Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer. (Q34621867)

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English	Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer.	scientific article

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22 January 2020

Aurora B kinase inhibitor AZD1152: determinants of action and ability to enhance chemotherapeutics effectiveness in pancreatic and colon cancer (English)

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22 January 2020

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Amalia Azzariti

1

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22 January 2020

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22 January 2020

Donatella Del Bufalo

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22 January 2020

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G Bocci

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22 January 2020

L Porcelli

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22 January 2020

A Fioravanti

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22 January 2020

P Sini

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22 January 2020

G M Simone

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22 January 2020

A E Quatrale

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22 January 2020

P Chiarappa

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22 January 2020

S Sebastian

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22 January 2020

M Del Tacca

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22 January 2020

A Paradiso

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22 January 2020

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8 February 2011

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22 January 2020

British Journal of Cancer

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22 January 2020

104

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22 January 2020

5

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22 January 2020

769-780

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22 January 2020

Clinical evaluation of AZD1152, an i.v. inhibitor of Aurora B kinase, in patients with solid malignant tumors.

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7 July 2018

Recent developments in palliative chemotherapy for locally advanced and metastatic pancreas cancer

1 reference

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7 July 2018

The selective Aurora B kinase inhibitor AZD1152 as a novel treatment for hepatocellular carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048212

7 July 2018

Analysis of Aurora B kinase in non-Hodgkin lymphoma

1 reference

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7 July 2018

Aurora A, centrosome structure, and the centrosome cycle

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7 July 2018

Clinical experience with aurora kinase inhibitors: a review

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7 July 2018

Pancreatic cancer: molecular pathogenesis and new therapeutic targets

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7 July 2018

AZD1152 rapidly and negatively affects the growth and survival of human acute myeloid leukemia cells in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048212

7 July 2018

The topoisomerase I poison CPT-11 enhances the effect of the aurora B kinase inhibitor AZD1152 both in vitro and in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048212

7 July 2018

Aurora B kinase regulates the postmitotic endoreduplication checkpoint via phosphorylation of the retinoblastoma protein at serine 780

1 reference

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7 July 2018

Systemic and targeted therapy for advanced colon cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048212

7 July 2018

Antiangiogenic and anticolorectal cancer effects of metronomic irinotecan chemotherapy alone and in combination with semaxinib

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7 July 2018

Prolonged versus standard gemcitabine infusion: translation of molecular pharmacology to new treatment strategy

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7 July 2018

Synergic antiproliferative and antiangiogenic effects of EGFR and mTor inhibitors on pancreatic cancer cells

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7 July 2018

Oxaliplatin retains HMGB1 intranuclearly and ameliorates collagen type II-induced arthritis

1 reference

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7 July 2018

The selective Aurora B kinase inhibitor AZD1152 is a potential new treatment for multiple myeloma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048212

7 July 2018

AZD1152, a selective inhibitor of Aurora B kinase, inhibits human tumor xenograft growth by inducing apoptosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048212

7 July 2018

The suppression of aurora-A/STK15/BTAK expression enhances chemosensitivity to docetaxel in human esophageal squamous cell carcinoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048212

7 July 2018

Aurora kinase inhibition downregulates NF-kappaB and sensitises tumour cells to chemotherapeutic agents

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048212

7 July 2018

Comparing Aurora A and Aurora B as molecular targets for growth inhibition of pancreatic cancer cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048212

7 July 2018

Prolonged exposure of colon cancer cells to the epidermal growth factor receptor inhibitor gefitinib (Iressa(TM)) and to the antiangiogenic agent ZD6474: Cytotoxic and biomolecular effects

1 reference

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7 July 2018

Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer.

1 reference

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7 July 2018

PHA-680632, a novel Aurora kinase inhibitor with potent antitumoral activity.

1 reference

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7 July 2018

Targeting Aurora kinases for the treatment of prostate cancer

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7 July 2018

Fluvastatin synergistically enhances the antiproliferative effect of gemcitabine in human pancreatic cancer MIAPaCa-2 cells.

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7 July 2018

RNA interference targeting aurora kinase a suppresses tumor growth and enhances the taxane chemosensitivity in human pancreatic cancer cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3048212

7 July 2018

Chfr is required for tumor suppression and Aurora A regulation

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7 July 2018

Platinums: extending their therapeutic spectrum

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7 July 2018

The schedule-dependent enhanced cytotoxic activity of 7-ethyl-10-hydroxy-camptothecin (SN-38) in combination with Gefitinib (Iressa, ZD1839).

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7 July 2018

The Aurora kinases: role in cell transformation and tumorigenesis

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7 July 2018

Gemcitabine potentiates cisplatin cytotoxicity and inhibits repair of cisplatin-DNA damage in ovarian cancer cell lines

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7 July 2018

Cell cycle-dependent expression and centrosome localization of a third human aurora/Ipl1-related protein kinase, AIK3

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7 July 2018

Preclinical evaluation of M30 and M65 ELISAs as biomarkers of drug induced tumor cell death and antitumor activity

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21 January 2018

The CHFR mitotic checkpoint protein delays cell cycle progression by excluding Cyclin B1 from the nucleus

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21 January 2018

Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152.

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21 January 2018

Aurora kinase B, epigenetic state of centromeric heterochromatin and chiasma resolution in oocytes

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21 January 2018

Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blasts

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21 January 2018

Characterization of sequence-dependent synergy between ZD1839 ("Iressa") and oxaliplatin.

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21 January 2018

Aurora-C: the youngest of "the three (Aurora kinase) tenors" of mitotic symphony.

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26 October 2018

Mitotic kinase expression and colorectal cancer progression

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https://pubmed.ncbi.nlm.nih.gov/21304529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/21304529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aurora kinase inhibitors in preclinical and clinical testing

1 reference

https://pubmed.ncbi.nlm.nih.gov/21304529

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1038/BJC.2011.21

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22 January 2020

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22 January 2020

PubMed publication ID

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22 January 2020

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