Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF. (Q34732660)

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31 December 2019

title

Lrig1 is an endogenous inhibitor of Ret receptor tyrosine kinase activation, downstream signaling, and biological responses to GDNF (English)

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31 December 2019

4

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31 December 2019

author name string

Fernanda Ledda

1

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31 December 2019

Oliver Bieraugel

2

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31 December 2019

Shahrzad Shirazi Fard

3

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31 December 2019

Gustavo Paratcha

5

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31 December 2019

language of work or name

English

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publication date

1 January 2008

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31 December 2019

published in

Journal of Neuroscience

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31 December 2019

volume

28

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31 December 2019

issue

1

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31 December 2019

page(s)

39-49

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describes a project that uses

31 December 2019

ImageQuant

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11 June 2022

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inferred from PubMed Central ID database lookup

cites work

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GDNF family neurotrophic factor signaling: four masters, one servant?

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GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival

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Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins

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Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts.

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Mammalian sprouty-1 and -2 are membrane-anchored phosphoprotein inhibitors of growth factor signaling in endothelial cells

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Lipid rafts and signal transduction

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Cloning, characterization, and expression of human LIG1.

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Inhibition of Ret oncogene activity by the protein tyrosine phosphatase SHP1.

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The GDNF family: signalling, biological functions and therapeutic value

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Targeted disruption of LIG-1 gene results in psoriasiform epidermal hyperplasia

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Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme

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Target-derived GFRalpha1 as an attractive guidance signal for developing sensory and sympathetic axons via activation of Cdk5.

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AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats

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Negative receptor signalling

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Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.

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Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

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The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands

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Mechanism of inhibition of the Drosophila and mammalian EGF receptors by the transmembrane protein Kekkon 1.

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Characterization and tissue-specific expression of human LRIG2.

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LRIG1 restricts growth factor signaling by enhancing receptor ubiquitylation and degradation

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The leucine-rich repeat protein LRIG1 is a negative regulator of ErbB family receptor tyrosine kinases

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Distinct turnover of alternatively spliced isoforms of the RET kinase receptor mediated by differential recruitment of the Cbl ubiquitin ligase

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Negative regulation of receptor tyrosine kinases: unexpected links to c-Cbl and receptor ubiquitylation

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Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction

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Mitogen-inducible gene 6 is an endogenous inhibitor of HGF/Met-induced cell migration and neurite growth

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AMIGO and friends: an emerging family of brain-enriched, neuronal growth modulating, type I transmembrane proteins with leucine-rich repeats (LRR) and cell adhesion molecule motifs

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Glial cell line-derived neurotrophic factor-dependent recruitment of Ret into lipid rafts enhances signaling by partitioning Ret from proteasome-dependent degradation

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12 December 2020

Mig6 is a negative regulator of EGF receptor-mediated skin morphogenesis and tumor formation

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Cell Survival through Trk Neurotrophin Receptors Is Differentially Regulated by Ubiquitination

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The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins

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A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity

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LRIG1 is a novel negative regulator of the Met receptor and opposes Met and Her2 synergy

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Epidermal growth factor signaling mediated by grb2 associated binder1 is required for the spatiotemporally regulated proliferation of olig2-expressing progenitors in the embryonic spinal cord.

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Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase

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GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle

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12 December 2020

Functional receptor for GDNF encoded by the c-ret proto-oncogene

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12 December 2020

GDNF signalling through the Ret receptor tyrosine kinase

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12 December 2020

Characterization of a multicomponent receptor for GDNF.

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12 December 2020

GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF

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12 December 2020

cDNA cloning of a novel membrane glycoprotein that is expressed specifically in glial cells in the mouse brain. LIG-1, a protein with leucine-rich repeats and immunoglobulin-like domains

1 reference

12 December 2020

10.1523/JNEUROSCI.2196-07.2008

Identifiers

DOI

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31 December 2019

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