The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis (Q34656357)

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English	The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis	scientific article

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7 January 2020

The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivation. RFC as a double edged sword in folate homeostasis (English)

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7 January 2020

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Yehuda G Assaraf

3

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Ilan Ifergan

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Gerrit Jansen

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22 May 2008

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7 January 2020

Journal of Biological Chemistry

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283

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7 January 2020

20687-20695

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7 January 2020

The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption

1 reference

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Molecular basis of antifolate resistance

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Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption

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The role of multidrug resistance efflux transporters in antifolate resistance and folate homeostasis.

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The kidney in vitamin B12 and folate homeostasis: characterization of receptors for tubular uptake of vitamins and carrier proteins

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From methotrexate to pemetrexed and beyond. A review of the pharmacodynamic and clinical properties of antifolates

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Role of folate receptor genes in reproduction and related cancers

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The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.

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Cytoplasmic confinement of breast cancer resistance protein (BCRP/ABCG2) as a novel mechanism of adaptation to short-term folate deprivation.

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Prevalence of multiple micronutrient deficiencies amongst pregnant women in a rural area of Haryana

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Impaired CREB-1 phosphorylation in antifolate-resistant cell lines with down-regulation of the reduced folate carrier gene

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Characterization of a gemcitabine-resistant murine leukemic cell line: reversion of in vitro resistance by a mononucleotide prodrug.

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Distribution, functionality and gene regulation of folate receptor isoforms: implications in targeted therapy

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7 July 2018

Folate and DNA methylation: a mechanistic link between folate deficiency and colorectal cancer?

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7 July 2018

Folate deprivation results in the loss of breast cancer resistance protein (BCRP/ABCG2) expression. A role for BCRP in cellular folate homeostasis

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7 July 2018

Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1).

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7 July 2018

Update on cobalamin, folate, and homocysteine

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21 January 2018

Membrane transport of folates

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7 July 2018

Alterations in the expression of transcription factors and the reduced folate carrier as a novel mechanism of antifolate resistance in human leukemia cells.

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7 July 2018

Loss of multidrug resistance protein 1 expression and folate efflux activity results in a highly concentrative folate transport in human leukemia cells

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7 July 2018

Resistance to multiple novel antifolates is mediated via defective drug transport resulting from clustered mutations in the reduced folate carrier gene in human leukaemia cell lines

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7 July 2018

Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system.

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7 July 2018

Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.

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7 July 2018

Methylation-dependent silencing of the reduced folate carrier gene in inherently methotrexate-resistant human breast cancer cells

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Effects of overexpression of gamma-Glutamyl hydrolase on methotrexate metabolism and resistance

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7 July 2018

Identification of two putative novel folate receptor genes in humans and mouse

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7 July 2018

Human cytosolic and mitochondrial folylpolyglutamate synthetase are electrophoretically distinct. Expression in antifolate-sensitive and -resistant human cell lines

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7 July 2018

Folate and vitamin B12

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7 July 2018

Increased activity of a novel low pH folate transporter associated with lipophilic antifolate resistance in chinese hamster ovary cells

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7 July 2018

pH dependence of methotrexate transport by the reduced folate carrier and the folate receptor in L1210 leukemia cells. Further evidence for a third route mediated at low pH.

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Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity

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7 July 2018

Inherited disorders of cobalamin metabolism

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7 July 2018

Obligate genetic expression in tumor cells of a fetal membrane property mediating "folate" transport: biological significance and implications for improved therapy of human cancer

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7 July 2018

Molecular cloning and characterization of the human folate-binding protein cDNA from placenta and malignant tissue culture (KB) cells

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Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism

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7 July 2018

Homologous membrane folate binding proteins in human placenta: cloning and sequence of a cDNA

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7 July 2018

The complete amino acid sequence of a human folate binding protein from KB cells determined from the cDNA

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7 July 2018

Complementary DNA for the folate binding protein correctly predicts anchoring to the membrane by glycosyl-phosphatidylinositol

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7 July 2018

Methotrexate transport in variant human CCRF-CEM leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates

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Secretion of gamma-glutamyl hydrolase in vitro.

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The biological chemistry of folate receptors

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7 July 2018

Severe folate restriction results in depletion of and alteration in the composition of the intracellular folate pool, moderate sensitization to methotrexate and trimetrexate, upregulation of endogenous DHFR activity, and overexpression of metallothi

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Folate depletion increases sensitivity of solid tumor cell lines to 5-fluorouracil and antifolates.

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21 January 2018

Increased expression and characterization of two distinct folate binding proteins in murine erythroleukemia cells

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21 January 2018

Rescue of embryonic lethality in reduced folate carrier-deficient mice by maternal folic acid supplementation reveals early neonatal failure of hematopoietic organs

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21 January 2018

Reduced folate carrier transports thiamine monophosphate: an alternative route for thiamine delivery into mammalian cells

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21 January 2018

Computer modelling of antifolate inhibition of folate metabolism using hybrid functional petri nets

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21 January 2018

Expression of multidrug resistance-related transporters in human breast carcinoma

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21 January 2018

Epidemiological survey of vitamin deficiencies in older Thai adults: implications for national policy planning

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Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age.

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26 October 2018

Nutritional epigenetics: impact of folate deficiency on DNA methylation and colon cancer susceptibility.

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26 October 2018

The reduced folate carrier gene is a novel selectable marker for recombinant protein overexpression.

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26 October 2018

Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter

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26 October 2018

Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport.

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26 October 2018

Role of folylpolyglutamate synthetase and folylpolyglutamate hydrolase in methotrexate accumulation and polyglutamylation in childhood leukemia.

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26 October 2018

Regulation of folate and one-carbon metabolism in mammalian cells. III. Role of mitochondrial folylpoly-gamma-glutamate synthetase.

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26 October 2018

Regulation of folate and one-carbon metabolism in mammalian cells. I. Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity.

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26 October 2018

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12 December 2020

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The characteristics of the membrane transport of amethopterin and the naturally occurring folates

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12 December 2020

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Differential stereospecificities and affinities of folate receptor isoforms for folate compounds and antifolates

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12 December 2020

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Characterization of folate receptor from normal and neoplastic murine tissue: influence of dietary folate on folate receptor expression

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Identifiers

10.1074/JBC.M802812200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18499665%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18499665%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18499665%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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