5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction (Q34605000)

3 August 2017

5-fluorouracil activation of p53 involves an MDM2-ribosomal protein interaction (English)

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3 August 2017

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Xiao-Xin Sun

1

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3 August 2017

Mu-Shui Dai

series ordinal

2

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3 August 2017

Hua Lu

series ordinal

3

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3 August 2017

language of work or name

English

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publication date

22 January 2007

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Journal of Biological Chemistry

3 August 2017

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3 August 2017

282

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3 August 2017

11

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3 August 2017

8052-8059

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5-Fluorouracil: mechanisms of action and clinical strategies

3 August 2017

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https://api.crossref.org/works/10.1074%2FJBC.M610621200

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

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Regulation of p53 stability and function in HCT116 colon cancer cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610621200

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610621200

High-frequency microsatellite instability predicts better chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV sporadic colorectal cancer after palliative bowel resection

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610621200

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610621200

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Regulation of p53 stability by Mdm2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610621200

The p53-mdm2 autoregulatory feedback loop: a paradigm for the regulation of growth control by p53?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610621200

Decision making by p53: life, death and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

21 January 2018

Surfing the p53 network

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https://api.crossref.org/works/10.1074%2FJBC.M610621200

Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Ribosomal protein L23 activates p53 by inhibiting MDM2 function in response to ribosomal perturbation but not to translation inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Inhibition of MDM2-mediated p53 ubiquitination and degradation by ribosomal protein L5

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Regulation of the MDM2-p53 pathway by ribosomal protein L11 involves a post-ubiquitination mechanism

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610621200

Regulation of HDM2 activity by the ribosomal protein L11

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M610621200

Inhibition of HDM2 and activation of p53 by ribosomal protein L23

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Ribosomal Protein L11 Negatively Regulates Oncoprotein MDM2 and Mediates a p53-Dependent Ribosomal-Stress Checkpoint Pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Inhibition by uridine but not thymidine of p53-dependent intestinal apoptosis initiated by 5-fluorouracil: evidence for the involvement of RNA perturbation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Does the ribosome translate cancer?

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Evidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Stress signals utilize multiple pathways to stabilize p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

PML regulates p53 stability by sequestering Mdm2 to the nucleolus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

p53 ubiquitination: Mdm2 and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Balance of Yin and Yang: ubiquitylation-mediated regulation of p53 and c-Myc

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Aberrant cell cycle inhibition pattern in human colon carcinoma cell lines after exposure to 5-fluorouracil

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Effect of 5-fluorouracil on G1 phase cell cycle regulation in oral cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M610621200

21 January 2018

Identifiers

DOI

10.1074/JBC.M610621200

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3 August 2017

1 reference