Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer. (Q34554818)

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28 December 2019

review article

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title

Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer (English)

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28 December 2019

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3

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28 December 2019

author name string

King A

series ordinal

1

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28 December 2019

Selak MA

series ordinal

2

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28 December 2019

language of work or name

English

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publication date

1 August 2006

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28 December 2019

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28 December 2019

volume

25

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28 December 2019

page(s)

4675-4682

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28 December 2019

issue

34

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209594

28 December 2019

exact match

0 references

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A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas

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Disruption of oxygen homeostasis underlies congenital Chuvash polycythemia

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Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma

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On the association of succinate dehydrogenase mutations with hereditary paraganglioma

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Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma

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An Alu-mediated partial SDHC deletion causes familial and sporadic paraganglioma

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Clinical presentation and penetrance of pheochromocytoma/paraganglioma syndromes.

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Mitochondrial succinate is instrumental for HIF1alpha nuclear translocation in SDHA-mutant fibroblasts under normoxic conditions.

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Identification of novel small molecule inhibitors of hypoxia-inducible factor-1 that differentially block hypoxia-inducible factor-1 activity and hypoxia-inducible factor-1alpha induction in response to hypoxic stress and growth factors

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Evolving concepts in pheochromocytoma and paraganglioma

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SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology.

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Hereditary paraganglioma/pheochromocytoma and inherited succinate dehydrogenase deficiency

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Why do cancers have high aerobic glycolysis?

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JunD reduces tumor angiogenesis by protecting cells from oxidative stress

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The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of complex II in the mitochondrial respiratory chain and activates the hypoxia pathway

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Functional consequences of a SDHB gene mutation in an apparently sporadic pheochromocytoma

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The HIF pathway as a therapeutic target

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von Hippel-Lindau protein mutants linked to type 2C VHL disease preserve the ability to downregulate HIF.

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HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

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A mutation in succinate dehydrogenase cytochrome b causes oxidative stress and ageing in nematodes.

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Role of VHL gene mutation in human cancer

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Small molecule blockade of transcriptional coactivation of the hypoxia-inducible factor pathway

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Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer

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7 January 2021

Biallelic inactivation of fumarate hydratase (FH) occurs in nonsyndromic uterine leiomyomas but is rare in other tumors

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Mitochondrial dysfunction in cancer

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Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations

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Mutations in SDHC cause autosomal dominant paraganglioma, type 3.

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Mutations of the SDHB and SDHD genes

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Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer

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Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma

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Distinct expression profile in fumarate-hydratase-deficient uterine fibroids.

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Novel mutations in FH and expansion of the spectrum of phenotypes expressed in families with hereditary leiomyomatosis and renal cell cancer

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Glycobiology and cancer: meeting summary and future diections

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Architecture of succinate dehydrogenase and reactive oxygen species generation

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Cancer metabolism: facts, fantasy, and fiction

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Identifiers

DOI

10.1038/SJ.ONC.1209594

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16892081%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

28 December 2019

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