Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas (Q46228157)

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scientific article published on 26 November 2008

Language	Label	Description	Also known as
English	Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas	scientific article published on 26 November 2008

Statements

scholarly article

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19034385

Increased STAT-3 and synchronous activation of Raf-1-MEK-1-MAPK, and phosphatidylinositol 3-Kinase-Akt-mTOR pathways in atypical and anaplastic meningiomas (English)

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19034385

author name string

Mahlon D Johnson

1

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19034385

Mary O'Connell

2

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19034385

Fran Vito

3

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19034385

Robert S Bakos

4

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19034385

publication date

26 November 2008

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Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19034385

Journal of Neuro-Oncology

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Europe PubMed Central

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http://europepmc.org/abstract/MED/19034385

92

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http://europepmc.org/abstract/MED/19034385

2

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http://europepmc.org/abstract/MED/19034385

129-136

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http://europepmc.org/abstract/MED/19034385

https://scigraph.springernature.com/pub.10.1007/s11060-008-9746-7

0 references

Targeted drug therapy for meningiomas

1 reference

https://api.crossref.org/works/10.1007%2FS11060-008-9746-7

21 January 2018

Evidence for mitogen-associated protein kinase activation and transduction of mitogenic signals by platelet-derived growth factor in human meningioma cells

1 reference

https://api.crossref.org/works/10.1007%2FS11060-008-9746-7

21 January 2018

Stat proteins and oncogenesis

1 reference

https://api.crossref.org/works/10.1007%2FS11060-008-9746-7

21 January 2018

Molecular characterization of human meningiomas by gene expression profiling using high-density oligonucleotide microarrays

1 reference

https://api.crossref.org/works/10.1007%2FS11060-008-9746-7

21 January 2018

AKT1/PKBalpha kinase is frequently elevated in human cancers and its constitutive activation is required for oncogenic transformation in NIH3T3 cells

1 reference

https://api.crossref.org/works/10.1007%2FS11060-008-9746-7

21 January 2018

mTOR and cancer: insights into a complex relationship

1 reference

https://api.crossref.org/works/10.1007%2FS11060-008-9746-7

21 January 2018

Platelet-Derived Growth Factor-BB and Thrombin Activate Phosphoinositide 3-Kinase and Protein Kinase B: Role in Mediating Airway Smooth Muscle Proliferation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

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Epidermal growth factor receptor expression in 72 meningiomas

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https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

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Evidence for phosphatidylinositol 3-kinase-Akt-p7S6K pathway activation and transduction of mitogenic signals by platelet-derived growth factor in meningioma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

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Concomitant activation of the JAK/STAT, PI3K/AKT, and ERK signaling is involved in leptin-mediated promotion of invasion and migration of hepatocellular carcinoma cells

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https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

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The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

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Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

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Different activation of mitogen-activated protein kinase and Akt signaling is associated with aggressive phenotype of human meningiomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

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Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human meningiomas co-express platelet-derived growth factor (PDGF) and PDGF-receptor genes and their protein products

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Akt/PKB family of protein kinases: a review of small molecule inhibitors and progress towards target validation

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a proline-rich Akt substrate as a 14-3-3 binding partner

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the cytoplasmic and nuclear functions of signal transducers and activators of transcription 3 for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

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PIK3CA is implicated as an oncogene in ovarian cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the epidermal growth factor receptor in human meningioma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitogenic signal transduction pathways in meningiomas: novel targets for meningioma chemotherapy?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PKB/Akt mediates radiosensitization by the signaling inhibitor LY294002 in human malignant gliomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidermal growth factor receptor dependence in human tumors: more than just expression?

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The epidermal growth factor receptor is associated with phospholipase C-gamma 1 in meningiomas

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Detection of activated platelet-derived growth factor receptors in human meningioma.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphatidylinositol 3-kinases in tumor progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A high ratio of insulin-like growth factor II/insulin-like growth factor binding protein 2 messenger RNA as a marker for anaplasia in meningiomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New paradigms in anticancer therapy: targeting multiple signaling pathways with kinase inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PRAS40 deregulates apoptosis in malignant melanoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

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Targeting the ERK signaling pathway in cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Signal transducers and activators of transcription (STATs): Novel targets of chemopreventive and chemotherapeutic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI-3-kinase is an essential anti-apoptotic effector in the proliferative response of primary human epithelial cells to mutant RAS

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Expression of the JAK and STAT superfamilies in human meningiomas.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

mTOR, translation initiation and cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine control of human meningioma proliferation: secretion of platelet-derived growth-factor-like molecules

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrating signals from RTKs to ERK/MAPK.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stat3 as a potential target for cancer immunotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting the AKT protein kinase for cancer chemoprevention

1 reference

https://pubmed.ncbi.nlm.nih.gov/19034385

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/S11060-008-9746-7

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19034385

1 reference

Europe PubMed Central

20 December 2017

http://europepmc.org/abstract/MED/19034385

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