Akt-dependent transformation: there is more to growth than just surviving (Q36313173)

13 August 2017

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title

Akt-dependent transformation: there is more to growth than just surviving (English)

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13 August 2017

2

Craig B Thompson

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13 August 2017

David R Plas

1

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PubMed ID

16288290

13 August 2017

language of work or name

English

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publication date

1 November 2005

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13 August 2017

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13 August 2017

24

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13 August 2017

7435-7442

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13 August 2017

50

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https://scigraph.springernature.com/pub.10.1038/sj.onc.1209097

13 August 2017

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cites work

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Isoform-specific regulation of insulin-dependent glucose uptake by Akt/protein kinase B.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Stimulation of sugar uptake in cultured fibroblasts by epidermal growth factor (EGF) and EGF-binding arginine esterase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Chronic myeloid leukaemia: an investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

The identification of ATP-citrate lyase as a protein kinase B (Akt) substrate in primary adipocytes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Stimulation of glycolysis and amino acid uptake in NRK-49F cells by transforming growth factor beta and epidermal growth factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Advances in protein kinase B signalling: AKTion on multiple fronts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Cell cycle and death control: long live Forkheads

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

The glucose dependence of Akt-transformed cells can be reversed by pharmacologic activation of fatty acid beta-oxidation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Insulin increases the association of Akt-2 with Glut4-containing vesicles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Mammalian TOR: a homeostatic ATP sensor

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Convergence of peroxisome proliferator-activated receptor gamma and Foxo1 signaling pathways

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Akt stimulates aerobic glycolysis in cancer cells

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Severe diabetes, age-dependent loss of adipose tissue, and mild growth deficiency in mice lacking Akt2/PKB beta

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Role of oxidative phosphorylation in Bax toxicity.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Upstream and downstream of mTOR

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Amino acid transporters: roles in amino acid sensing and signalling in animal cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

TSC2 mediates cellular energy response to control cell growth and survival

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

DAF-16 target genes that control C. elegans life-span and metabolism.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Mammalian SIRT1 represses forkhead transcription factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Akt activation promotes degradation of tuberin and FOXO3a via the proteasome

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Akt regulates growth by directly phosphorylating Tsc2

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

IL-7 enhances the survival and maintains the size of naive T cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Insulin signalling and the regulation of glucose and lipid metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Rheb promotes cell growth as a component of the insulin/TOR signalling network

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

TOR, a central controller of cell growth

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Regulation of mTOR and cell growth in response to energy stress by REDD1.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

FOXO4 is acetylated upon peroxide stress and deacetylated by the longevity protein hSir2(SIRT1)

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Growth factors can influence cell growth and survival through effects on glucose metabolism

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Amino acid availability regulates p70 S6 kinase and multiple translation factors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Translational induction of the c-myc oncogene via activation of the FRAP/TOR signalling pathway

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

LKB1 is the upstream kinase in the AMP-activated protein kinase cascade

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Akt2 phosphorylates Synip to regulate docking and fusion of GLUT4-containing vesicles

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Suppression of FOXO1 activity by FHL2 through SIRT1-mediated deacetylation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1209097

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1209097

1 reference

13 August 2017

1 reference

PubMed ID

16288290