Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds. (Q34616168)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100004%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

review article

1 reference

title

Inhibitors of indoleamine 2,3-dioxygenase: a review of novel patented lead compounds (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100004%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

0 references

Raimondo De Cristofaro

series ordinal

3

1 reference

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17 January 2020

Sergio Rutella

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100004%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

2

Silvio Danese

1 reference

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17 January 2020

author name string

Tiziana Di Pucchio

series ordinal

1

1 reference

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17 January 2020

language of work or name

English

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publication date

1 February 2010

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Expert Opinion on Therapeutic Patents

17 January 2020

published in

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17 January 2020

volume

20

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17 January 2020

issue

2

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17 January 2020

page(s)

229-250

1 reference

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IDO expression by dendritic cells: tolerance and tryptophan catabolism

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21 January 2018

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Marrying immunotherapy with chemotherapy: why say IDO?

21 January 2018

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Highlights at the gate of tryptophan catabolism: a review on the mechanisms of activation and regulation of indoleamine 2,3-dioxygenase (IDO), a novel target in cancer disease

21 January 2018

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Manipulation of indoleamine 2,3 dioxygenase; a novel therapeutic target for treatment of diseases

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Crystal structure of human indoleamine 2,3-dioxygenase: catalytic mechanism of O2 incorporation by a heme-containing dioxygenase

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Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific

21 January 2018

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1-Methyl-DL-tryptophan, beta-(3-benzofuranyl)-DL-alanine (the oxygen analog of tryptophan), and beta-[3-benzo(b)thienyl]-DL-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase

21 January 2018

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Targeting the mechanisms of tumoral immune tolerance with small-molecule inhibitors.

21 January 2018

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Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy.

21 January 2018

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Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses

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Toxicology and pharmacokinetics of 1-methyl-d-tryptophan: absence of toxicity due to saturating absorption.

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IRF-7 is the master regulator of type-I interferon-dependent immune responses

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Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells

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IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

The role of L-tryptophan transport in L-tryptophan degradation by indoleamine 2,3-dioxygenase in human placental explants

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Twelve immunotherapy drugs that could cure cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Inhibition of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by beta-carboline and indole derivatives

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Enzyme kinetic and spectroscopic studies of inhibitor and effector interactions with indoleamine 2,3-dioxygenase. 1. Norharman and 4-phenylimidazole binding to the enzyme as inhibitors and heme ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Structure-activity study of brassinin derivatives as indoleamine 2,3-dioxygenase inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

A key in vivo antitumor mechanism of action of natural product-based brassinins is inhibition of indoleamine 2,3-dioxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

(-)-Epigallocatechin gallate suppresses indoleamine 2,3-dioxygenase expression in murine dendritic cells: evidences for the COX-2 and STAT1 as potential targets.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Novel N-hydroxyguanidine derivatives as anticancer and antiviral agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Biomimetic synthesis of the IDO inhibitors exiguamine A and B.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Exiguamine A, an indoleamine-2,3-dioxygenase (IDO) inhibitor isolated from the marine sponge Neopetrosia exigua

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Aspirin down-regulates tryptophan degradation in stimulated human peripheral blood mononuclear cells in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Immunomodulatory effects of Turkish propolis: changes in neopterin release and tryptophan degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

In vitro effects of two extracts and two pure alkaloid preparations of Uncaria tomentosa on peripheral blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

St. John's wort (Hypericum perforatum) counteracts cytokine-induced tryptophan catabolism in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Cacao extracts suppress tryptophan degradation of mitogen-stimulated peripheral blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Curcumin suppresses the induction of indoleamine 2,3-dioxygenase by blocking the Janus-activated kinase-protein kinase Cdelta-STAT1 signaling pathway in interferon-gamma-stimulated murine dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

The immunoregulatory role of IDO-producing human dendritic cells revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Expression of indoleamine 2,3-dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Cutting edge: CpG oligonucleotides induce splenic CD19+ dendritic cells to acquire potent indoleamine 2,3-dioxygenase-dependent T cell regulatory functions via IFN Type 1 signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

T cells, B cells, and polarized immune response in the pathogenesis of fibrosis and systemic sclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

IDO: a double-edged sword for T(H)1/T(H)2 regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

The kynurenines are associated with oxidative stress, inflammation and the prevalence of cardiovascular disease in patients with end-stage renal disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Indoleamine 2,3-dioxygenase activity and L-tryptophan transport in human breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543770903512974

10.1517/13543770903512974

21 January 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20100004%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference