A phosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity (Q24319503)

positive regulation of Ras protein signal transduction

GOA release 2020-03-11

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GOA release 2020-03-11

3

Alma Burlingame

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author name string

Pablo Rodriguez-Viciana

1

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Juan Oses-Prieto

2

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Mike Fried

4

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Frank McCormick

Protein serine/threonine phosphatases: life, death, and sleeping.

5

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language of work or name

English

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publication date

21 April 2006

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published in

Molecular Cell

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volume

22

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issue

2

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page(s)

217-30

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cites work

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[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

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A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases

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The structural basis for 14-3-3:phosphopeptide binding specificity

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SUR-8, a conserved Ras-binding protein with leucine-rich repeats, positively regulates Ras-mediated signaling in C. elegans

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Ras and relatives--job sharing and networking keep an old family together

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Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites

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A generic protein purification method for protein complex characterization and proteome exploration

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Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1

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Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

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The RAF proteins take centre stage

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soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling

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Raf-1-associated Protein Phosphatase 2A as a Positive Regulator of Kinase Activation

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A PP2A regulatory subunit positively regulates Ras-mediated signaling during Caenorhabditis elegans vulval induction

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14-3-3 is not essential for Raf-1 function: identification of Raf-1 proteins that are biologically activated in a 14-3-3- and Ras-independent manner

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The RafC1 cysteine-rich domain contains multiple distinct regulatory epitopes which control Ras-dependent Raf activation

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14-3-3 antagonizes Ras-mediated Raf-1 recruitment to the plasma membrane to maintain signaling fidelity

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R-Ras3/M-Ras induces neuronal differentiation of PC12 cells through cell-type-specific activation of the mitogen-activated protein kinase cascade.

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Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate

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Distinct mechanisms determine the patterns of differential activation of H-Ras, N-Ras, K-Ras 4B, and M-Ras by receptors for growth factors or antigen.

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C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites

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