A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites (Q34753532)

4 August 2017

title

A genetically attenuated malaria vaccine candidate based on P. falciparum b9/slarp gene-deficient sporozoites (English)

1 reference

sporozoite and liver stage asparagine-rich protein

4 August 2017

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10 September 2018

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GeneDB

sporozoite and liver stage asparagine-rich protein

11 September 2018

Plasmodium falciparum

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1 reference

19 December 2018

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19 December 2018

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13

Philip Meuleman

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4 August 2017

6

Geert-Jan van Gemert

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Geert Leroux-Roels

12

Marga van de Vegte-Bolmer

Geert Leroux-Roels

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8

Marga van de Vegte-Bolmer

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Severine Chevalley-Maurel

4 August 2017

7

Severine Chevalley-Maurel

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Jean-François Franetich

10

Jean-Francois Franetich

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Lander Foquet

Lander Foquet

5

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Shahid M Khan

Shahid M Khan

18

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Chris J Janse

Chris J Janse

17

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Robert W Sauerwein

19

Robert W Sauerwein

1 reference

4 August 2017

16

Stephen L Hoffman

1 reference

4 August 2017

2

Ivo H J Ploemen

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4 August 2017

3

Takeshi Annoura

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4 August 2017

1

Ben C L van Schaijk

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4 August 2017

4

Martijn W Vos

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4 August 2017

15

Dominique Mazier

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4 August 2017

author name string

Severine Chevalley-Maurel

7

1 reference

4 August 2017

Mohammed Sajid

9

1 reference

4 August 2017

Jean-Francois Franetich

10

1 reference

4 August 2017

Audrey Lorthiois

11

1 reference

4 August 2017

Cornelius C Hermsen

14

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4 August 2017

language of work or name

English

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publication date

19 November 2014

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4 August 2017

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4 August 2017

volume

3

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A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion

4 August 2017

cites work

1 reference

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Two Plasmodium 6-Cys family-related proteins have distinct and critical roles in liver-stage development

7 July 2018

1 reference

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Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Protection against malaria by intravenous immunization with a nonreplicating sporozoite vaccine

7 July 2018

1 reference

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Liver or blood-stage arrest during malaria sporozoite immunization: the later the better?

7 July 2018

1 reference

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Loss-of-function analyses defines vital and redundant functions of the Plasmodium rhomboid protease family.

7 July 2018

1 reference

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Plasmodium berghei Δp52&p36 parasites develop independent of a parasitophorous vacuole membrane in Huh-7 liver cells

7 July 2018

1 reference

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Controlled human malaria infections by intradermal injection of cryopreserved Plasmodium falciparum sporozoites

7 July 2018

1 reference

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Genetic engineering of attenuated malaria parasites for vaccination

7 July 2018

1 reference

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Whole parasite vaccination approaches for prevention of malaria infection

7 July 2018

1 reference

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A novel 'gene insertion/marker out' (GIMO) method for transgene expression and gene complementation in rodent malaria parasites

7 July 2018

1 reference

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Live attenuated malaria vaccine designed to protect through hepatic CD8⁺ T cell immunity

7 July 2018

1 reference

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Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Disruption of the Plasmodium falciparum liver-stage antigen-1 locus causes a differentiation defect in late liver-stage parasites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Long-term protection against malaria after experimental sporozoite inoculation: an open-label follow-up study

7 July 2018

1 reference

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A research agenda for malaria eradication: vaccines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Removal of heterologous sequences from Plasmodium falciparum mutants using FLPe-recombinase

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Three members of the 6-cys protein family of Plasmodium play a role in gamete fertility

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Development of a metabolically active, non-replicating sporozoite vaccine to prevent Plasmodium falciparum malaria

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Visualisation and quantitative analysis of the rodent malaria liver stage by real time imaging

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Protection against a malaria challenge by sporozoite inoculation

7 July 2018

1 reference

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Preerythrocytic, live-attenuated Plasmodium falciparum vaccine candidates by design

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Conserved protective mechanisms in radiation and genetically attenuated uis3(-) and uis4(-) Plasmodium sporozoites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Type II fatty acid synthesis is essential only for malaria parasite late liver stage development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Gene disruption of Plasmodium falciparum p52 results in attenuation of malaria liver stage development in cultured primary human hepatocytes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

A sporozoite asparagine-rich protein controls initiation of Plasmodium liver stage development

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Targeted deletion of SAP1 abolishes the expression of infectivity factors necessary for successful malaria parasite liver infection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Functional characterization of a redundant Plasmodium TRAP family invasin, TRAP-like protein, by aldolase binding and a genetic complementation test

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Genetically attenuated P36p-deficient Plasmodium berghei sporozoites confer long-lasting and partial cross-species protection.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Plasmodium yoelii sporozoites with simultaneous deletion of P52 and P36 are completely attenuated and confer sterile immunity against infection

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Live and let die: manipulation of host hepatocytes by exoerythrocytic Plasmodium parasites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

High-efficiency transfection and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Biological safety concepts of genetically modified live bacterial vaccines

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Plasmodium falciparum ensures its amino acid supply with multiple acquisition pathways and redundant proteolytic enzyme systems

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

High efficiency transfection of Plasmodium berghei facilitates novel selection procedures

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Genetically attenuated, P36p-deficient malarial sporozoites induce protective immunity and apoptosis of infected liver cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Morphological and biochemical characterization of a human liver in a uPA-SCID mouse chimera

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Plasmodium liver stage developmental arrest by depletion of a protein at the parasite-host interface

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

A Plasmodium berghei reference line that constitutively expresses GFP at a high level throughout the complete life cycle

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Protection of humans against malaria by immunization with radiation-attenuated Plasmodium falciparum sporozoites

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Chloroquine sensitivity of isolates of Plasmodium falciparum adapted to in vitro culture

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Protective Immunity produced by the Injection of X-irradiated Sporozoites of Plasmodium berghei

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Immunization of man against sporozite-induced falciparum malaria

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Malaria sporozoites leave behind trails of circumsporozoite protein during gliding motility

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

Infectivity of cultured Plasmodium falciparum gametocytes to mosquitoes

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

A malaria heat-shock-like determinant expressed on the infected hepatocyte surface is the target of antibody-dependent cell-mediated cytotoxic mechanisms by nonparenchymal liver cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4273440

SAP1 is a critical post-transcriptional regulator of infectivity in malaria parasite sporozoite stages.

7 July 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.03582

Assessing the adequacy of attenuation of genetically modified malaria parasite vaccine candidates

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.03582

Molecular detection and quantification of Plasmodium falciparum-infected human hepatocytes in chimeric immune-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.03582

Role of heat-labile serum factor or host complement in the inhibition of Plasmodium falciparum sporogonic stages in Anopheles stephensi by gametocyte carriers' serological factors

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.03582

Plasmodium liver load following parenteral sporozoite administration in rodents

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.03582

The potential role of vaccines in the elimination of falciparum malaria and the eventual eradication of malaria

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.03582

Cultivation of fertile Plasmodium falciparum gametocytes in semi-automated systems. 1. Static cultures

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.03582

First-in-human evaluation of genetically attenuated Plasmodium falciparum sporozoites administered by bite of Anopheles mosquitoes to adult volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.03582

Complete in vitro maturation of Plasmodium falciparum gametocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.7554%2FELIFE.03582

21 January 2018

Identifiers

DOI

10.7554/ELIFE.03582

1 reference

4 August 2017

1 reference

4 August 2017

1 reference