Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome. (Q34673469)

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13 March 2020

title

Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome (English)

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13 March 2020

1 reference

4

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13 March 2020

Xiaoyi Huang

6

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13 March 2020

author name string

Meijun Du

1

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13 March 2020

Tiezheng Yuan

2

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13 March 2020

Kala F Schilter

3

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13 March 2020

Alexander Mackinnon

5

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13 March 2020

Michael Tschannen

7

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13 March 2020

Elizabeth Worthey

8

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13 March 2020

Howard Jacob

9

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13 March 2020

Shu Xia

10

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13 March 2020

Jianzhong Gao

11

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13 March 2020

Lori Tillmans

12

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13 March 2020

Yan Lu

13

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13 March 2020

Pengyuan Liu

14

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13 March 2020

Stephen N Thibodeau

15

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13 March 2020

Liang Wang

16

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13 March 2020

publication date

22 August 2014

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13 March 2020

published in

Human Molecular Genetics

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13 March 2020

volume

24

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13 March 2020

issue

1

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13 March 2020

page(s)

154-166

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High-throughput screening of a CRISPR/Cas9 library for functional genomics in human cells

13 March 2020

cites work

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Comprehensive functional annotation of 77 prostate cancer risk loci

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Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.

7 July 2018

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Genome-scale CRISPR-Cas9 knockout screening in human cells

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Lessons from functional analysis of genome-wide association studies

7 July 2018

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Canonical Wnt signaling regulates Nkx3.1 expression and luminal epithelial differentiation during prostate organogenesis.

7 July 2018

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eQTL Mapping Using RNA-seq Data

7 July 2018

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Exploring the three-dimensional organization of genomes: interpreting chromatin interaction data

7 July 2018

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Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array

7 July 2018

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Multiplexed chromosome conformation capture sequencing for rapid genome-scale high-resolution detection of long-range chromatin interactions

7 July 2018

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Integrative eQTL-based analyses reveal the biology of breast cancer risk loci

7 July 2018

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Genome-wide association studies: inherent limitations and future challenges

7 July 2018

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A study based on whole-genome sequencing yields a rare variant at 8q24 associated with prostate cancer

7 July 2018

1 reference

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Gene density, transcription, and insulators contribute to the partition of the Drosophila genome into physical domains

7 July 2018

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An integrated encyclopedia of DNA elements in the human genome

7 July 2018

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Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis

7 July 2018

1 reference

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Spatial partitioning of the regulatory landscape of the X-inactivation centre

7 July 2018

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Topological domains in mammalian genomes identified by analysis of chromatin interactions

7 July 2018

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Three-dimensional folding and functional organization principles of the Drosophila genome

7 July 2018

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HERC2 rs12913832 modulates human pigmentation by attenuating chromatin-loop formation between a long-range enhancer and the OCA2 promoter

7 July 2018

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A decade of 3C technologies: insights into nuclear organization

7 July 2018

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Genome architectures revealed by tethered chromosome conformation capture and population-based modeling

7 July 2018

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Enhancer and promoter interactions-long distance calls

7 July 2018

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Sequence-specific capture of protein-DNA complexes for mass spectrometric protein identification

7 July 2018

1 reference

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Needles in stacks of needles: finding disease-causal variants in a wealth of genomic data

7 July 2018

1 reference

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A functional variant at a prostate cancer predisposition locus at 8q24 is associated with PVT1 expression

7 July 2018

1 reference

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BioGraph: unsupervised biomedical knowledge discovery via automated hypothesis generation

7 July 2018

1 reference

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E2F1 suppresses Wnt/β-catenin activity through transactivation of β-catenin interacting protein ICAT.

7 July 2018

1 reference

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Mapping and analysis of chromatin state dynamics in nine human cell types

7 July 2018

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Genomics tools for unraveling chromosome architecture

7 July 2018

1 reference

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Genomewide association studies and assessment of the risk of disease

7 July 2018

1 reference

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8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC.

7 July 2018

1 reference

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GREAT improves functional interpretation of cis-regulatory regions

7 July 2018

1 reference

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Long-range enhancers on 8q24 regulate c-Myc

7 July 2018

1 reference

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Target-enrichment strategies for next-generation sequencing

7 July 2018

1 reference

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Bioinformatics challenges for genome-wide association studies

7 July 2018

1 reference

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An oestrogen-receptor-α-bound human chromatin interactome

7 July 2018

1 reference

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Comprehensive mapping of long-range interactions reveals folding principles of the human genome

7 July 2018

1 reference

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Functional enhancers at the gene-poor 8q24 cancer-linked locus.

7 July 2018

1 reference

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Chromosome conformation capture (from 3C to 5C) and its ChIP-based modification

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Evaluation of the 8q24 prostate cancer risk locus and MYC expression.

7 July 2018

1 reference

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Long-range chromosomal interactions and gene regulation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Sequence variant on 8q24 confers susceptibility to urinary bladder cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Multiple loci with different cancer specificities within the 8q24 gene desert

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

An evaluation of 3C-based methods to capture DNA interactions

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Quantitative analysis of chromosome conformation capture assays (3C-qPCR).

7 July 2018

1 reference

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Genome-wide association study identifies novel breast cancer susceptibility loci

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Multiple regions within 8q24 independently affect risk for prostate cancer

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Nuclear organization of active and inactive chromatin domains uncovered by chromosome conformation capture-on-chip (4C).

7 July 2018

1 reference

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Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elements

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Chromosomal organization: mingling with the neighbors

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations

7 July 2018

1 reference

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Long-range interactions between three transcriptional enhancers, active Vkappa gene promoters, and a 3' boundary sequence spanning 46 kilobases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Looping and interaction between hypersensitive sites in the active beta-globin locus

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Capturing chromosome conformation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Sensitive detection of chromatin coassociations using enhanced chromosome conformation capture on chip.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Mouse Tcf3 represses canonical Wnt signaling by either competing for β-catenin binding or through occupation of DNA-binding sites

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Multiple loci on 8q24 associated with prostate cancer susceptibility.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Multiple independent genetic variants in the 8q24 region are associated with prostate cancer risk

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

Genome-wide association scan identifies a colorectal cancer susceptibility locus on chromosome 8q24.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4262497

9 December 2018

Identifiers

DOI

10.1093/HMG/DDU426

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25149474%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25149474%20AND%20SRC:MED&resulttype=core&format=json

13 March 2020

PubMed publication ID

25149474

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25149474%20AND%20SRC:MED&resulttype=core&format=json