Nef: agent of cell subversion (Q34552824)

3 August 2017

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title

Nef: agent of cell subversion (English)

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3 August 2017

1

Vivek K Arora

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3 August 2017

author name string

Brenda L Fredericksen

series ordinal

2

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3 August 2017

J Victor Garcia

series ordinal

3

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3 August 2017

publication date

1 February 2002

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3 August 2017

published in

Microbes and Infection

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3 August 2017

volume

4

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3 August 2017

issue

2

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3 August 2017

page(s)

189-199

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HIV-1 regulatory/accessory genes: keys to unraveling viral and host cell biology

3 August 2017

cites work

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7 January 2021

Importance of the nef gene for maintenance of high virus loads and for development of AIDS

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Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients

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Brief report: absence of intact nef sequences in a long-term survivor with nonprogressive HIV-1 infection

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7 January 2021

Immunologic and virologic status after 14 to 18 years of infection with an attenuated strain of HIV-1. A report from the Sydney Blood Bank Cohort

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7 January 2021

HIV induces thymus depletion in vivo

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7 January 2021

Requirement of human immunodeficiency virus type 1 nef for in vivo replication and pathogenicity

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7 January 2021

Separation of human immunodeficiency virus type 1 replication from nef-mediated pathogenesis in the human thymus

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7 January 2021

Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice

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7 January 2021

Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene

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7 January 2021

Severe immunodeficiency associated with a human immunodeficiency virus 1 NEF/3'-long terminal repeat transgene

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7 January 2021

Effects of mutations within the 3' orf open reading frame region of human T-cell lymphotropic virus type III (HTLV-III/LAV) on replication and cytopathogenicity

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7 January 2021

Nef protein of human immunodeficiency virus type 1: evidence against its role as a transcriptional inhibitor

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7 January 2021

Lack of a negative influence on viral growth by the nef gene of human immunodeficiency virus type 1.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef from human immunodeficiency virus type 1(F12) inhibits viral production and infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The decreased replicative capacity of simian immunodeficiency virus SIVmac239Delta(nef) is manifest in cultures of immature dendritic cellsand T cells

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The role of Nef in the replication cycle of the human and simian immunodeficiency viruses

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Kinetics of expression of multiply spliced RNA in early human immunodeficiency virus type 1 infection of lymphocytes and monocytes

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Selective transcription and modulation of resting T cell activity by preintegrated HIV DNA.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

A conserved domain and membrane targeting of Nef from HIV and SIV are required for association with a cellular serine kinase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef induces CD4 endocytosis: requirement for a critical dileucine motif in the membrane-proximal CD4 cytoplasmic domain

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Cellular distribution of HIV type 1 Nef protein: identification of domains in Nef required for association with membrane and detergent-insoluble cellular matrix

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Myristoylation-enhanced binding of the HIV-1 Nef protein to T cell skeletal matrix.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Analysis of human immunodeficiency virus type 1 nef gene sequences present in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Genetic and functional diversity of human immunodeficiency virus type 1 subtype B Nef primary isolates

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Simian and human immunodeficiency virus Nef proteins use different surfaces to downregulate class I major histocompatibility complex antigen expression

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Analysis of the SH3-binding region of HIV-1 nef: partial functional defects introduced by mutations in the polyproline helix and the hydrophobic pocket

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Structural and functional correlates between HIV-1 and SIV Nef isolates

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef interacts with the mu subunit of clathrin adaptor complexes and reveals a cryptic sorting signal in MHC I molecules

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

CD4 down-regulation by nef alleles isolated from human immunodeficiency virus type 1-infected individuals

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef-mediated clathrin-coated pit formation

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Distinct trafficking pathways mediate Nef-induced and clathrin-dependent major histocompatibility complex class I down-regulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Human immunodeficiency virus type 1 Nef-induced CD4 cell surface downregulation is inhibited by ikarugamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Inhibition of Nef- and phorbol ester-induced CD4 degradation by macrolide antibiotics.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Human immunodeficiency virus type 1 Nef-induced down-modulation of CD4 is due to rapid internalization and degradation of surface CD4.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The HIV-1 Nef protein acts as a connector with sorting pathways in the Golgi and at the plasma membrane

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Myristoylation-dependent binding of HIV-1 Nef to CD4.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef-CD4 physical interaction sensed with the yeast two-hybrid system

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The CD4 determinant for downregulation by HIV-1 Nef directly binds to Nef. Mapping of the Nef binding surface by NMR.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Direct in vitro binding of full-length human immunodeficiency virus type 1 Nef protein to CD4 cytoplasmic domain

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef-induced CD4 and major histocompatibility complex class I (MHC-I) down-regulation are governed by distinct determinants: N-terminal alpha helix and proline repeat of Nef selectively regulate MHC-I trafficking

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

A dileucine motif in HIV-1 Nef is essential for sorting into clathrin-coated pits and for downregulation of CD4

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Two elements target SIV Nef to the AP-2 clathrin adaptor complex, but only one is required for the induction of CD4 endocytosis

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Mechanism of Nef-induced CD4 endocytosis: Nef connects CD4 with the mu chain of adaptor complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Subunit interactions in the clathrin-coated vesicle vacuolar (H(+))-ATPase complex

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Interactions between HIV1 Nef and vacuolar ATPase facilitate the internalization of CD4

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Negative factor from SIV binds to the catalytic subunit of the V-ATPase to internalize CD4 and to increase viral infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Two independent regions of HIV-1 Nef are required for connection with the endocytic pathway through binding to the mu 1 chain of AP1 complex.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef-induced CD4 degradation: a diacidic-based motif in Nef functions as a lysosomal targeting signal through the binding of beta-COP in endosomes

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef-induced CD4 downregulation: a diacidic sequence in human immunodeficiency virus type 1 Nef does not function as a protein sorting motif through direct binding to beta-COP.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Putative immunodominant human immunodeficiency virus-specific CD8(+) T-cell responses cannot be predicted by major histocompatibility complex class I haplotype

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The dileucine-based sorting motif in HIV-1 Nef is not required for down-regulation of class I MHC.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

HIV-1 Nef blocks transport of MHC class I molecules to the cell surface via a PI 3-kinase-dependent pathway

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

PACS-1 defines a novel gene family of cytosolic sorting proteins required for trans-Golgi network localization

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Association of simian immunodeficiency virus Nef with the T-cell receptor (TCR) zeta chain leads to TCR down-modulation

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Mechanism for down-regulation of CD28 by Nef.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Down-modulation of the costimulatory molecule, CD28, is a conserved activity of multiple SIV Nefs and is dependent on histidine 196 of Nef.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Separable functions of Nef disrupt two aspects of T cell receptor machinery: CD4 expression and CD3 signaling

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

HIV-1 Nef increases T cell activation in a stimulus-dependent manner

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The Nef protein of HIV-1 associates with rafts and primes T cells for activation

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Identification of the Nef-associated kinase as p21-activated kinase 2

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Lentivirus Nef specifically activates Pak2.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

A Nck-Pak1 signaling module is required for T-cell receptor-mediated activation of NFAT, but not of JNK

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Activation of NFAT-dependent gene expression by Nef: conservation among divergent Nef alleles, dependence on SH3 binding and membrane association, and cooperation with protein kinase C-theta

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

SH3-Domain binding function of HIV-1 Nef is required for association with a PAK-related kinase

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor zeta chain

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Interactions of HIV-1 NEF with cellular signal transducing proteins

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Rack1 binds HIV-1 Nef and can act as a Nef-protein kinase C adaptor

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

SH3-mediated Hck tyrosine kinase activation and fibroblast transformation by the Nef protein of HIV-1.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

HIV-1 Nef promotes survival of myeloid cells by a Stat3-dependent pathway.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Expression of the human immunodeficiency virus type 1 (HIV-1) nef gene during HIV-1 production increases progeny particle infectivity independently of gp160 or viral entry.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Dissociation of the CD4 downregulation and viral infectivity enhancement functions of human immunodeficiency virus type 1 Nef.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef stimulates human immunodeficiency virus type 1 proviral DNA synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Human immunodeficiency virus type 1 particles pseudotyped with envelope proteins that fuse at low pH no longer require Nef for optimal infectivity

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Pseudotyping human immunodeficiency virus type 1 (HIV-1) by the glycoprotein of vesicular stomatitis virus targets HIV-1 entry to an endocytic pathway and suppresses both the requirement for Nef and the sensitivity to cyclosporin A.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Infectivity enhancement by HIV-1 Nef is dependent on the pathway of virus entry: implications for HIV-based gene transfer systems

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Human immunodeficiency virus type 1 Nef functions at the level of virus entry by enhancing cytoplasmic delivery of virions

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Nef enhances human immunodeficiency virus type 1 infectivity resulting from intervirion fusion: evidence supporting a role for Nef at the virion envelope

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Stable expression of human immunodeficiency virus type 1 Nef confers resistance against Fas-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Apoptosis enhancement by the HIV-1 Nef protein.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

The human immunodeficiency virus type 1 nef gene can to a large extent replace simian immunodeficiency virus nef in vivo.

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Simian immunodeficiency virus containing mutations in N-terminal tyrosine residues and in the PxxP motif in Nef replicates efficiently in rhesus macaques

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Association of simian immunodeficiency virus Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Activation of PAK by HIV and SIV Nef: importance for AIDS in rhesus macaques

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

Mutation of a conserved residue (D123) required for oligomerization of human immunodeficiency virus type 1 Nef protein abolishes interaction with human thioesterase and results in impairment of Nef biological functions

1 reference

https://api.crossref.org/works/10.1016%2FS1286-4579%2801%2901527-1

7 January 2021

10.1016/S1286-4579(01)01527-1

Identifiers

DOI

1 reference

3 August 2017

1 reference