HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery (Q34564346)

3 August 2017

title

HTS by NMR of combinatorial libraries: a fragment-based approach to ligand discovery (English)

1 reference

3 August 2017

Bainan Wu

1

1 reference

3 August 2017

Ziming Zhang

2

1 reference

3 August 2017

Roberta Noberini

3

1 reference

3 August 2017

Elisa Barile

4

1 reference

3 August 2017

Marc Giulianotti

5

1 reference

3 August 2017

Clemencia Pinilla

6

1 reference

3 August 2017

Richard A Houghten

7

1 reference

3 August 2017

Elena B Pasquale

8

1 reference

3 August 2017

Maurizio Pellecchia

9

1 reference

3 August 2017

publication date

1 January 2013

1 reference

3 August 2017

published in

Chemistry and Biology

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3 August 2017

volume

20

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3 August 2017

issue

1

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3 August 2017

page(s)

19-33

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Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor

3 August 2017

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PEGylation potentiates the effectiveness of an antagonistic peptide that targets the EphB4 receptor with nanomolar affinity

7 July 2018

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Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes

7 July 2018

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GM-CSF production allows the identification of immunoprevalent antigens recognized by human CD4+ T cells following smallpox vaccination

7 July 2018

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A disalicylic acid-furanyl derivative inhibits ephrin binding to a subset of Eph receptors

7 July 2018

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Lithocholic acid is an Eph-ephrin ligand interfering with Eph-kinase activation

7 July 2018

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The rise of fragment-based drug discovery

7 July 2018

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Identification of candidate IgG biomarkers for Alzheimer's disease via combinatorial library screening

7 July 2018

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Small molecule functional analogs of peptides that inhibit lambda site-specific recombination and bind Holliday junctions

7 July 2018

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The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

7 July 2018

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7 July 2018

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Identification of two novel, potent, low-liability antinociceptive compounds from the direct in vivo screening of a large mixture-based combinatorial library

7 July 2018

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Eph receptors and ephrins in cancer: bidirectional signalling and beyond

7 July 2018

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New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

7 July 2018

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Small-molecule pan-IAP antagonists: a patent review

7 July 2018

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Combining positional scanning peptide libraries, HLA-DR transfectants and bioinformatics to dissect the epitope spectrum of HLA class II cross-restricted CD4+ T cell clones.

7 July 2018

1 reference

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Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding Promiscuity

7 July 2018

1 reference

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Structural Plasticity of Eph Receptor A4 Facilitates Cross-Class Ephrin Signaling

7 July 2018

1 reference

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NMR methods in fragment screening: theory and a comparison with other biophysical techniques

7 July 2018

1 reference

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Development of Peptidomimetics Targeting IAPs

7 July 2018

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Fragment-based ligand discovery

7 July 2018

1 reference

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Perspectives on NMR in drug discovery: a technique comes of age

7 July 2018

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Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors

7 July 2018

1 reference

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Crystal Structure and NMR Binding Reveal That Two Small Molecule Antagonists Target the High Affinity Ephrin-binding Channel of the EphA4 Receptor

7 July 2018

1 reference

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Recent developments in fragment-based drug discovery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Using specificity to strategically target proteases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Fragment approaches in structure-based drug discovery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Eph-ephrin bidirectional signaling in physiology and disease

7 July 2018

1 reference

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Strategies for the use of mixture-based synthetic combinatorial libraries: scaffold ranking, direct testing in vivo, and enhanced deconvolution by computational methods

7 July 2018

1 reference

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Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors

7 July 2018

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A decade of fragment-based drug design: strategic advances and lessons learned

7 July 2018

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Methods for mapping protease specificity

7 July 2018

1 reference

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Screening in a spirit haunted world

7 July 2018

1 reference

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Identification of cross-reactive peptides using combinatorial libraries circumvents tolerance against Her-2/neu-immunodominant epitope

7 July 2018

1 reference

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High-throughput assays for promiscuous inhibitors.

7 July 2018

1 reference

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Solution nuclear magnetic resonance spectroscopy techniques for probing intermolecular interactions

7 July 2018

1 reference

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Control of protein-protein interactions: structure-based discovery of low molecular weight inhibitors of the interactions between Pin1 WW domain and phosphopeptides

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Eph receptor signalling casts a wide net on cell behaviour

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

NMR-based techniques in the hit identification and optimisation processes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Beta-actin is required for mitochondria clustering and ROS generation in TNF-induced, caspase-independent cell death

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Mechanism of XIAP-mediated inhibition of caspase-9

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

7 July 2018

NMR in drug discovery

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Structural biology. Controlling the caspases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Utility of the secreted placental alkaline phosphatase reporter enzyme

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Fluorescence polarization: an analytical tool for immunoassay and drug discovery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Exploring immunological specificity using synthetic peptide combinatorial libraries.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Selective ligands for the mu, delta, and kappa opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library

7 July 2018

1 reference

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Discovering high-affinity ligands for proteins: SAR by NMR

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

The use of positional scanning synthetic peptide combinatorial libraries for the rapid determination of opioid receptor ligands

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Investigation of antigen-antibody interactions using a soluble, non-support-bound synthetic decapeptide library composed of four trillion (4 x 10(12) sequences

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Rapid identification of high affinity peptide ligands using positional scanning synthetic peptide combinatorial libraries

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

HTS promiscuity analyses for accelerating decision making

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

SMAC mimetics sensitize nonsteroidal anti-inflammatory drug-induced apoptosis by promoting caspase-3-mediated cytochrome c release

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

A high-throughput screen for aggregation-based inhibition in a large compound library

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Interpreting steep dose-response curves in early inhibitor discovery

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Targeting the EphA4 receptor in the nervous system with biologically active peptides

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

An ephrin mimetic peptide that selectively targets the EphA2 receptor

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Localizing the NADP+ binding site on the MurB enzyme by NMR.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Fluorescence anisotropy applied to biomolecular interactions.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Conformational selection, dynamic restriction and the hydrophobic effect coupled to stabilization of the BIR3 domain of the human X-linked inhibitor of apoptosis protein by the tetrapeptide AVPI

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3966493

Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23352136

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Structural and biophysical characterization of XIAP BIR3 G306E mutant: insights in protein dynamics and application for fragment-based drug design

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23352136

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Alkaline phosphatase fusions of ligands or receptors as in situ probes for staining of cells, tissues, and embryos

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23352136

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CHEMBIOL.2012.10.015

1 reference

3 August 2017

1 reference

3 August 2017

1 reference