Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation (Q34635166)

3 August 2017

Translational repression of MCL-1 couples stress-induced eIF2 alpha phosphorylation to mitochondrial apoptosis initiation (English)

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3 August 2017

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Ralph M Fritsch

1

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3 August 2017

Günter Schneider

2

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3 August 2017

Dieter Saur

3

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3 August 2017

Melanie Scheibel

4

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3 August 2017

Roland M Schmid

5

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3 August 2017

language of work or name

English

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publication date

6 June 2007

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Journal of Biological Chemistry

3 August 2017

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3 August 2017

282

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3 August 2017

22551-22562

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3 August 2017

31

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The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice

3 August 2017

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Activation of GCN2 in UV-irradiated cells inhibits translation

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Translational control in stress and apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Regulated translation initiation controls stress-induced gene expression in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Phosphorylation of the alpha subunit of eukaryotic initiation factor 2 is required for activation of NF-kappaB in response to diverse cellular stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Cytoprotection by pre-emptive conditional phosphorylation of translation initiation factor 2

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Perk is essential for translational regulation and cell survival during the unfolded protein response

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Control of alpha subunit of eukaryotic translation initiation factor 2 (eIF2 alpha) phosphorylation by the human papillomavirus type 18 E6 oncoprotein: implications for eIF2 alpha-dependent gene expression and cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Apoptotic pathways: ten minutes to dead

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

The Bcl2 family: regulators of the cellular life-or-death switch

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Heterologous dimerization domains functionally substitute for the double-stranded RNA binding domains of the kinase PKR.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

IKKalpha controls p52/RelB at the skp2 gene promoter to regulate G1- to S-phase progression.

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Cell damage-induced conformational changes of the pro-apoptotic protein Bak in vivo precede the onset of apoptosis

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Bax in murine thymus is a soluble monomeric protein that displays differential detergent-induced conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Stress granules: sites of mRNA triage that regulate mRNA stability and translatability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2alpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Coping with stress: eIF2 kinases and translational control

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

Gene expression during ER stress-induced apoptosis in neurons: induction of the BH3-only protein Bbc3/PUMA and activation of the mitochondrial apoptosis pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M702673200

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

21 January 2018

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https://api.crossref.org/works/10.1074%2FJBC.M702673200

21 January 2018

Identifiers

DOI

10.1074/JBC.M702673200

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3 August 2017

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