Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity (Q34684632)

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English	Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity	scientific article

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scholarly article

1 reference

Europe PubMed Central

3 August 2017

Presenilins promote the cellular uptake of copper and zinc and maintain copper chaperone of SOD1-dependent copper/zinc superoxide dismutase activity (English)

1 reference

Europe PubMed Central

3 August 2017

molecular chaperones

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Irene Volitakis

object named as

Irene Volitakis

2

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object named as

Ashley I Bush

9

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author name string

Mark A Greenough

1

1 reference

Europe PubMed Central

3 August 2017

Qiao-Xin Li

3

1 reference

Europe PubMed Central

3 August 2017

Katrina Laughton

4

1 reference

Europe PubMed Central

3 August 2017

Genevieve Evin

5

1 reference

Europe PubMed Central

3 August 2017

Michael Ho

6

1 reference

Europe PubMed Central

3 August 2017

Andrew H Dalziel

7

1 reference

Europe PubMed Central

3 August 2017

James Camakaris

8

1 reference

Europe PubMed Central

3 August 2017

language of work or name

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publication date

14 January 2011

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Europe PubMed Central

3 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

3 August 2017

286

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Europe PubMed Central

3 August 2017

11

1 reference

Europe PubMed Central

3 August 2017

9776-9786

1 reference

Europe PubMed Central

3 August 2017

Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

Deficiency of the copper chaperone for superoxide dismutase increases amyloid-β production

1 reference

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Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations

1 reference

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Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics

1 reference

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gamma-secretases: from cell biology to therapeutic strategies

1 reference

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Human copper homeostasis: a network of interconnected pathways.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

Copper in the brain and Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

Zinc deficiency

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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Mammalian zinc transporters: nutritional and physiologic regulation

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

gamma-Secretase in biology and medicine

1 reference

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SERCA pump activity is physiologically regulated by presenilin and regulates amyloid beta production

1 reference

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Endocytosis is required for synaptic activity-dependent release of amyloid-beta in vivo

1 reference

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Metals in Alzheimer's and Parkinson's diseases

1 reference

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Evidence that the ZNT3 protein controls the total amount of elemental zinc in synaptic vesicles

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

1 reference

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Pathological and physiological functions of presenilins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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The effects of glutaredoxin and copper activation pathways on the disulfide and stability of Cu,Zn superoxide dismutase

1 reference

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7 July 2018

Regulation of tyrosinase trafficking and processing by presenilins: partial loss of function by familial Alzheimer's disease mutation

1 reference

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The neurobiology of zinc in health and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

Transition-state analogue gamma-secretase inhibitors stabilize a 900 kDa presenilin/nicastrin complex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

NMDA receptor activation mediates copper homeostasis in hippocampal neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

Zinc transporters, ZnT5 and ZnT7, are required for the activation of alkaline phosphatases, zinc-requiring enzymes that are glycosylphosphatidylinositol-anchored to the cytoplasmic membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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Advanced transfection with Lipofectamine 2000 reagent: primary neurons, siRNA, and high-throughput applications

1 reference

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7 July 2018

Mechanisms for activating Cu- and Zn-containing superoxide dismutase in the absence of the CCS Cu chaperone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations

1 reference

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Dynamic Traffic through the Recycling Compartment Couples the Metal Transporter Nramp2 (DMT1) with the Transferrin Receptor

1 reference

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Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

1 reference

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A physiologic signaling role for the gamma -secretase-derived intracellular fragment of APP.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

Biochemical characterization of the human copper transporter Ctr1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

1 reference

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Crystal structure of alkaline phosphatase from human placenta at 1.8 A resolution. Implication for a substrate specificity

1 reference

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Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status

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Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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Correction of the copper transport defect of Menkes patient fibroblasts by expression of the Menkes and Wilson ATPases.

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Cloning and characterization of a mammalian proton-coupled metal-ion transporter

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Skeletal and CNS defects in Presenilin-1-deficient mice

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

7 July 2018

The beta A4 amyloid precursor protein binding to copper.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3058959

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Cu(2+) inhibition of glycine-activated currents in rat sacral dorsal commissural neurons

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21 January 2018

A role for synaptic zinc in activity-dependent Abeta oligomer formation and accumulation at excitatory synapses.

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21 January 2018

Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin

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21 January 2018

Gene amplification of the Menkes (MNK; ATP7A) P-type ATPase gene of CHO cells is associated with copper resistance and enhanced copper efflux

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21 January 2018

Gender and genetic background effects on brain metal levels in APP transgenic and normal mice: implications for Alzheimer beta-amyloid pathology.

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21 January 2018

Presenilin 2 expression in neuronal cells: induction during differentiation of embryonic carcinoma cells.

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Capacitative calcium entry induces hippocampal long term potentiation in the absence of presenilin-1.

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21 January 2018

Reduced antioxidant enzyme activity in brains of mice transgenic for human presenilin-1 with single or multiple mutations.

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21 January 2018

Metallochaperone for Cu,Zn-superoxide dismutase (CCS) protein but not mRNA is higher in organs from copper-deficient mice and rats.

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21 January 2018

Identifying genes that interact with Drosophila presenilin and amyloid precursor protein.

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21 January 2018

BACE1 cytoplasmic domain interacts with the copper chaperone for superoxide dismutase-1 and binds copper.

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21 January 2018

Effects of PS1 deficiency on membrane protein trafficking in neurons.

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21 January 2018

Dramatic aggregation of Alzheimer abeta by Cu(II) is induced by conditions representing physiological acidosis.

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21 January 2018

The mechanism of copper uptake mediated by human CTR1: a mutational analysis.

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21 January 2018

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

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Presenilin-mediated modulation of capacitative calcium entry

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1)

1 reference

https://pubmed.ncbi.nlm.nih.gov/21239495

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M110.163964

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

1 reference

Europe PubMed Central

3 August 2017

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