Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway (Q34658504)

3 August 2017

title

Increased iron loading induces Bmp6 expression in the non-parenchymal cells of the liver independent of the BMP-signaling pathway (English)

1 reference

3 August 2017

Caroline A Enns

1

1 reference

3 August 2017

Riffat Ahmed

2

1 reference

3 August 2017

Jiaohong Wang

3

1 reference

3 August 2017

Akiko Ueno

4

1 reference

3 August 2017

Christal Worthen

5

1 reference

3 August 2017

Hidekazu Tsukamoto

6

1 reference

3 August 2017

An-Sheng Zhang

7

1 reference

3 August 2017

language of work or name

English

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publication date

2 April 2013

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3 August 2017

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3 August 2017

volume

8

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3 August 2017

issue

4

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3 August 2017

page(s)

e60534

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Creative Commons Attribution 4.0 International

3 August 2017

copyright license

start time

2 April 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice

7 July 2018

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Serum and liver iron differently regulate the bone morphogenetic protein 6 (BMP6)-SMAD signaling pathway in mice

7 July 2018

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Deficiency of liver sinusoidal scavenger receptors stabilin-1 and -2 in mice causes glomerulofibrotic nephropathy via impaired hepatic clearance of noxious blood factors.

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Suppression of hepatic hepcidin expression in response to acute iron deprivation is associated with an increase of matriptase-2 protein

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7 July 2018

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Hepcidin and disorders of iron metabolism

7 July 2018

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Two to tango: regulation of Mammalian iron metabolism

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Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis

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7 July 2018

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Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression

7 July 2018

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Lack of the bone morphogenetic protein BMP6 induces massive iron overload

7 July 2018

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Hepatic macrophage iron aggravates experimental alcoholic steatohepatitis

7 July 2018

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Iron regulates phosphorylation of Smad1/5/8 and gene expression of Bmp6, Smad7, Id1, and Atoh8 in the mouse liver

7 July 2018

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Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

7 July 2018

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Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance

7 July 2018

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Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6

7 July 2018

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7 July 2018

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7 July 2018

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Role of Hepatic Stellate Cells in the Early Phase of Liver Regeneration in Rat: Formation of Tight Adhesion to Parenchymal Cells

7 July 2018

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7 July 2018

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7 July 2018

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Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

7 July 2018

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7 July 2018

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Natural history of juvenile haemochromatosis

7 July 2018

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A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload

7 July 2018

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7 July 2018

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7 July 2018

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Bone morphogenetic protein-6 is expressed in nonparenchymal liver cells and upregulated by transforming growth factor-beta 1

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3615098

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

7 July 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0060534

Localization of iron metabolism–related mRNAs in rat liver indicate that HFE is expressed predominantly in hepatocytes

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0060534

Stimulated erythropoiesis with secondary iron loading leads to a decrease in hepcidin despite an increase in bone morphogenetic protein 6 expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0060534

Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway.

21 January 2018

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A simple technique for measuring storage iron concentrations in formalinised liver samples

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23565256

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0060534

1 reference

3 August 2017

0 references

1 reference

3 August 2017

1 reference