The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis. (Q34662610)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25115793%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

title

The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis (English)

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12 March 2020

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1

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12 March 2020

Lin-Hung Wei

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12 March 2020

Yung-Ming Jeng

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Michael Hsiao

10

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Min-Liang Kuo

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12 March 2020

Men-Luh Yen

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author name string

Ming-Yang Wang

2

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12 March 2020

Min-Wei Chen

3

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12 March 2020

Chi-Kuan Chen

5

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Ching-Huai Ko

6

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12 March 2020

Pi-Lin Sung

8

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12 March 2020

Yi-Hua Jan

9

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12 March 2020

publication date

12 August 2014

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12 March 2020

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12 March 2020

volume

13

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12 March 2020

page(s)

189

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The methyltransferase G9a regulates HoxA9-dependent transcription in AML.

12 March 2020

cites work

1 reference

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BIX-01294 induces autophagy-associated cell death via EHMT2/G9a dysfunction and intracellular reactive oxygen species production

7 July 2018

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The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation

7 July 2018

1 reference

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KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling.

7 July 2018

1 reference

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Role of EZH2 in Epithelial Ovarian Cancer: From Biological Insights to Therapeutic Target

7 July 2018

1 reference

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Selumetinib in women with recurrent low-grade serous carcinoma of the ovary or peritoneum: an open-label, single-arm, phase 2 study

7 July 2018

1 reference

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G9a, a multipotent regulator of gene expression

7 July 2018

1 reference

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G9a functions as a molecular scaffold for assembly of transcriptional coactivators on a subset of glucocorticoid receptor target genes.

7 July 2018

1 reference

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Vav3-rac1 signaling regulates prostate cancer metastasis with elevated Vav3 expression correlating with prostate cancer progression and posttreatment recurrence

7 July 2018

1 reference

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G9a interacts with Snail and is critical for Snail-mediated E-cadherin repression in human breast cancer

7 July 2018

1 reference

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Epigenetics in ovarian cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells

7 July 2018

1 reference

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Up-regulation of METCAM/MUC18 promotes motility, invasion, and tumorigenesis of human breast cancer cells

7 July 2018

1 reference

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H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

BRAF mutation is rare in advanced-stage low-grade ovarian serous carcinomas

7 July 2018

1 reference

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Epigenetics of ovarian cancer: from the lab to the clinic

7 July 2018

1 reference

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G9a and Glp methylate lysine 373 in the tumor suppressor p53

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Analysis of RGS2 expression and prognostic significance in stage II and III colorectal cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

A gene signature predictive for outcome in advanced ovarian cancer identifies a survival factor: microfibril-associated glycoprotein 2.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Integrin beta3 down-regulates invasive features of ovarian cancer cells in SKOV3 cell subclones

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Regulator of G-protein signalling expression and function in ovarian cancer cell lines.

7 July 2018

1 reference

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Control of cellular GADD34 levels by the 26S proteasome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Gene expression profiles of luteal phase fallopian tube epithelium from BRCA mutation carriers resemble high-grade serous carcinoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

GADD34 induces p21 expression and cellular senescence

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Primary culture of ovarian surface epithelial cells and ascites-derived ovarian cancer cells from patients

7 July 2018

1 reference

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Mechanisms of transcoelomic metastasis in ovarian cancer.

7 July 2018

1 reference

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Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells

7 July 2018

1 reference

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5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Ovarian cancer metastasis: integrating insights from disparate model organisms

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Novel NG36/G9a gene products encoded within the human and mouse MHC class III regions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Ovarian surface epithelium: biology, endocrinology, and pathology

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Cadherins in cancer: implications for invasion and metastasis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Loss of S100A14 expression is associated with the progression of adenocarcinomas of the small intestine.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Mutation of ERBB2 provides a novel alternative mechanism for the ubiquitous activation of RAS-MAPK in ovarian serous low malignant potential tumors.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

E2Fs mediate a fundamental cell-cycle deregulation in high-grade serous ovarian carcinomas

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

A six-gene signature predicting breast cancer lung metastasis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Alterations of DNA methylation and histone modifications contribute to gene silencing in hepatocellular carcinomas.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Expression analysis of stage III serous ovarian adenocarcinoma distinguishes a sub-group of survivors.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4260797

Characterization of active mitogen-activated protein kinase in ovarian serous carcinomas

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25115793

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Efficient inhibition of intra-peritoneal tumor growth and dissemination of human ovarian carcinoma cells in nude mice by anti-L1-cell adhesion molecule monoclonal antibody treatment

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25115793

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1476-4598-13-189

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25115793%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

12 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25115793%20AND%20SRC:MED&resulttype=core&format=json

12 March 2020

PubMed publication ID

25115793

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25115793%20AND%20SRC:MED&resulttype=core&format=json