A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype. (Q34776341)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

title

A novel strategy to increase the proliferative potential of adult human β-cells while maintaining their differentiated phenotype (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Scot J Matkovich

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Thaddeus S. Stappenbeck

6

object named as

Thaddeus S Stappenbeck

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

author name string

Haytham Aly

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Nidhi Rohatgi

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Connie A Marshall

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Tiffani C Grossenheider

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

Michael L McDaniel

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

language of work or name

English

0 references

publication date

12 June 2013

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

volume

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

issue

6

1 reference

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3 March 2020

page(s)

e66131

1 reference

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Creative Commons Attribution 4.0 International

3 March 2020

copyright license

start time

12 June 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

DESeq2

object named as

DESeq

1 reference

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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In vitro proliferation of adult human beta-cells

7 July 2018

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7 July 2018

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Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip¹ via the ERK signal pathway.

7 July 2018

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Insulin-producing cells generated from dedifferentiated human pancreatic beta cells expanded in vitro

7 July 2018

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cMyc is a principal upstream driver of beta-cell proliferation in rat insulinoma cell lines and is an effective mediator of human beta-cell replication.

7 July 2018

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Activation of the GLP-1 receptor signalling pathway: a relevant strategy to repair a deficient beta-cell mass

7 July 2018

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Parathyroid hormone-related protein enhances human ß-cell proliferation and function with associated induction of cyclin-dependent kinase 2 and cyclin E expression

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Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6

7 July 2018

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Elimination of negative feedback control mechanisms along the insulin signaling pathway improves beta-cell function under stress

7 July 2018

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R-spondin-1 is a novel beta-cell growth factor and insulin secretagogue

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Glycogen synthase kinase-3 and mammalian target of rapamycin pathways contribute to DNA synthesis, cell cycle progression, and proliferation in human islets

7 July 2018

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7 July 2018

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Rac1 GTPase and the Rac1 exchange factor Tiam1 associate with Wnt-responsive promoters to enhance beta-catenin/TCF-dependent transcription in colorectal cancer cells

7 July 2018

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7 July 2018

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Beta-cell replication is the primary mechanism subserving the postnatal expansion of beta-cell mass in humans

7 July 2018

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Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells

7 July 2018

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Genetic and pharmacological inhibition of Rho-associated kinase II enhances adipogenesis.

7 July 2018

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A ROCK inhibitor permits survival of dissociated human embryonic stem cells

7 July 2018

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7 July 2018

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7 July 2018

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R-Spondin proteins: a novel link to beta-catenin activation

7 July 2018

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Rho-kinase as a molecular target for insulin resistance and hypertension

7 July 2018

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Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle

7 July 2018

1 reference

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Mitogenic influence of human R-spondin1 on the intestinal epithelium

7 July 2018

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Role of Rho-kinase in regulation of insulin action and glucose homeostasis.

7 July 2018

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Insulin receptor substrate-2 proteasomal degradation mediated by a mammalian target of rapamycin (mTOR)-induced negative feedback down-regulates protein kinase B-mediated signaling pathway in beta-cells

7 July 2018

1 reference

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The Wnt signaling pathway in development and disease

7 July 2018

1 reference

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R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

Gastrin-mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

Stabilization of beta-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes

7 July 2018

1 reference

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SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

7 July 2018

1 reference

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CREB signaling--timing is everything

7 July 2018

1 reference

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Phosphorylation and inactivation of glycogen synthase kinase 3 by protein kinase A

7 July 2018

1 reference

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Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase

7 July 2018

1 reference

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The role of glycogen synthase kinase 3beta in insulin-stimulated glucose metabolism

7 July 2018

1 reference

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Rho as a mediator of G protein-coupled receptor signaling.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

Effectors for the Rho GTPases

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

Rho GTPases and signaling networks

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

beta-catenin is a target for the ubiquitin-proteasome pathway

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

Phosphorylated CREB binds specifically to the nuclear protein CBP

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

Preservation of beta cell function in adult human pancreatic islets for several months in vitro.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3680388

Growth and regeneration of adult beta cells does not involve specialized progenitors.

7 July 2018

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Induction of beta-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066131

Efficacy of Rho-kinase inhibition in promoting cell survival and reducing reactive gliosis in the rodent retina

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066131

A rho-associated protein kinase, ROKalpha, binds insulin receptor substrate-1 and modulates insulin signaling.

21 January 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0066131

Active Rho kinase (ROK-alpha ) associates with insulin receptor substrate-1 and inhibits insulin signaling in vascular smooth muscle cells.

21 January 2018

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Mechanical stimulation of cyclic tensile strain induces reduction of pluripotent related gene expressions via activation of Rho/ROCK and subsequent decreasing of AKT phosphorylation in human induced pluripotent stem cells.

21 January 2018

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Wnt-independent beta-catenin transactivation in tumor development.

21 January 2018

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A secondary phosphorylation of CREB341 at Ser129 is required for the cAMP-mediated control of gene expression. A role for glycogen synthase kinase-3 in the control of gene expression

26 October 2018

1 reference

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Hypoxic regulation of vascular endothelial growth factor through the induction of phosphatidylinositol 3-kinase/Rho/ROCK and c-Myc

9 December 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/23776620

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

cAMP stimulates protein kinase B in a Wortmannin-insensitive manner

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PubMed

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inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1371/JOURNAL.PONE.0066131

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json

3 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23776620%20AND%20SRC:MED&resulttype=core&format=json