Genotoxicity of pyrrolizidine alkaloids (Q34616318)

30 June 2019

review article

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title

Genotoxicity of pyrrolizidine alkaloids (English)

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30 June 2019

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pyrrolizidine alkaloid

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2

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30 June 2019

author name string

Tao Chen

series ordinal

1

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30 June 2019

Peter P Fu

series ordinal

3

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30 June 2019

language of work or name

English

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publication date

1 April 2010

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30 June 2019

Journal of Applied Toxicology

published in

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30 June 2019

volume

30

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30 June 2019

issue

3

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30 June 2019

page(s)

183-196

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30 June 2019

The mutagenic activity of the pyrrolizidine alkaloid heliotrine in Drosophila melanogaster. II. Chromosome rearrangements.

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Toxicity and metabolism of pyrrolizidine alkaloids

21 January 2018

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Naturally occuring mutagens

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Primary liver tumours in rats following feeding with alkaloids of Senecio jacobaea

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Some toxic properties of a carcinogenic pyrrolizidine alkaloid, petasitenine

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Evaluation studies on the in vitro rat hepatocyte micronucleus assay.

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Application of the in vitro rat hepatocyte micronucleus assay in genetic toxicology testing

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The ability of bifunctional and monofunctional pyrrole compounds to induce sister-chromatid exchange (SCE) in human lymphocytes and mutations in Salmonella typhimurium

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Primary carcinoma of the liver in Ethiopia. A study of 38 cases proved at post-mortem examination

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Pyrrolizidine alkaloids in human diet

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Malignant neoplasms in rats fed lasiocarpine

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Micronuclei in adult and foetal mice exposed in vivo to heliotrine, urethane, monocrotaline and benzidine

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Induction of micronuclei by alkaloids extracted from Senecio brasiliensis and stored for 23 years

21 January 2018

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Pancreatic islet cell and other tumours induced in rats by heliotrine- a mono-ester pyrrolizidine alkaloid; the effects of additional treatment with nicotinamide

21 January 2018

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Progression of liver lesions produced in rats by temporary treatment with pyrrolizidine (senecio) alkaloids, and the effects of betaine and high casein diet

21 January 2018

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Senecio alkaloids; primary liver tumours in rats as a result of treatment with (1) a mixture of alkaloids from S. jacobaea Lin.; (2) retrorsine; (3) isatidine

21 January 2018

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Mutagenic responses of tansy ragwort (Senecio jacobaea) plant, pyrrolizidine alkaloids and metabolites in goat milk with the Salmonella/mammalian-microsome mutagenicity test

21 January 2018

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Hepatocellular carcinoma in infancy and childhood in Ibadan, Western Nigeria

21 January 2018

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Evaluation of the single cell gel electrophoresis assay with human hepatoma (Hep G2) cells

21 January 2018

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Milk transfer of pyrrolizidine alkoloids in cattle

21 January 2018

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12 December 2020

Pyrrolizidine alkaloid plants, metabolism and toxicity

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12 December 2020

Hepatotoxicity associated with pyrrolizidine alkaloid (Crotalaria spp) ingestion in a horse on Easter Island

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12 December 2020

Fukinotoxin, a new pyrrolizidine alkaloid from Petasites japonicus

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12 December 2020

Comparative DNA cross-linking by activated pyrrolizidine alkaloids

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12 December 2020

Reductive Activation of a Hydroxylamine Hemiacetal Derivative of Dehydromonocrotaline: The First Reductively Activated Pyrrolizidine Alkaloid Capable of Cross-Linking DNA

1 reference

12 December 2020

Tansy ragwort poisoning in a horse in southern Ontario

1 reference

12 December 2020

Clinical and analytical aspects of pyrrolizidine poisoning caused by South African traditional medicines.

1 reference

12 December 2020

Use of repair-deficient strains of escherichia coli and liver microsomes to detect and characterise DNA damage caused by the pyrrolizidine alkaloids heliotrine and monocrotaline

1 reference

12 December 2020

Medicinal plants in China containing pyrrolizidine alkaloids

1 reference

12 December 2020

Dehydroretronecine-induced rhabdomyosarcomas in rats

1 reference

12 December 2020

Metabolic activation of the tumorigenic pyrrolizidine alkaloid, riddelliine, leading to DNA adduct formation in vivo

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12 December 2020

Honey from plants containing pyrrolizidine alkaloids: a potential threat to health.

1 reference

12 December 2020

NTP technical report on the toxicity studies of Riddelliine (CAS No. 23246-96-0) Administered by Gavage to F344 Rats and B6C3F1 Mice.

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12 December 2020

Human Liver Microsomal Metabolism and DNA Adduct Formation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine

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12 December 2020

Carcinogenic activity of coltsfoot, Tussilago farfara l

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12 December 2020

Correlation of DNA adduct formation and riddelliine-induced liver tumorigenesis in F344 rats and B6C3F(1) mice

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12 December 2020

Toxicology and carcinogenesis studies of riddelliine (CAS No. 23246-96-0) in F344/N rats and B6C3F1 mice (gavage studies).

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12 December 2020

Toxicity and carcinogenicity of riddelliine in rats and mice

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12 December 2020

Identification of DNA adducts derived from riddelliine, a carcinogenic pyrrolizidine alkaloid

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12 December 2020

Veno-occlusive disease of liver with nonportal type of cirrhosis, occurring in Jamaica

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12 December 2020

Guinea pig and rat hepatic microsomal metabolism of monocrotaline

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12 December 2020

Mutagenic activity of the alkaloid heliotrine in Drosophila.

1 reference

12 December 2020

Chemical-specific alterations in ras, p53, and beta-catenin genes in hemangiosarcomas from B6C3F1 mice exposed to o-nitrotoluene or riddelliine for 2 years

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12 December 2020

Mutagenicity of pyrrolizidine alkaloids in the Salmonella typhimurium/mammalian microsome system

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12 December 2020

Genotoxic action of an aqueous extract of Heliotropium curassavicum var. argentinum

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12 December 2020

The clastogenic potential in vitro of pyrrolizidine alkaloids employing hepatocyte metabolism

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12 December 2020

Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine

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12 December 2020

Pyrrolizidine alkaloid composition of three Chinese medicinal herbs, Eupatorium cannabinum, E. japonicum and Crotalaria assamica

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12 December 2020

Pyrrolizidine alkaloids--genotoxicity, metabolism enzymes, metabolic activation, and mechanisms

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12 December 2020

Metabolic formation of DHP-derived DNA adducts from a representative otonecine type pyrrolizidine alkaloid clivorine and the extract of Ligularia hodgsonnii hook.

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12 December 2020

Mutations induced by the carcinogenic pyrrolizidine alkaloid riddelliine in the liver cII gene of transgenic big blue rats.

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12 December 2020

DNA cross-linking by dehydromonocrotaline lacks apparent base sequence preference

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12 December 2020

Differential mutagenicity of riddelliine in liver endothelial and parenchymal cells of transgenic big blue rats

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12 December 2020

Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid

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12 December 2020

Mutagenicity of comfrey (Symphytum Officinale) in rat liver

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12 December 2020

Metabolic activation of the tumorigenic pyrrolizidine alkaloid, monocrotaline, leading to DNA adduct formation in vivo

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12 December 2020

Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, lasiocarpine.

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12 December 2020

Structure/activity relationships of the genotoxic potencies of sixteen pyrrolizidine alkaloids assayed for the induction of somatic mutation and recombination in wing cells of Drosophila melanogaster.

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12 December 2020

Metabolic activation of the tumorigenic pyrrolizidine alkaloid, retrorsine, leading to DNA adduct formation in vivo

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12 December 2020

Analysis of gene expression changes in relation to toxicity and tumorigenesis in the livers of Big Blue transgenic rats fed comfrey (Symphytum officinale)

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12 December 2020

Formation of DHP-derived DNA adducts in vivo from dietary supplements and chinese herbal plant extracts containing carcinogenic pyrrolizidine alkaloids.

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12 December 2020

Neoplastic Transformation in Tissues of Rats Exposed to Monocrotaline or Dehydroretronecine23

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12 December 2020

Comparison of gene expression profiles altered by comfrey and riddelliine in rat liver

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12 December 2020

Gene expression changes induced by the tumorigenic pyrrolizidine alkaloid riddelliine in liver of Big Blue rats

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12 December 2020

Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine

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12 December 2020

Metabolic activation of retronecine and retronecine N-oxide - formation of DHP-derived DNA adducts

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12 December 2020

Pyrrolizidine alkaloids in Crotalaria taxa from northern Australia: risk to grazing livestock.

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12 December 2020

Carcinogenic Activity of Petasitenine, a New Pyrrolizidine Alkaloid Isolated From Petasites japonicus Maxim2

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12 December 2020

DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: structure-activity relationships

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12 December 2020

Genotoxicity and morphological changes induced by the alkaloid monocrotaline, extracted from Crotalaria retusa, in a model of glial cells

1 reference

12 December 2020

Hepatic veno-occlusive disease associated with comfrey ingestion

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12 December 2020

The in vivo erythrocyte micronucleus test: measurement at steady state increases assay efficiency and permits integration with toxicity studies

1 reference

12 December 2020

Sequence preferences of DNA interstrand cross-linking agents: dG-to-dG cross-linking at 5'-CG by structurally simplified analogues of mitomycin C

1 reference

12 December 2020

The effect of the pyrrolizidine alkaloid integerrimine on the chromosomes of mouse bone marrow cells

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12 December 2020

Comfrey herb tea and hepatic veno-occlusive disease

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12 December 2020

The role of flavin-containing monooxygenase in the N-oxidation of the pyrrolizidine alkaloid senecionine

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12 December 2020

Bioactivation and detoxication of the pyrrolizidine alkaloid senecionine by cytochrome P-450 enzymes in rat liver

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12 December 2020

The identification of pyrrolizidine alkaloid-containing plants--a study on 20 herbs of the Compositae family

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12 December 2020

Comfrey herb tea-induced hepatic veno-occlusive disease

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12 December 2020

Dehydroretronecine-Induced Skin Tumors in Mice23

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12 December 2020

Carcinogenic activity of Symphytum officinale

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12 December 2020

Induction of hepatic tumors in rats by senkirkine and symphytine

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12 December 2020

Somatic mutation induced by heliotrine in Drosophila.

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12 December 2020

Modulation of monocrotaline-induced hepatic genotoxicity in rats.

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12 December 2020

Veno-occlusive disease of the liver secondary to ingestion of comfrey

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12 December 2020

Crosslinking of DNA by dehydroretronecine, a metabolite of pyrrolizidine alkaloids

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12 December 2020

In vivo measurement of unscheduled DNA synthesis and S-phase synthesis as an indicator of hepatocarcinogenesis in rodents

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12 December 2020

Pyrrolizidine alkaloid poisoning of sheep in New South Wales

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12 December 2020

Mutagenicity of alkaloids in the Salmonella/microsome system

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12 December 2020

Toxicity of comfrey-pepsin preparations

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12 December 2020

Genotoxicity of the pyrrolizidine alkaloid jacobine in rats

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12 December 2020

Genotoxicity and cytotoxicity of selected pyrrolizidine alkaloids, a possible alkenal metabolite of the alkaloids, and related alkenals.

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12 December 2020

Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test

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12 December 2020

Herbal tea induced hepatic veno-occlusive disease: quantification of toxic alkaloid exposure in adults

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12 December 2020

Hepatic venocclusive disease associated with the consumption of pyrrolizidine-containing dietary supplements

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12 December 2020

Induction of SCEs by some pyrrolizidine alkaloids in V79 Chinese hamster cells co-cultured with chick embryo hepatocytes

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12 December 2020

In vivo covalent binding of retronecine-labelled [3H]seneciphylline and [3H]senecionine to DNA of rat liver, lung and kidney

1 reference

12 December 2020

Studies of medicinal plants of Sri Lanka. Part 14: Toxicity of some traditional medicinal herbs

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12 December 2020

The chronic toxicity of retrorsine, a pyrrolizidine alkaloid, in vervet monkeys

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12 December 2020

Toxicology and carcinogenic action of pyrrolizidine alkaloids

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12 December 2020

Islet cell tumors of the pancreas found in rats given pyrrolizidine alkaloids from Amsinckia intermedia Fisch and Mey and from Heliotropium supinum L

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12 December 2020

Ultrastructure of rat hepatocarcinoma due to retrorsine--a pyrrolizidine alkaloid.

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12 December 2020

Malignant tumors in rats given lasiocarpine

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12 December 2020

Laslocarpine-induced, transplantable squamous cell carcinoma of rat skin

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12 December 2020

Letter: Rectal prolapses in cattle associated with pyrrolizidine alkaloid poisoning

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12 December 2020

Brain and spinal cord tumors in rats treated with pyrrolizidine alkaloids.

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12 December 2020

Hepatotoxic Effects due to Pyrrolizidine AlkaloidN-Oxides

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12 December 2020

Preliminary findings of chromosomal studies on rats and humans with veno-occlusive disease

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12 December 2020

Histopathology of renal lipomatous tumors in rats treated with the "natural" products, pyrrolizidine alkaloids and , -unsaturated aldehydes

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12 December 2020

Pyrrolizidine alkaloid poisoning in a horse in New South Wales

1 reference

12 December 2020

Studies on orchidaceae alkaloids. XXIV. A pyrrolizidine alkaloid from Phalaenopsis cornu-cervi Rchb. f

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12 December 2020

Development of hepatic tumors in rats following ingestion of Senecio longilobus

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12 December 2020

Pyrrolizidine alkaloid poisoning in calves

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12 December 2020

The hepatotoxicity of some Ethiopian and East African plants, including some used in traditional medicines

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12 December 2020

The development of the hepatic megalocytosis of chronic pyrrolizidine alkaloid poisoning

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12 December 2020

An outbreak of hepatic veno-occlusive disease in north-western Afghanistan

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12 December 2020

An epidemic of veno-occlusive disease of liver in central India

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12 December 2020

Hepatic metabolism and pulmonary toxicity of monocrotaline using isolated perfused liver and lung

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12 December 2020

Toxic pyrrolizidine alkaloids in comfrey

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12 December 2020

Comfrey and liver damage

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12 December 2020

Hepatic veno-occlusive disease due to toxic alkaloid herbal tea

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12 December 2020

Pyrrolizidine alkaloids

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12 December 2020

Characterization of hepatic DNA damage induced in rats by the pyrrolizidine alkaloid monocrotaline

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12 December 2020

Mutagenic activity of the pyrrolizidine alkaloids seneciphylline and senkirkine in Drosophila and their transfer into rat milk

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12 December 2020

Cynoglossum officinale (hound's-tongue)--a cause of pyrrolizidine alkaloid poisoning in horses

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12 December 2020

Neoplasia and chronic disease associated with the prolonged administration of dehydroheliotridine to rats

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12 December 2020

Carcinogenic activity of Farfugium japonicum and Senecio cannabifolius.

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12 December 2020

Carcinogenicity of some pyrrolic pyrrolizidine alkaloid metabolites and analogues

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12 December 2020

Effect of calorie restriction on the fate of hyperplastic liver nodules induced by concurrent administration of lasiocarpine and thioacetamide

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12 December 2020

Pyrrolizidine alkaloid poisoning of horses

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12 December 2020

Chromosomal aberrations and mutation in cultured mammalian cells induced by pyrrolizidine alkaloids

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12 December 2020

CArcinogenic activity of clivorine, a pyrrolizidine alkaloid isolated from Ligularia dentata.

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12 December 2020

Pyrrolizidine alkaloids in honey from Echium plantagineum L

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12 December 2020

Studies on medicinal plants of Sri Lanka: Occurrence of pyrrolizidine alkaloids and hepatotoxic properties in some traditional medicinal herbs

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12 December 2020

Veno-occlusive liver disease due to intake of Senecio vulgaris tea

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12 December 2020

Pyrrolizidine alkaloid-induced DNA-protein cross-links

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12 December 2020

Clastogenic effect of extracts obtained from Crotalaria retusa L. and Crotalaria mucronata Desv. on mouse bone marrow cells

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12 December 2020

Medicinal plants in Europe containing pyrrolizidine alkaloids.

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12 December 2020

Reversible hepatic veno-occlusive disease in an infant after consumption of pyrrolizidine-containing herbal tea

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12 December 2020

Hepatotoxic pyrrolizidine alkaloids in the Mexican medicinal plant Packera candidissima (Asteraceae: Senecioneae).

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12 December 2020

Toxicity and carcinogenicity of riddelliine following 13 weeks of treatment to rats and mice

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12 December 2020

Pyrrolizidine alkaloids: their occurrence in honey from tansy ragwort (Senecio jacobaea L.)

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12 December 2020

Evaluation of the potential of riddelliine to induce unscheduled DNA synthesis, S-phase synthesis, or micronuclei following in vivo treatment with multiple doses

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12 December 2020

Characterization of monocrotaline pyrrole-induced DNA cross-linking in pulmonary artery endothelium

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12 December 2020

Recombinagenic activity of integerrimine, a pyrrolizidine alkaloid from Senecio brasiliensis, in somatic cells of Drosophila melanogaster.

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12 December 2020

Dehydromonocrotaline generates sequence-selective N-7 guanine alkylation and heat and alkali stable multiple fragment DNA crosslinks.

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12 December 2020

Pyrrolizidine alkaloids crosslink DNA with actin

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12 December 2020

Studies on Orchidaceae Alkaloids. XXIV. A Pyrrolizidine Alkaloid from Phalaenopsis cornu-cervi Rchb. f..

1 reference

12 April 2024

https://opencitations.net/index/api/v1/citations/10.3891/ACTA.CHEM.SCAND.25-0349

Identifiers

DOI

10.1002/JAT.1504

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30 June 2019

PMC publication ID

6376482

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30 June 2019

PubMed publication ID

20112250

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30 June 2019