Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues. (Q34731577)

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English	Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues.	scientific article

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23 February 2020

Comparative characterization of the lactimidomycin and iso-migrastatin biosynthetic machineries revealing unusual features for acyltransferase-less type I polyketide synthases and providing an opportunity to engineer new analogues (English)

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23 February 2020

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23 February 2020

Jeremy R. Lohman

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Jeremy R Lohman

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23 February 2020

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Jeong-Woo Seo

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23 February 2020

Ming Ma

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23 February 2020

Thomas Kwong

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23 February 2020

Jianhua Ju

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23 February 2020

Si-Kyu Lim

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23 February 2020

Hui Jiang

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23 February 2020

Chunying Yang

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23 February 2020

John Cleveland

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23 February 2020

Emmanuel Zazopoulos

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23 February 2020

Ben Shen

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23 February 2020

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1 December 2014

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23 February 2020

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23 February 2020

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23 February 2020

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23 February 2020

7854-7865

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23 February 2020

Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase

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Vinylogous chain branching catalysed by a dedicated polyketide synthase module

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Biosynthesis of 9-methylstreptimidone involves a new decarboxylative step for polyketide terminal diene formation

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7 July 2018

Post-polyketide synthase steps in iso-migrastatin biosynthesis, featuring tailoring enzymes with broad substrate specificity

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Emergence of potent inhibitors of metastasis in lung cancer via syntheses based on migrastatin.

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Cycloheximide and congeners as inhibitors of eukaryotic protein synthesis from endophytic actinomycetes Streptomyces sps. YIM56132 and YIM56141.

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Multifaceted Modes of Action for the Glutarimide‐Containing Polyketides Revealed

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Biosynthesis of polyketides by trans-AT polyketide synthases

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Migrastatin analogues target fascin to block tumour metastasis

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Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

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7 July 2018

iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase.

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7 July 2018

Lactimidomycin, iso-migrastatin and related glutarimide-containing 12-membered macrolides are extremely potent inhibitors of cell migration.

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Evaluation of new migrastatin and dorrigocin congeners unveils cell migration inhibitors with dramatically improved potency.

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New lactimidomycin congeners shed insight into lactimidomycin biosynthesis in Streptomyces amphibiosporus

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Radical intermediates in the catalytic oxidation of hydrocarbons by bacterial and human cytochrome P450 enzymes

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Biocatalytic conversion of avermectin to 4"-oxo-avermectin: characterization of biocatalytically active bacterial strains and of cytochrome p450 monooxygenase enzymes and their genes.

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Iso-migrastatin congeners from Streptomyces platensis and generation of a glutarimide polyketide library featuring the dorrigocin, lactimidomycin, migrastatin, and NK30424 scaffolds

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Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice

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Polyketide biosynthesis beyond the type I, II and III polyketide synthase paradigms

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PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin

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Migrastatin and a new compound, isomigrastatin, from Streptomyces platensis

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Migrastatin, a New Inhibitor of Tumor Cell Migration from Streptomyces sp. MK929-43F1. Taxonomy, Fermentation, Isolation and Biological Activities.

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10.1021/BI501396V

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23 February 2020

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23 February 2020

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23 February 2020

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