The GDNF family: signalling, biological functions and therapeutic value (Q28216478)

Nature Reviews Neuroscience

Europe PubMed Central

title

The GDNF family: signalling, biological functions and therapeutic value (English)

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author name string

Matti S Airaksinen

series ordinal

1

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Mart Saarma

series ordinal

2

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language of work or name

English

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publication date

May 2002

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published in

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volume

3

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page(s)

383-94

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issue

5

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cites work

GDNF family neurotrophic factor signaling: four masters, one servant?

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The GDNF family ligands and receptors - implications for neural development

22 April 2017

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Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse

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Regulation of cell survival by secreted proneurotrophins

22 April 2017

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Distinct structural elements in GDNF mediate binding to GFRalpha1 and activation of the GFRalpha1-c-Ret receptor complex

22 April 2017

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Lipid rafts and signal transduction

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Neurotrophin signal transduction in the nervous system

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Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis

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The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease

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GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion

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Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in mice

22 April 2017

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The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives

22 April 2017

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Molecular modeling of the extracellular domain of the RET receptor tyrosine kinase reveals multiple cadherin-like domains and a calcium-binding site

22 April 2017

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Molecular basis of long-term plasticity underlying addiction

22 April 2017

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Emerging themes in structural biology of neurotrophic factors

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Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin

31 March 2020

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The GDNF/RET signaling pathway and human diseases

31 March 2020

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Human glial cell line-derived neurotrophic factor receptor alpha 4 is the receptor for persephin and is predominantly expressed in normal and malignant thyroid medullary cells

31 March 2020

1 reference

Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts.

31 March 2020

1 reference

GDNF triggers a novel ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1.

31 March 2020

1 reference

GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival

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Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival

31 March 2020

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The RET receptor: function in development and dysfunction in congenital malformation

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Cell signaling by receptor tyrosine kinases

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PI-3 kinase and IP3 are both necessary and sufficient to mediate NT3-induced synaptic potentiation

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NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons.

31 March 2020

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Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons in vivo.

31 March 2020

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Neurotrophins as synaptic modulators

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Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase

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Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells

31 March 2020

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Evidence for a ligand-specific signaling through GFRalpha-1, but not GFRalpha-2, in the absence of Ret.

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Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development

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Neurotrophin-3 promotes the cholinergic differentiation of sympathetic neurons

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Regulation of glial cell line-derived neurotrophic factor responsiveness in developing rat sympathetic neurons by retinoic acid and bone morphogenetic protein-2.

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Nitric oxide acts independently of cGMP to modulate capacitative Ca(2+) entry in mouse parotid acini

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Double heterozygosity for a RET substitution interfering with splicing and an EDNRB missense mutation in Hirschsprung disease

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Tackling pain at the source: new ideas about nociceptors

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The glial cell line-derived neurotrophic factor family receptor components are differentially regulated within sensory neurons after nerve injury.

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Depletion of GDNF from primary afferents in adult rat dorsal horn following peripheral axotomy

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Glial cell line-derived neurotrophic factor and developing mammalian motoneurons: regulation of programmed cell death among motoneuron subtypes.

31 March 2020

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Synergistic effects of schwann- and muscle-derived factors on motoneuron survival involve GDNF and cardiotrophin-1 (CT-1).

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GFRalpha 1 is required for development of distinct subpopulations of motoneuron.

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Glial cell line-derived neurotrophic factor administration in postnatal life results in motor unit enlargement and continuous synaptic remodeling at the neuromuscular junction.

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Overexpression of GDNF induces and maintains hyperinnervation of muscle fibers and multiple end-plate formation

31 March 2020

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Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons

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Glial cell line-derived neurotrophic factor is essential for postnatal survival of midbrain dopamine neurons.

31 March 2020

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Inhibition of brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor expression reduces dopaminergic sprouting in the injured striatum.

31 March 2020

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Regulation of cell fate decision of undifferentiated spermatogonia by GDNF.

31 March 2020

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Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus.

31 March 2020

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IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivo

31 March 2020

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Neurotrophins from dorsal root ganglia trigger allodynia after spinal nerve injury in rats.

31 March 2020

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Pericellular Griffonia simplicifolia I isolectin B4-binding ring structures in the dorsal root ganglia following peripheral nerve injury in rats.

31 March 2020

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Potent analgesic effects of GDNF in neuropathic pain states.

31 March 2020

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Functional regeneration of sensory axons into the adult spinal cord.

31 March 2020

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GDNF rescues nonpeptidergic unmyelinated primary afferents in streptozotocin-treated diabetic mice

31 March 2020

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Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex

31 March 2020

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Reduction of ischemic brain injury by topical application of glial cell line-derived neurotrophic factor after permanent middle cerebral artery occlusion in rats

31 March 2020

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Stroke induces widespread changes of gene expression for glial cell line-derived neurotrophic factor family receptors in the adult rat brain

31 March 2020

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Neuroprotection mediated by glial cell line-derived neurotrophic factor: involvement of a reduction of NMDA-induced calcium influx by the mitogen-activated protein kinase pathway.

31 March 2020

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Development and persistence of kindling epilepsy are impaired in mice lacking glial cell line-derived neurotrophic factor family receptor alpha 2.

31 March 2020

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Glial cell line-derived neurotrophic factor (GDNF): a drug candidate for the treatment of Parkinson's disease

31 March 2020

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Clinicopathological findings following intraventricular glial-derived neurotrophic factor treatment in a patient with Parkinson's disease

31 March 2020

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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease

31 March 2020

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Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease.

31 March 2020

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Towards a neuroprotective gene therapy for Parkinson's disease: use of adenovirus, AAV and lentivirus vectors for gene transfer of GDNF to the nigrostriatal system in the rat Parkinson model

31 March 2020

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Sustained delivery of GDNF: towards a treatment for Parkinson's disease

31 March 2020

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Role for GDNF in biochemical and behavioral adaptations to drugs of abuse.

31 March 2020

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Pax3 is required for enteric ganglia formation and functions with Sox10 to modulate expression of c-ret

31 March 2020

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Impaired water maze learning performance without altered dopaminergic function in mice heterozygous for the GDNF mutation

31 March 2020

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Ca(2+) binding protein frequenin mediates GDNF-induced potentiation of Ca(2+) channels and transmitter release

31 March 2020

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GDNF acutely modulates excitability and A-type K(+) channels in midbrain dopaminergic neurons

31 March 2020

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Determinants of ligand binding specificity in the glial cell line-derived neurotrophic factor family receptor alpha S.

31 March 2020

1 reference

Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists

31 March 2020

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Distinct roles for GFRalpha1 and GFRalpha2 signalling in different cranial parasympathetic ganglia in vivo

31 March 2020

1 reference

inferred from DOI database lookup

7 January 2021

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Identifiers

DOI

10.1038/NRN812

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Consolidated OpenCitations Corpus – April 2017

Dimensions Publication ID

131447

1047324296

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131447

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Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference