DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells (Q34278532)

1 August 2017

title

DNA damage response and MCL-1 destruction initiate apoptosis in adenovirus-infected cells (English)

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1 August 2017

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Eileen White

4

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author name string

Andrea Cuconati

series ordinal

1

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1 August 2017

Chandreyee Mukherjee

series ordinal

2

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1 August 2017

Denise Perez

series ordinal

3

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1 August 2017

publication date

21 November 2003

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1 August 2017

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1 August 2017

volume

17

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1 August 2017

issue

23

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1 August 2017

page(s)

2922-2932

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H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

1 August 2017

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6 July 2018

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6 July 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

6 July 2018

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6 July 2018

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Bak and Bax function to limit adenovirus replication through apoptosis induction

6 July 2018

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6 July 2018

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6 July 2018

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Bax and Bak independently promote cytochrome C release from mitochondria

6 July 2018

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6 July 2018

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6 July 2018

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6 July 2018

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BCL-2, BCL-X(L) sequester BH3 domain-only molecules preventing BAX- and BAK-mediated mitochondrial apoptosis

6 July 2018

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6 July 2018

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E1B 19K blocks Bax oligomerization and tumor necrosis factor alpha-mediated apoptosis

6 July 2018

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BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak

6 July 2018

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6 July 2018

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Pro-apoptotic cascade activates BID, which oligomerizes BAK or BAX into pores that result in the release of cytochrome c.

6 July 2018

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6 July 2018

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MCL-1S, a splicing variant of the antiapoptotic BCL-2 family member MCL-1, encodes a proapoptotic protein possessing only the BH3 domain

6 July 2018

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Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139

6 July 2018

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Btf, a novel death-promoting transcriptional repressor that interacts with Bcl-2-related proteins

6 July 2018

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Adenovirus E1A expression enhances the sensitivity of an ovarian cancer cell line to multiple cytotoxic agents through an apoptotic mechanism

6 July 2018

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E1B 19K inhibits Fas-mediated apoptosis through FADD-dependent sequestration of FLICE.

6 July 2018

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DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

6 July 2018

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Inhibition of nuclear factor-kappaB activity is involved in E1A-mediated sensitization of radiation-induced apoptosis

6 July 2018

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Regulation of p53 levels by the E1B 55-kilodalton protein and E4orf6 in adenovirus-infected cells.

6 July 2018

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p300 binding by E1A cosegregates with p53 induction but is dispensable for apoptosis.

6 July 2018

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Expression of the Epstein Barr virus transforming protein LMP1 causes a rapid and transient stimulation of the Bcl-2 homologue Mcl-1 levels in B-cell lines.

6 July 2018

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The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein

6 July 2018

1 reference

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Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=289151

Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=289151

Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=289151

Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=289151

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=289151

MCL1, a gene expressed in programmed myeloid cell differentiation, has sequence similarity to BCL2

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=289151

Deletion of the gene encoding the adenovirus 5 early region 1b 21,000-molecular-weight polypeptide leads to degradation of viral and host cell DNA

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=289151

Mutations in the gene encoding the adenovirus early region 1B 19,000-molecular-weight tumor antigen cause the degradation of chromosomal DNA.

6 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=289151

An adenovirus type 5 early gene function regulates expression of other early viral genes

6 July 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=289151

The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability.

6 July 2018

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Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors

28 October 2018

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12 December 2020

Mcl-1, a member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells

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12 December 2020

Carcinoma cell lines become sensitive to DNA-damaging agents by the expression of the adenovirus E1A gene

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12 December 2020

The large E1B protein together with the E4orf6 protein target p53 for active degradation in adenovirus infected cells

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12 December 2020

E1A overcomes the apoptosis block in BCR-ABL+ leukemia cells and renders cells susceptible to induction of apoptosis by chemotherapeutic agents

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12 December 2020

TNF-alpha signals apoptosis through a bid-dependent conformational change in Bax that is inhibited by E1B 19K

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12 December 2020

Identifiers

DOI

10.1101/GAD.1156903

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1 August 2017

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1 August 2017

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