Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179. (Q34568528)

3 August 2017

title

Triterpenoid CDDO-Me blocks the NF-kappaB pathway by direct inhibition of IKKbeta on Cys-179. (English)

1 reference

3 August 2017

0 references

Rehan Ahmad

1

1 reference

3 August 2017

Deepak Raina

2

1 reference

3 August 2017

Colin Meyer

3

1 reference

3 August 2017

Surender Kharbanda

4

1 reference

3 August 2017

Donald Kufe

5

1 reference

3 August 2017

language of work or name

English

0 references

publication date

24 September 2006

1 reference

Journal of Biological Chemistry

3 August 2017

published in

1 reference

3 August 2017

volume

281

1 reference

3 August 2017

issue

47

1 reference

3 August 2017

page(s)

35764-35769

1 reference

Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia

3 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

BRCA1 transcriptionally regulates damaged DNA binding protein (DDB2) in the DNA repair response following UV-irradiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

c-Jun NH2-terminal kinase-mediated up-regulation of death receptor 5 contributes to induction of apoptosis by the novel synthetic triterpenoid methyl-2-cyano-3,12-dioxooleana-1, 9-dien-28-oate in human lung cancer cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Synthetic triterpenoids cooperate with tumor necrosis factor-related apoptosis-inducing ligand to induce apoptosis of breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

2-Cyano-3,12-dioxooleana-1,9-dien-28-imidazolide (CDDO-Im) directly targets mitochondrial glutathione to induce apoptosis in pancreatic cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

NF-kappaB in cancer: from innocent bystander to major culprit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

21 January 2018

Signaling to NF-kappaB

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Design, synthesis, and biological evaluation of biotin conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid for the isolation of the protein targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Ubiquitin signalling in the NF-kappaB pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Inhibition of transcription factor NF-kappaB signaling proteins IKKbeta and p65 through specific cysteine residues by epoxyquinone A monomer: correlation with its anti-cancer cell growth activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Binding of manumycin A inhibits IkappaB kinase beta activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

A synthetic triterpenoid, CDDO-Me, inhibits IkappaBalpha kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor kappaB-regulated gene products in human leukemic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

Reactive oxygen special (ROS), troublemakers between nuclear factor-kB (NF-kB) and c-Jun NH2-terminal kinase (JNK)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M607160200

21 January 2018

Identifiers

DOI

10.1074/JBC.M607160200

1 reference

3 August 2017

1 reference