Chronic myeloid leukaemia as a model of disease evolution in human cancer (Q34631354)

3 August 2017

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title

Chronic myeloid leukaemia as a model of disease evolution in human cancer (English)

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3 August 2017

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Junia V Melo

1

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3 August 2017

David J Barnes

series ordinal

2

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3 August 2017

language of work or name

English

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publication date

1 June 2007

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3 August 2017

Nature Reviews Cancer

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3 August 2017

7

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3 August 2017

6

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3 August 2017

441-453

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https://scigraph.springernature.com/pub.10.1038/nrc2147

3 August 2017

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cites work

Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining

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Tyrosine kinase activity and transformation potency of bcr-abl oncogene products.

31 March 2020

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In vitro transformation of immature hematopoietic cells by the P210 BCR/ABL oncogene product of the Philadelphia chromosome

31 March 2020

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Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome

31 March 2020

1 reference

Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells

31 March 2020

1 reference

Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

31 March 2020

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Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

31 March 2020

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Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

31 March 2020

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Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

31 March 2020

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Subcellular localization of Bcr, Abl, and Bcr-Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation

31 March 2020

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The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization

31 March 2020

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The biology of CML blast crisis

31 March 2020

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IL-3 dependent regulation of Bcl-xL gene expression by STAT5 in a bone marrow derived cell line

31 March 2020

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Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL

31 March 2020

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Transcriptional regulation of the cyclin D1 promoter by STAT5: its involvement in cytokine-dependent growth of hematopoietic cells

31 March 2020

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STAT5-Dependent CyclinD1 and Bcl-xL expression in Bcr-Abl-transformed cells

31 March 2020

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BCR-ABL activates pathways mediating cytokine independence and protection against apoptosis in murine hematopoietic cells in a dose-dependent manner

31 March 2020

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Biological effects induced by variable levels of BCR-ABL protein in the pluripotent hematopoietic cell line UT-7.

31 March 2020

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Dose-dependent effects of Bcr-Abl in cell line models of different stages of chronic myeloid leukemia

31 March 2020

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Bcr-Abl expression levels determine the rate of development of resistance to imatinib mesylate in chronic myeloid leukemia

31 March 2020

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The amount of BCR-ABL fusion transcripts detected by the real-time quantitative polymerase chain reaction method in patients with Philadelphia chromosome positive chronic myeloid leukemia correlates with the disease stage

31 March 2020

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Stem cell origin of cancer and differentiation therapy

31 March 2020

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BCR-ABL suppresses C/EBPalpha expression through inhibitory action of hnRNP E2.

31 March 2020

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Absence of the transcription factor CCAAT enhancer binding protein alpha results in loss of myeloid identity in bcr/abl-induced malignancy.

31 March 2020

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Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

31 March 2020

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Mutations of the myeloid transcription factor CEBPA are not associated with the blast crisis of chronic myeloid leukaemia.

31 March 2020

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Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBPalpha.

31 March 2020

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Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells

31 March 2020

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Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein alpha-deficient mice

31 March 2020

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Cooperation of BCR-ABL and AML1/MDS1/EVI1 in blocking myeloid differentiation and rapid induction of an acute myelogenous leukemia

31 March 2020

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A murine model of CML blast crisis induced by cooperation between BCR/ABL and NUP98/HOXA9

31 March 2020

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Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia

31 March 2020

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NUP98 gene rearrangements and the clonal evolution of chronic myelogenous leukemia

31 March 2020

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Expression of the NUP98/HOXA9 fusion transcript in the blast crisis of Philadelphia chromosome-positive chronic myelogenous leukaemia with t(7;11)(p15;p15).

31 March 2020

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Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

31 March 2020

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A role for Wnt signalling in self-renewal of haematopoietic stem cells

31 March 2020

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Wnt proteins are lipid-modified and can act as stem cell growth factors

31 March 2020

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A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation

31 March 2020

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Blasts from the past: new lessons in stem cell biology from chronic myelogenous leukemia

31 March 2020

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Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma

31 March 2020

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Wnt-signalling pathway in ovarian epithelial tumours: increased expression of beta-catenin and GSK3beta

31 March 2020

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Activation of the Wnt pathway in non small cell lung cancer: evidence of dishevelled overexpression

31 March 2020

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Cytogenetic and molecular genetic evolution of chronic myeloid leukemia.

31 March 2020

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Investigation on the role of the ATM gene in chronic myeloid leukaemia

31 March 2020

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BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint

31 March 2020

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Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase.

31 March 2020

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Chk1 and Chk2 kinases in checkpoint control and cancer

31 March 2020

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An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication

31 March 2020

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A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

31 March 2020

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Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada

31 March 2020

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Down-regulation of BRCA1 in BCR-ABL-expressing hematopoietic cells

31 March 2020

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BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage

31 March 2020

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ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks.

31 March 2020

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DNA double-strand breaks: signaling, repair and the cancer connection

31 March 2020

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BCR-ABL down-regulates the DNA repair protein DNA-PKcs

31 March 2020

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DNA double strand break repair in human bladder cancer is error prone and involves microhomology-associated end-joining

31 March 2020

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BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance

31 March 2020

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BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks

31 March 2020

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BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells

31 March 2020

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BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

31 March 2020

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A recurrent mutation in PALB2 in Finnish cancer families.

31 March 2020

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Molecular mechanism of nucleotide excision repair.

31 March 2020

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p210 BCR/ABL kinase regulates nucleotide excision repair (NER) and resistance to UV radiation

31 March 2020

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The BCR-ABL oncoprotein potentially interacts with the xeroderma pigmentosum group B protein

31 March 2020

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Mammalian DNA nucleotide excision repair reconstituted with purified protein components.

31 March 2020

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Evaluation of xeroderma pigmentosum XPA, XPC, XPD, XPF, XPB, XPG and DDB2 genes in familial early-onset lung cancer predisposition

31 March 2020

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Multiple mutations and cancer

31 March 2020

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Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase.

31 March 2020

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Mutator phenotype of BCR--ABL transfected Ba/F3 cell lines and its association with enhanced expression of DNA polymerase beta

31 March 2020

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Genome maintenance mechanisms for preventing cancer

31 March 2020

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Telomere reduction in human colorectal carcinoma and with ageing

31 March 2020

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A critical role for telomeres in suppressing and facilitating carcinogenesis

31 March 2020

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Telomere shortening correlates with prognostic score at diagnosis and proceeds rapidly during progression of chronic myeloid leukemia

31 March 2020

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Specific association of human telomerase activity with immortal cells and cancer

31 March 2020

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hTERT, the catalytic component of telomerase, is downregulated in the haematopoietic stem cells of patients with chronic myeloid leukaemia

31 March 2020

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Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase

31 March 2020

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The tumor suppressor PP2A is functionally inactivated in blast crisis CML through the inhibitory activity of the BCR/ABL-regulated SET protein

31 March 2020

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Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

31 March 2020

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Managing the patient with chronic myeloid leukemia through and after allogeneic stem cell transplantation

31 March 2020

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Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

31 March 2020

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Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

31 March 2020

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Frequency of major molecular responses to imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia

31 March 2020

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Gene expression changes associated with progression and response in chronic myeloid leukemia

31 March 2020

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Characterization of stage progression in chronic myeloid leukemia by DNA microarray with purified hematopoietic stem cells

31 March 2020

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P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members

31 March 2020

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Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl

31 March 2020

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Chronic myelogenous leukemia molecular signature.

31 March 2020

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A gene-expression signature as a predictor of survival in breast cancer

31 March 2020

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Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer

31 March 2020

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Diagnostics. Amid debate, gene-based cancer test approved.

31 March 2020

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A genetic signature can predict prognosis and response to therapy in breast cancer: Oncotype DX.

31 March 2020

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Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML.

31 March 2020

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Reappraisal of the clinical significance of CD7 expression in association with cytogenetics in de novo acute myeloid leukaemia

31 March 2020

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Clinical significance of phenotypic features of blasts in patients with myelodysplastic syndrome

31 March 2020

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Identification and in vitro expansion of CD4+ and CD8+ T cells specific for human neutrophil elastase

31 March 2020

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Gene expression profiling reveals a massive, aneuploidy-dependent transcriptional deregulation and distinct differences between lymph node-negative and lymph node-positive colon carcinomas

31 March 2020

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The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability

31 March 2020

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The life and death of DNA-PK.

31 March 2020

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Considering the cancer consequences of altered DNA polymerase function

31 March 2020

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Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia

31 March 2020

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p53 in chronic myelogenous leukemia in acute phase

31 March 2020

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BCR/ABL activates mdm2 mRNA translation via the La antigen

31 March 2020

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Alterations of P53 and RB genes and the evolution of the accelerated phase of chronic myeloid leukemia

31 March 2020

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Involvement of the cyclin-dependent kinase-4 inhibitor (CDKN2) gene in the pathogenesis of lymphoid blast crisis of chronic myelogenous leukaemia.

31 March 2020

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Genomic p16 abnormalities in the progression of chronic myeloid leukemia into blast crisis

31 March 2020

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A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

31 March 2020

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

31 March 2020

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

31 March 2020

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The INK4A/ARF locus and its two gene products

31 March 2020

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The regulation of INK4/ARF in cancer and aging

31 March 2020

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

31 March 2020

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Frequent methylation of p16INK4A and p14ARF genes implicated in the evolution of chronic myeloid leukaemia from its chronic to accelerated phase

31 March 2020

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Chronic myeloid leukemia blast crisis arises from progenitors.

31 March 2020

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Primitive, quiescent, Philadelphia-positive stem cells from patients with chronic myeloid leukemia are insensitive to STI571 in vitro

31 March 2020

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Imatinib mesylate (STI571) inhibits growth of primitive malignant progenitors in chronic myelogenous leukemia through reversal of abnormally increased proliferation

31 March 2020

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Dasatinib (BMS-354825) targets an earlier progenitor population than imatinib in primary CML but does not eliminate the quiescent fraction

31 March 2020

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Kinase domain mutants of Bcr-Abl exhibit altered transformation potency, kinase activity, and substrate utilization, irrespective of sensitivity to imatinib

31 March 2020

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Dynamics of chronic myeloid leukaemia.

31 March 2020

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Long-term outcome of treatment of anemia in MDS with erythropoietin and G-CSF.

31 March 2020

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Dysregulated expression of the major telomerase components in leukaemic stem cells.

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2147

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Dimensions Publication ID

3 August 2017

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