The B7-CD28 superfamily (Q34575331)

3 August 2017

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title

The B7-CD28 superfamily (English)

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3 August 2017

2

Gordon J Freeman

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3 August 2017

1

Arlene H Sharpe

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3 August 2017

1 February 2002

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Nature Reviews Immunology

3 August 2017

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3 August 2017

2

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3 August 2017

2

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3 August 2017

116-126

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A Theory of Self-Nonself Discrimination: Paralysis and induction involve the recognition of one and two determinants on an antigen, respectively

3 August 2017

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A two-step, two-signal model for the primary activation of precursor helper T cells

31 March 2020

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Antigen presentation by chemically modified splenocytes induces antigen-specific T cell unresponsiveness in vitro and in vivo

31 March 2020

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T cell activation determined by T cell receptor number and tunable thresholds.

31 March 2020

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Induction of T-cell anergy by altered T-cell-receptor ligand on live antigen-presenting cells

31 March 2020

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CTLA-4 and T cell activation

31 March 2020

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Complexities of CD28/B7: CTLA-4 costimulatory pathways in autoimmunity and transplantation

31 March 2020

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CD28, CTLA-4 and their ligands: who does what and to whom?

31 March 2020

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CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy

31 March 2020

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ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28

31 March 2020

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Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro

31 March 2020

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B7h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha

31 March 2020

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Cutting edge: identification of GL50, a novel B7-like protein that functionally binds to ICOS receptor

31 March 2020

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T-cell co-stimulation through B7RP-1 and ICOS

31 March 2020

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LICOS, a primordial costimulatory ligand?

31 March 2020

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Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death

31 March 2020

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Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation

31 March 2020

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B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion

31 March 2020

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PD-L2 is a second ligand for PD-1 and inhibits T cell activation

31 March 2020

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B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells

31 March 2020

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Structure, expression, and T cell costimulatory activity of the murine homologue of the human B lymphocyte activation antigen B7

31 March 2020

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Cloning of B7-2: a CTLA-4 counter-receptor that costimulates human T cell proliferation

31 March 2020

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Murine B7-2, an alternative CTLA4 counter-receptor that costimulates T cell proliferation and interleukin 2 production

31 March 2020

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B70 antigen is a second ligand for CTLA-4 and CD28.

31 March 2020

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A new member of the immunoglobulin superfamily--CTLA-4

31 March 2020

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CTLA-4 is a second receptor for the B cell activation antigen B7

31 March 2020

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Complementarity determining region 1 (CDR1)- and CDR3-analogous regions in CTLA-4 and CD28 determine the binding to B7-1.

31 March 2020

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Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes

31 March 2020

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Intracellular trafficking of CTLA-4 and focal localization towards sites of TCR engagement

31 March 2020

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Comparative analysis of B7-1 and B7-2 costimulatory ligands: expression and function

31 March 2020

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The role of B7 co-stimulation in activation and differentiation of CD4+ and CD8+ T cells

31 March 2020

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CD28/B7 system of T cell costimulation

31 March 2020

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From TCR Engagement to T Cell Activation

31 March 2020

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CD28 activation pathway regulates the production of multiple T-cell-derived lymphokines/cytokines

31 March 2020

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Differential T cell costimulatory requirements in CD28-deficient mice

31 March 2020

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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL.

31 March 2020

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CTLA-4 can function as a negative regulator of T cell activation

31 March 2020

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CTLA-4 ligation blocks CD28-dependent T cell activation

31 March 2020

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CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation

31 March 2020

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Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

31 March 2020

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

31 March 2020

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B7-1 or B7-2 is required to produce the lymphoproliferative phenotype in mice lacking cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)

31 March 2020

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Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.

31 March 2020

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Enhancement of antitumor immunity by CTLA-4 blockade

31 March 2020

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The T cell activation molecule H4 and the CD28-like molecule ICOS are identical

31 March 2020

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Identification and characterization of rat AILIM/ICOS, a novel T-cell costimulatory molecule, related to the CD28/CTLA4 family

31 March 2020

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Induction, binding specificity and function of human ICOS

31 March 2020

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31 March 2020

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Molecular cloning and characterization of murine ICOS and identification of B7h as ICOS ligand

31 March 2020

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Mouse inducible costimulatory molecule (ICOS) expression is enhanced by CD28 costimulation and regulates differentiation of CD4+ T cells

31 March 2020

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Characterization of human inducible costimulator ligand expression and function

31 March 2020

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Inducible costimulator protein (ICOS) controls T helper cell subset polarization after virus and parasite infection

31 March 2020

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ICOS is critical for CD40-mediated antibody class switching

31 March 2020

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ICOS co-stimulatory receptor is essential for T-cell activation and function

31 March 2020

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Cutting edge: critical role of inducible costimulator in germinal center reactions

31 March 2020

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ICOS is essential for effective T-helper-cell responses

31 March 2020

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Characterization of a new human B7-related protein: B7RP-1 is the ligand to the co-stimulatory protein ICOS

31 March 2020

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Tumor necrosis factor-alpha regulates the expression of inducible costimulator receptor ligand on CD34(+) progenitor cells during differentiation into antigen presenting cells.

31 March 2020

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ICOS costimulation requires IL-2 and can be prevented by CTLA-4 engagement

31 March 2020

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Inducible costimulator regulates Th2-mediated inflammation, but not Th2 differentiation, in a model of allergic airway disease

31 March 2020

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ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses

31 March 2020

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Costimulation of memory T-cells by ICOS: a potential therapeutic target for autoimmunity?

31 March 2020

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ICOS costimulation: is it the key to selective immunotherapy?

31 March 2020

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Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection

31 March 2020

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Association of B7-1 co-stimulation with the development of graft arterial disease. Studies using mice lacking B7-1, B7-2, or B7-1/B7-2.

31 March 2020

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CD28-B7-mediated T cell costimulation in chronic cardiac allograft rejection: differential role of B7-1 in initiation versus progression of graft arteriosclerosis

31 March 2020

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B7-1 and B7-2 have overlapping, critical roles in immunoglobulin class switching and germinal center formation

31 March 2020

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The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE.

31 March 2020

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ICOS ligand costimulation is required for T-cell encephalitogenicity.

31 March 2020

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Studies in B7-deficient mice reveal a critical role for B7 costimulation in both induction and effector phases of experimental autoimmune encephalomyelitis

31 March 2020

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Experimental autoimmune meningitis: a novel neurological disease in CD28-deficient mice.

31 March 2020

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An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease.

31 March 2020

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Enhancement of CD8+ T cell responses by ICOS/B7h costimulation

31 March 2020

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Structure and chromosomal localization of the human PD-1 gene (PDCD1)

31 March 2020

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Activation-induced expression of human programmed death-1 gene in T-lymphocytes

31 March 2020

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Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes

31 March 2020

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Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-CD8-) thymocytes

31 March 2020

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Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice

31 March 2020

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Laser capture microdissection-based expression profiling identifies PD1-ligand as a target of the nude locus gene product

31 March 2020

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Immunological studies on PD-1 deficient mice: implication of PD-1 as a negative regulator for B cell responses

31 March 2020

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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor

31 March 2020

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Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice

31 March 2020

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PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2

31 March 2020

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CD4+CD25high regulatory cells in human peripheral blood

31 March 2020

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B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function

31 March 2020

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PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine

31 March 2020

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CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A

31 March 2020

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B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production

31 March 2020

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Structural organization and mammary-specific expression of the butyrophilin gene

31 March 2020

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The cluster of BTN genes in the extended major histocompatibility complex

31 March 2020

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BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse.

31 March 2020

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Extending the B7 (CD80) gene family

31 March 2020

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A review and proposed nomenclature for major proteins of the milk-fat globule membrane

31 March 2020

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Butyrophilin is expressed in mammary epithelial cells from a single-sized messenger RNA as a type I membrane glycoprotein

31 March 2020

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Carboxy-terminal cytoplasmic domain of mouse butyrophilin specifically associates with a 150-kDa protein of mammary epithelial cells and milk fat globule membrane

31 March 2020

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Milk fat globule glycoproteins in human milk and in gastric aspirates of mother's milk-fed preterm infants

31 March 2020

1 reference

Butyrophilin, a milk protein, modulates the encephalitogenic T cell response to myelin oligodendrocyte glycoprotein in experimental autoimmune encephalomyelitis.

31 March 2020

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A genomic view of immunology.

31 March 2020

1 reference

Structure and dimerization of a soluble form of B7-1

31 March 2020

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Structural basis for co-stimulation by the human CTLA-4/B7-2 complex

31 March 2020

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Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses

31 March 2020

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Targeting the B7/CD28:CTLA-4 costimulatory system in CNS autoimmune disease

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI727

1 reference

3 August 2017

1 reference

PubMed ID

11910893