TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. (Q34579440)

3 August 2017

TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. (English)

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3 August 2017

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Robert B. Nussenblatt

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object named as

Robert B Nussenblatt

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3 August 2017

Ahjoku Amadi-Obi

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3 August 2017

Cheng-Rong Yu

2

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3 August 2017

Xuebin Liu

3

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3 August 2017

Rashid M Mahdi

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3 August 2017

Grace Levy Clarke

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3 August 2017

Igal Gery

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3 August 2017

Yun Sang Lee

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3 August 2017

Charles E Egwuagu

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3 August 2017

language of work or name

English

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publication date

13 May 2007

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3 August 2017

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3 August 2017

13

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3 August 2017

711-718

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3 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/nm1585

3 August 2017

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cites work

STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient mice

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Cell proliferation and STAT6 pathways are negatively regulated in T cells by STAT1 and suppressors of cytokine signaling.

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Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance

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A role for IL-27 in early regulation of Th1 differentiation

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IL-27 limits IL-2 production during Th1 differentiation.

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Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism.

21 January 2018

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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

21 January 2018

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New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6

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TGF-beta, a 'double agent' in the immune pathology war

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Th17: an effector CD4 T cell lineage with regulatory T cell ties

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Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel.

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Treatment of noninfectious intermediate and posterior uveitis with the humanized anti-Tac mAb: a phase I/II clinical trial

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Involvement of CCR5 in the passage of Th1-type cells across the blood-retina barrier in experimental autoimmune uveitis

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Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis.

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IL-17 plays an important role in the development of experimental autoimmune encephalomyelitis

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Suppression of immune induction of collagen-induced arthritis in IL-17-deficient mice

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IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist

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Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

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Induction of suppressors of cytokine signaling (SOCS) in the retina during experimental autoimmune uveitis (EAU): potential neuroprotective role of SOCS proteins.

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IL-17 family cytokines and the expanding diversity of effector T cell lineages

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Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells

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Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4.

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Biology of recently discovered cytokines: discerning the pro- and anti-inflammatory properties of interleukin-27

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Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

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7 January 2021

Helper T cell differentiation enters a new era: le roi est mort; vive le roi!

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7 January 2021

IL-27 subunits and its receptor (WSX-1) mRNAs are markedly up-regulated in inflammatory cells in the CNS during experimental autoimmune encephalomyelitis.

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7 January 2021

Production of IL-27 and other IL-12 family cytokines by microglia and their subpopulations.

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7 January 2021

Cytokine profile in Behçet's disease patients. Relationship with disease activity

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7 January 2021

Cytokines and chemokines in neuro-Behçet's disease compared to multiple sclerosis and other neurological diseases

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Ocular involvement in Behçet's disease: first 5-year-results for visual development after treatment with interferon alfa-2a

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Effects of interferon alpha treatment on the clinical course of refractory Behçet's disease: an open study

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7 January 2021

Humanized anti-interleukin-2 (IL-2) receptor alpha therapy: long-term results in uveitis patients and preliminary safety and activity data for establishing parameters for subcutaneous administration

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7 January 2021

SOCS5 mRNA levels in peripheral blood mononuclear cells (PBMC): a potential bio-marker for monitoring response of uveitis patients to Daclizumab therapy

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7 January 2021

Identifiers

DOI

10.1038/NM1585

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3 August 2017

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