July 2018

1 reference

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Cell cycle arrest by human cytomegalovirus 86-kDa IE2 protein resembles premature senescence

7 July 2018

1 reference

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Human cytomegalovirus immediate early proteins and cell growth control

7 July 2018

1 reference

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Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt.

7 July 2018

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A LIM-homeodomain code for development and evolution of forebrain connectivity

7 July 2018

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Effect of the human cytomegalovirus IE86 protein on expression of E2F-responsive genes: a DNA microarray analysis

7 July 2018

1 reference

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A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 activation

7 July 2018

1 reference

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Human cytomegalovirus up-regulates the phosphatidylinositol 3-kinase (PI3-K) pathway: inhibition of PI3-K activity inhibits viral replication and virus-induced signaling

7 July 2018

1 reference

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Post-translational modifications and activation of p53 by genotoxic stresses

7 July 2018

1 reference

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Degradation of p21cip1 in cells productively infected with human cytomegalovirus

7 July 2018

1 reference

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The human cytomegalovirus immediate early 2 protein dissociates cellular DNA synthesis from cyclin-dependent kinase activation

7 July 2018

1 reference

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pRB induces Sp1 activity by relieving inhibition mediated by MDM2.

7 July 2018

1 reference

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Human cytomegalovirus with IE-2 (UL122) deleted fails to express early lytic genes

7 July 2018

1 reference

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Viral mechanisms of immune evasion

7 July 2018

1 reference

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Exploitation of cellular signaling and regulatory pathways by human cytomegalovirus

7 July 2018

1 reference

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Specific chromosome 1 breaks induced by human cytomegalovirus.

7 July 2018

1 reference

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A cytomegalovirus-encoded mitochondria-localized inhibitor of apoptosis structurally unrelated to Bcl-2.

7 July 2018

1 reference

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Human cytomegalovirus 86-kilodalton IE2 protein blocks cell cycle progression in G(1).

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

7 July 2018

Mdm2: the ups and downs

1 reference

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Effects of human cytomegalovirus major immediate-early proteins in controlling the cell cycle and inhibiting apoptosis: studies with ts13 cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Functions of the MDM2 oncoprotein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Cellular gene expression altered by human cytomegalovirus: global monitoring with oligonucleotide arrays

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Extracellular signal-regulated kinase activity is sustained early during human cytomegalovirus infection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Defective growth correlates with reduced accumulation of a viral DNA replication protein after low-multiplicity infection by a human cytomegalovirus ie1 mutant

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Identification of a viral kinase that phosphorylates specific E2Fs and pocket proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Human cytomegalovirus IE2 86-kilodalton protein binds p53 but does not abrogate G1 checkpoint function.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-kappaB promoters

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

The major immediate-early proteins IE1 and IE2 of human cytomegalovirus colocalize with and disrupt PML-associated nuclear bodies at very early times in infected permissive cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

p53, the cellular gatekeeper for growth and division

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Human cytomegalovirus infection inhibits G1/S transition.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

The human cytomegalovirus IE1-72 protein interacts with the cellular p107 protein and relieves p107-mediated transcriptional repression of an E2F-responsive promoter.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Human cytomegalovirus immediate-early protein IE2 tethers a transcriptional repression domain to p53.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Human cytomegalovirus elevates levels of the cellular protein p53 in infected fibroblasts

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Stimulation of E2F1/DP1 transcriptional activity by MDM2 oncoprotein

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Human cytomegalovirus IE1 and IE2 proteins block apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Interaction of the 72-kilodalton human cytomegalovirus IE1 gene product with E2F1 coincides with E2F-dependent activation of dihydrofolate reductase transcription

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Cytomegalovirus infection induces high levels of cyclins, phosphorylated Rb, and p53, leading to cell cycle arrest

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Human cytomegalovirus immediate-early two protein region involved in negative regulation of the major immediate-early promoter

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Transactivation of a human cytomegalovirus early promoter by gene products from the immediate-early gene IE2 and augmentation by IE1: mutational analysis of the viral proteins

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Cyclin A repression in quiescent cells is associated with chromatin remodeling of its promoter and requires Brahma/SNF2alpha

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

MDM2 transformation in the absence of p53 and abrogation of the p107 G1 cell-cycle arrest.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Productive infection of human endometrial stromal cells by human cytomegalovirus

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1440454

Potential role of human cytomegalovirus and p53 interaction in coronary restenosis

27 October 2018

1 reference

12 December 2020

Interaction of human cytomegalovirus with p53: possible role in coronary restenosis

1 reference

12 December 2020

p53 expression in CMV-infected cells: association with the alternative expression of the p53 transactivated genes p21/WAF1 and MDM2

1 reference

12 December 2020

RB regulates the stability and the apoptotic function of p53 via MDM2

1 reference

12 December 2020

The role of MKK1/2 kinase activity in human cytomegalovirus infection

1 reference

12 December 2020

10.1128/JVI.80.8.3833-3843.2006

Identifiers

DOI

1 reference

2 August 2017

1 reference

2 August 2017

1 reference