Regulation of p53 stability and function in HCT116 colon cancer cells (Q40609042)

22 September 2017

Regulation of p53 stability and function in HCT116 colon cancer cells (English)

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22 September 2017

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Matthias D Kaeser

1

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22 September 2017

Stephanie Pebernard

series ordinal

2

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22 September 2017

Richard D Iggo

series ordinal

3

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22 September 2017

language of work or name

English

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publication date

9 December 2003

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Journal of Biological Chemistry

22 September 2017

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22 September 2017

279

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22 September 2017

9

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22 September 2017

7598-7605

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22 September 2017

Surfing the p53 network

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

p53 has a direct apoptogenic role at the mitochondria

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Regulation of p53 stability by Mdm2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Mdm2 promotes the rapid degradation of p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Polyubiquitination of p53 by a ubiquitin ligase activity of p300.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

DNA damage activates p53 through a phosphorylation-acetylation cascade

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Regulation of p53 function and stability by phosphorylation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Phosphorylation site interdependence of human p53 post-translational modifications in response to stress

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Cell type- and promoter-specific roles of Ser18 phosphorylation in regulating p53 responses

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Mutation of mouse p53 Ser23 and the response to DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Disruption of p53 in human cancer cells alters the responses to therapeutic agents

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Increased apoptosis induction by 121F mutant p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

A system for stable expression of short interfering RNAs in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

PUMA induces the rapid apoptosis of colorectal cancer cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

PUMA, a novel proapoptotic gene, is induced by p53

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

PUMA mediates the apoptotic response to p53 in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Hypophosphorylation of Mdm2 augments p53 stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

A transactivation-deficient mouse model provides insights into Trp53 regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Role of BAX in the apoptotic response to anticancer agents

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Ferredoxin reductase affects p53-dependent, 5-fluorouracil-induced apoptosis in colorectal cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

The Chk2 tumor suppressor is not required for p53 responses in human cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Tolerance of high levels of wild-type p53 in transformed epithelial cells dependent on auto-regulation by mdm-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Methylation silencing and mutations of the p14ARF and p16INK4a genes in colon cancer

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

COP9 signalosome-specific phosphorylation targets p53 to degradation by the ubiquitin system

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

Induction of an interferon response by RNAi vectors in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M311732200

Acetylation of p53 activates transcription through recruitment of coactivators/histone acetyltransferases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

An immunochemical analysis of the human nuclear phosphoprotein p53. New monoclonal antibodies and epitope mapping using recombinant p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M311732200

21 January 2018

Identifiers

DOI

10.1074/JBC.M311732200

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22 September 2017

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