The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme. (Q34597385)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25224009%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

title

The clinical candidate VT-1161 is a highly potent inhibitor of Candida albicans CYP51 but fails to bind the human enzyme (English)

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16 February 2020

1 reference

1

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16 February 2020

Josie E. Parker

3

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16 February 2020

author name string

C M Hull

2

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16 February 2020

E P Garvey

4

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16 February 2020

W J Hoekstra

5

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16 February 2020

W R Moore

6

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16 February 2020

R J Schotzinger

7

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16 February 2020

D E Kelly

8

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S L Kelly

9

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16 February 2020

language of work or name

English

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publication date

15 September 2014

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Antimicrobial Agents and Chemotherapy

16 February 2020

published in

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16 February 2020

volume

58

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issue

12

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16 February 2020

page(s)

7121-7127

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Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals

16 February 2020

cites work

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Azole affinity of sterol 14α-demethylase (CYP51) enzymes from Candida albicans and Homo sapiens

7 July 2018

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Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B.

7 July 2018

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A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14alpha-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B.

7 July 2018

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The antifungal drug voriconazole is an efficient inhibitor of brain cholesterol 24S-hydroxylase in vitro and in vivo

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Expression and functional characterization of cytochrome P450 26A1, a retinoic acid hydroxylase

7 July 2018

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Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates

7 July 2018

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A Candida albicans petite mutant strain with uncoupled oxidative phosphorylation overexpresses MDR1 and has diminished susceptibility to fluconazole and voriconazole

7 July 2018

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7 July 2018

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7 July 2018

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The utility of in vitro cytochrome P450 inhibition data in the prediction of drug-drug interactions

7 July 2018

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7 July 2018

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ASSESSING PREGNANCY RISKS OF AZOLE ANTIFUNGALS USING A HIGH THROUGHPUT AROMATASE INHIBITION ASSAY

7 July 2018

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Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2, CYP2C9, CYP2C19, CYP2D6, rCYP2D6, and CYP3A4 in vitro using a single point IC(50).

7 July 2018

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The N-terminal membrane domain of yeast NADPH-cytochrome P450 (CYP) oxidoreductase is not required for catalytic activity in sterol biosynthesis or in reconstitution of CYP activity

7 July 2018

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7 July 2018

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Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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26 October 2018

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26 October 2018

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26 October 2018

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26 October 2018

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26 October 2018

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Effect of voriconazole and other azole antifungal agents on CYP3A activity and metabolism of tacrolimus in human liver microsomes

26 October 2018

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12 December 2020

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12 December 2020

Design and optimization of highly-selective fungal CYP51 inhibitors

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12 December 2020

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12 December 2020

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Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients

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12 December 2020

Identifiers

DOI

10.1128/AAC.03707-14

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25224009%20AND%20SRC:MED&resulttype=core&format=json

16 February 2020

1 reference

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16 February 2020

PubMed publication ID

25224009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25224009%20AND%20SRC:MED&resulttype=core&format=json