The WNT signalling pathway and diabetes mellitus (Q34807472)

4 August 2017

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title

The WNT signalling pathway and diabetes mellitus (English)

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4 August 2017

T Jin

1

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4 August 2017

12 August 2008

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4 August 2017

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4 August 2017

51

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4 August 2017

1771-1780

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4 August 2017

10

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https://scigraph.springernature.com/pub.10.1007/s00125-008-1084-y

4 August 2017

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cites work

Expression of the type I diabetes-associated gene LRP5 in macrophages, vitamin A system cells, and the Islets of Langerhans suggests multiple potential roles in diabetes

1 reference

https://api.crossref.org/works/10.1007%2FS00125-008-1084-Y

A new low density lipoprotein receptor related protein, LRP5, is expressed in hepatocytes and adrenal cortex, and recognizes apolipoprotein E.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-008-1084-Y

Gastro-intestinal hormones GIP and GLP-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-008-1084-Y

Nutrient availability and growth: regulation of insulin signaling by dFOXO/FOXO1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-008-1084-Y

Insulin-like growth factor-1 regulates endogenous RUNX2 activity in endothelial cells through a phosphatidylinositol 3-kinase/ERK-dependent and Akt-independent signaling pathway

21 January 2018

1 reference

12 December 2020

Haplotype structure, LD blocks, and uneven recombination within the LRP5 gene.

1 reference

12 December 2020

TCF7L2 variation predicts hyperglycemia incidence in a French general population: the data from an epidemiological study on the Insulin Resistance Syndrome (DESIR) study

1 reference

12 December 2020

Skeletal defects in ringelschwanz mutant mice reveal that Lrp6 is required for proper somitogenesis and osteogenesis

1 reference

12 December 2020

GSK-3: tricks of the trade for a multi-tasking kinase

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12 December 2020

Linkage and association mapping of the LRP5 locus on chromosome 11q13 in type 1 diabetes

1 reference

12 December 2020

LRP6 mutation in a family with early coronary disease and metabolic risk factors

1 reference

12 December 2020

Regulation of insulin secretion, glucokinase gene transcription and beta cell proliferation by adipocyte-derived Wnt signalling molecules

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12 December 2020

Beta-catenin is essential for pancreatic acinar but not islet development

1 reference

12 December 2020

Cloning of a novel member of the low-density lipoprotein receptor family

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12 December 2020

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12 December 2020

Insulin resistance causes increased beta-cell mass but defective glucose-stimulated insulin secretion in a murine model of type 2 diabetes

1 reference

12 December 2020

Interaction of FOXO with beta-catenin inhibits beta-catenin/T cell factor activity

1 reference

12 December 2020

Transcriptional activation of the proglucagon gene by lithium and beta-catenin in intestinal endocrine L cells

1 reference

12 December 2020

Expression patterns of Wnts, Frizzleds, sFRPs, and misexpression in transgenic mice suggesting a role for Wnts in pancreas and foregut pattern formation.

1 reference

12 December 2020

Effects of TCF7L2 polymorphisms on obesity in European populations

1 reference

12 December 2020

Replication and identification of novel variants at TCF7L2 associated with type 2 diabetes in Hong Kong Chinese

1 reference

12 December 2020

Association of the gene encoding wingless-type mammary tumor virus integration-site family member 5B (WNT5B) with type 2 diabetes

1 reference

12 December 2020

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1 reference

12 December 2020

Transcription Factor TCF7L2 Genetic Study in the French Population: Expression in Human -Cells and Adipose Tissue and Strong Association With Type 2 Diabetes

1 reference

12 December 2020

FOXO transcription factors at the interface between longevity and tumor suppression

1 reference

12 December 2020

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

1 reference

12 December 2020

A genetic variation of the transcription factor 7-like 2 gene is associated with risk of type 2 diabetes in the Japanese population

1 reference

12 December 2020

The importance of TCF7L2.

1 reference

12 December 2020

The beta-catenin homolog BAR-1 and LET-60 Ras coordinately regulate the Hox gene lin-39 during Caenorhabditis elegans vulval development.

1 reference

12 December 2020

Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes

1 reference

12 December 2020

Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution

1 reference

12 December 2020

Low-density lipoprotein receptor-related protein 5 (LRP5) is essential for normal cholesterol metabolism and glucose-induced insulin secretion

1 reference

12 December 2020

Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms.

1 reference

12 December 2020

Expression of Wnt, Frizzled, sFRP, and DKK genes in adult human pancreas.

1 reference

12 December 2020

A new era in finding Type 2 diabetes genes-the unusual suspects

1 reference

12 December 2020

TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program

1 reference

12 December 2020

Wnt signaling and cancer

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12 December 2020

Attenuated Wnt signaling perturbs pancreatic growth but not pancreatic function

1 reference

12 December 2020

Model organisms as a guide to mammalian aging

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12 December 2020

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12 December 2020

RETRACTED: Transcription factor 7-like 2 regulates beta-cell survival and function in human pancreatic islets

1 reference

12 December 2020

A Phosphatidylinositol 3-kinase-regulated Akt-independent signaling promotes cigarette smoke-induced FRA-1 expression

1 reference

12 December 2020

FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK.

1 reference

12 December 2020

Activation of proglucagon gene transcription by protein kinase-A in a novel mouse enteroendocrine cell line

1 reference

12 December 2020

TCF-4 mediates cell type-specific regulation of proglucagon gene expression by beta-catenin and glycogen synthase kinase-3beta

1 reference

12 December 2020

Wnt signaling in oncogenesis and embryogenesis--a look outside the nucleus

1 reference

12 December 2020

Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells

1 reference

12 December 2020

Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

1 reference

12 December 2020

Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells

1 reference

12 December 2020

Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its complications

1 reference

12 December 2020

A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

1 reference

12 December 2020

FoxO proteins in insulin action and metabolism

1 reference

12 December 2020

Role of the exchange protein directly activated by cyclic adenosine 5'-monophosphate (Epac) pathway in regulating proglucagon gene expression in intestinal endocrine L cells

1 reference

12 December 2020

Regulation of proglucagon transcription by activated transcription factor (ATF) 3 and a novel isoform, ATF3b, through the cAMP-response element/ATF site of the proglucagon gene promoter

1 reference

12 December 2020

The Physiology of Glucagon-like Peptide 1

1 reference

12 December 2020

FoxOs at the crossroads of cellular metabolism, differentiation, and transformation

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12 December 2020

WNTs modulate cell fate and behavior during vertebrate development

1 reference

12 December 2020

Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes

1 reference

12 December 2020

PKA independent and cell type specific activation of the expression of caudal homeobox gene Cdx-2 by cyclic AMP.

1 reference

12 December 2020

Functional interaction between beta-catenin and FOXO in oxidative stress signaling

1 reference

12 December 2020

Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells

1 reference

12 December 2020

Testing the gene or testing a variant? The case of TCF7L2

1 reference

12 December 2020

Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription.

1 reference

12 December 2020

The rat glucagon gene is regulated by a protein kinase A-dependent pathway in pancreatic islet cells

1 reference

12 December 2020

Gene-environment interactions in the pathogenesis of type 2 diabetes and metabolism

1 reference

12 December 2020

Wnt signaling regulates pancreatic beta cell proliferation

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12 December 2020

Polymorphisms of the low-density lipoprotein receptor-related protein 5 (LRP5) gene are associated with obesity phenotypes in a large family-based association study

1 reference

12 December 2020

Replication study for the association of TCF7L2 with susceptibility to type 2 diabetes in a Japanese population

1 reference

12 December 2020

Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes

1 reference

12 December 2020

Characterization of a novel calcium response element in the glucagon gene

1 reference

12 December 2020

Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway

1 reference

12 December 2020

Association Study of the Genetic Polymorphisms of the Transcription Factor 7-Like 2 (TCF7L2) Gene and Type 2 Diabetes in the Chinese Population

1 reference

12 December 2020

TCF7L2 rs7903146 variant does not associate with smallness for gestational age in the French population

1 reference

12 December 2020

Analysis of novel risk loci for type 2 diabetes in a general French population: the D.E.S.I.R. study

1 reference

12 December 2020

Glucagon-like peptide-1 activation of TCF7L2-dependent Wnt signaling enhances pancreatic beta cell proliferation

1 reference

12 December 2020

Evaluation of polymorphisms known to contribute to risk for diabetes in African and African-American populations

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12 December 2020

The biology of incretin hormones

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12 December 2020

Identification of differentially expressed mRNA during pancreas regeneration of rat by mRNA differential display.

1 reference

12 December 2020

Stabilization of beta-catenin impacts pancreas growth.

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12 December 2020

Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element

1 reference

12 December 2020

Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals

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12 December 2020

arrow encodes an LDL-receptor-related protein essential for Wingless signalling

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12 December 2020

Glucagon gene transcription is negatively regulated by insulin in a hamster islet cell line

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12 December 2020

Multiple cis-acting domains mediate basal and adenosine 3',5'-monophosphate-dependent glucagon gene transcription in a mouse neuroendocrine cell line

1 reference

12 December 2020

The emerging role of FOXO transcription factors in pancreatic beta cells.

1 reference

12 December 2020

Proglucagon gene expression is induced by gastrin-releasing peptide in a mouse enteroendocrine cell line

1 reference

12 December 2020

Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids

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12 December 2020

The new type 2 diabetes gene TCF7L2

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12 December 2020

Additive Effects of Obesity and TCF7L2 Variants on Risk for Type 2 Diabetes Among Cardiac Patients

1 reference

12 December 2020

TCF7L2 is reproducibly associated with type 2 diabetes in various ethnic groups: a global meta-analysis

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12 December 2020

Genetics of type 2 diabetes

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12 December 2020

Common single nucleotide polymorphisms in TCF7L2 are reproducibly associated with type 2 diabetes and reduce the insulin response to glucose in nondiabetic individuals

1 reference

12 December 2020

10.1007/S00125-008-1084-Y

Identifiers

DOI

1 reference

PubMed ID

18696049

Dimensions Publication ID

4 August 2017

0 references

1 reference

PubMed ID

18696049