T-cell-receptor gene therapy (Q34718133)

4 August 2017

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title

T-cell-receptor gene therapy (English)

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4 August 2017

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Ton N M Schumacher

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4 August 2017

1 July 2002

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Nature Reviews Immunology

4 August 2017

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4 August 2017

2

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4 August 2017

7

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4 August 2017

512-519

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Immunotherapy for rheumatoid arthritis

4 August 2017

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Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

31 March 2020

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Adoptive immunotherapy prevents prostate cancer in a transgenic animal model

31 March 2020

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Impact of T-cell depletion on outcome of allogeneic bone-marrow transplantation for standard-risk leukaemias

31 March 2020

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Identical-twin bone marrow transplants for leukemia.

31 March 2020

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Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor

31 March 2020

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Use of gene-modified virus-specific T lymphocytes to control Epstein-Barr-virus-related lymphoproliferation

31 March 2020

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Transfer of specificity by murine alpha and beta T-cell receptor genes

31 March 2020

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Transfer of specificity for human immunodeficiency virus type 1 into primary human T lymphocytes by introduction of T-cell receptor genes

31 March 2020

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Functional reconstitution of class II MHC-restricted T cell immunity mediated by retroviral transfer of the alpha beta TCR complex

31 March 2020

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Dual HLA class I and class II restricted recognition of alloreactive T lymphocytes mediated by a single T cell receptor complex

31 March 2020

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Retroviral transduction of a T cell receptor specific for an Epstein-Barr virus-encoded peptide

31 March 2020

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Circumventing tolerance to a human MDM2-derived tumor antigen by TCR gene transfer

31 March 2020

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Immunotherapy through TCR gene transfer

31 March 2020

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De novo methylation and expression of retroviral genomes during mouse embryogenesis.

31 March 2020

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Lack of expression from a retroviral vector after transduction of murine hematopoietic stem cells is associated with methylation in vivo

31 March 2020

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Human beta interferon scaffold attachment region inhibits de novo methylation and confers long-term, copy number-dependent expression to a retroviral vector

31 March 2020

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The cHS4 insulator increases the probability of retroviral expression at random chromosomal integration sites.

31 March 2020

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A chromatin insulator protects retrovirus vectors from chromosomal position effects

31 March 2020

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Cytokine signals are sufficient for HIV-1 infection of resting human T lymphocytes

31 March 2020

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Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease

31 March 2020

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T cell activation determined by T cell receptor number and tunable thresholds.

31 March 2020

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How much TCR does a T cell need?

31 March 2020

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In vitro evolution of a T cell receptor with high affinity for peptide/MHC.

31 March 2020

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Changing T cell specificity by retroviral T cell receptor display

31 March 2020

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Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex

31 March 2020

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CD8(-) T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation.

31 March 2020

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A kinetic window constricts the T cell receptor repertoire in the thymus.

31 March 2020

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Expression of two T cell receptor alpha chains: dual receptor T cells

31 March 2020

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Non-obese diabetic mice hemizygous at the T cell receptor alpha locus are susceptible to diabetes and sialitis.

31 March 2020

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Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus.

31 March 2020

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T cell receptor repertoire for a viral epitope in humans is diversified by tolerance to a background major histocompatibility complex antigen

31 March 2020

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T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients

31 March 2020

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HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemia

31 March 2020

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Nonmyeloablative immunosuppressive regimen prolongs In vivo persistence of gene-modified autologous T cells in a nonhuman primate model

31 March 2020

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Phenotypic analysis of antigen-specific T lymphocytes

31 March 2020

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A Fas-based suicide switch in human T cells for the treatment of graft-versus-host disease

31 March 2020

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Definition of T cell idiotypes using anti-idiotypic antisera produced by immunization with T cell clones

31 March 2020

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Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

31 March 2020

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Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

31 March 2020

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Specific T helper cell requirement for optimal induction of cytotoxic T lymphocytes against major histocompatibility complex class II negative tumors

31 March 2020

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The central role of CD4(+) T cells in the antitumor immune response

31 March 2020

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Viral immune evasion due to persistence of activated T cells without effector function

31 March 2020

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Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL-10-transduced islet-specific Th1 lymphocytes. A gene therapy model for autoimmune diabetes

31 March 2020

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Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis.

31 March 2020

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Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit

31 March 2020

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Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis

31 March 2020

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The activity of immunoregulatory T cells mediating active tolerance is potentiated in nonobese diabetic mice by an IL-4-based retroviral gene therapy

31 March 2020

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Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor

31 March 2020

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Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

31 March 2020

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The role of CCR7 in TH1 and TH2 cell localization and delivery of B cell help in vivo

31 March 2020

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A novel transcription factor, T-bet, directs Th1 lineage commitment

31 March 2020

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Tumor-specific T-bodies: towards clinical application

31 March 2020

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Redirecting mouse CTL against colon carcinoma: superior signaling efficacy of single-chain variable domain chimeras containing TCR-zeta vs Fc epsilon RI-gamma

31 March 2020

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Growth retardation of tumors by adoptive transfer of cytotoxic T lymphocytes reprogrammed by CD44v6-specific scFv:zeta-chimera

31 March 2020

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The protein interactions of the immunoglobulin receptor family tyrosine-based activation motifs present in the T cell receptor zeta subunits and the CD3 gamma, delta and epsilon chains

31 March 2020

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Membrane domains and the immunological synapse: keeping T cells resting and ready.

31 March 2020

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Dynamics of the immunological synapse: finding, establishing and solidifying a connection

31 March 2020

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Structural basis of T cell recognition

31 March 2020

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Ligand-specific oligomerization of T-cell receptor molecules

31 March 2020

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alpha beta T cell receptor ligand-specific oligomerization revisited

31 March 2020

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Receptor proximity, not intermolecular orientation, is critical for triggering T-cell activation

31 March 2020

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From TCR Engagement to T Cell Activation

31 March 2020

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Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition

31 March 2020

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Ligand recognition by alpha beta T cell receptors

31 March 2020

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Escape of human immunodeficiency virus from immune control

31 March 2020

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Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors

31 March 2020

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Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein

31 March 2020

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How tumors escape immune destruction and what we can do about it.

31 March 2020

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Insertional mutagenesis: neoplasia arising from retroviral integration.

31 March 2020

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Gene therapy: trials and tribulations

31 March 2020

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Resident aliens: the Tc1/mariner superfamily of transposable elements

31 March 2020

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Episomal vectors for gene expression in mammalian cells

31 March 2020

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Cytotoxic T-lymphocyte epitope immunodominance in the control of choroid plexus tumors in simian virus 40 large T antigen transgenic mice.

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRI841

1 reference

4 August 2017

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PubMed ID

12094225